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946 results
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Thermodynamic Dissection of Potency and Selectivity of Cytosolic Hsp90 Inhibitors.
Yoshimura C, Nagatoishi S, Kuroda D, Kodama Y, Uno T, Kitade M, Chong-Takata K, Oshiumi H, Muraoka H, Yamashita S, Kawai Y, Ohkubo S, Tsumoto K. Yoshimura C, et al. Among authors: uno t. J Med Chem. 2021 Mar 11;64(5):2669-2677. doi: 10.1021/acs.jmedchem.0c01715. Epub 2021 Feb 23. J Med Chem. 2021. PMID: 33621080
Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor.
Uno T, Kawai Y, Yamashita S, Oshiumi H, Yoshimura C, Mizutani T, Suzuki T, Chong KT, Shigeno K, Ohkubo M, Kodama Y, Muraoka H, Funabashi K, Takahashi K, Ohkubo S, Kitade M. Uno T, et al. J Med Chem. 2019 Jan 24;62(2):531-551. doi: 10.1021/acs.jmedchem.8b01085. Epub 2018 Dec 21. J Med Chem. 2019. PMID: 30525599
TAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations.
Hasako S, Terasaka M, Abe N, Uno T, Ohsawa H, Hashimoto A, Fujita R, Tanaka K, Okayama T, Wadhwa R, Miyadera K, Aoyagi Y, Yonekura K, Matsuo K. Hasako S, et al. Among authors: uno t. Mol Cancer Ther. 2018 Aug;17(8):1648-1658. doi: 10.1158/1535-7163.MCT-17-1206. Epub 2018 May 10. Mol Cancer Ther. 2018. PMID: 29748209
Transcriptomic analysis reveals high ITGB1 expression as a predictor for poor prognosis of pancreatic cancer.
Iwatate Y, Yokota H, Hoshino I, Ishige F, Kuwayama N, Itami M, Mori Y, Chiba S, Arimitsu H, Yanagibashi H, Takayama W, Uno T, Lin J, Nakamura Y, Tatsumi Y, Shimozato O, Nagase H. Iwatate Y, et al. Among authors: uno t. PLoS One. 2022 Jun 1;17(6):e0268630. doi: 10.1371/journal.pone.0268630. eCollection 2022. PLoS One. 2022. PMID: 35648752 Free PMC article.
946 results