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Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases.
Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK, Gindin M, Hotez PJ, Valenzuela JG, Mohanty B, Swarbrick JD, Wulff H, Iadonato SP, Gutman GA, Beeton C, Pennington MW, Norton RS, Chandy KG. Chhabra S, et al. Among authors: upadhyay sk. FASEB J. 2014 Sep;28(9):3952-64. doi: 10.1096/fj.14-251967. Epub 2014 Jun 2. FASEB J. 2014. PMID: 24891519 Free PMC article.
Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease.
Tarcha EJ, Chi V, Muñoz-Elías EJ, Bailey D, Londono LM, Upadhyay SK, Norton K, Banks A, Tjong I, Nguyen H, Hu X, Ruppert GW, Boley SE, Slauter R, Sams J, Knapp B, Kentala D, Hansen Z, Pennington MW, Beeton C, Chandy KG, Iadonato SP. Tarcha EJ, et al. Among authors: upadhyay sk. J Pharmacol Exp Ther. 2012 Sep;342(3):642-53. doi: 10.1124/jpet.112.191890. Epub 2012 May 25. J Pharmacol Exp Ther. 2012. PMID: 22637724 Free PMC article.
Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance.
Upadhyay SK, Eckel-Mahan KL, Mirbolooki MR, Tjong I, Griffey SM, Schmunk G, Koehne A, Halbout B, Iadonato S, Pedersen B, Borrelli E, Wang PH, Mukherjee J, Sassone-Corsi P, Chandy KG. Upadhyay SK, et al. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2239-48. doi: 10.1073/pnas.1221206110. Epub 2013 May 31. Proc Natl Acad Sci U S A. 2013. PMID: 23729813 Free PMC article.
Potassium channel opening: a subtle two-step.
Upadhyay SK, Nagarajan P, Mathew MK. Upadhyay SK, et al. J Physiol. 2009 Aug 1;587(Pt 15):3851-68. doi: 10.1113/jphysiol.2009.174730. Epub 2009 Jun 15. J Physiol. 2009. PMID: 19528245 Free PMC article.
234 results