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SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.
Rardin MJ, He W, Nishida Y, Newman JC, Carrico C, Danielson SR, Guo A, Gut P, Sahu AK, Li B, Uppala R, Fitch M, Riiff T, Zhu L, Zhou J, Mulhern D, Stevens RD, Ilkayeva OR, Newgard CB, Jacobson MP, Hellerstein M, Goetzman ES, Gibson BW, Verdin E. Rardin MJ, et al. Among authors: uppala r. Cell Metab. 2013 Dec 3;18(6):920-33. doi: 10.1016/j.cmet.2013.11.013. Cell Metab. 2013. PMID: 24315375 Free PMC article.
Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.
Bharathi SS, Zhang Y, Mohsen AW, Uppala R, Balasubramani M, Schreiber E, Uechi G, Beck ME, Rardin MJ, Vockley J, Verdin E, Gibson BW, Hirschey MD, Goetzman ES. Bharathi SS, et al. Among authors: uppala r. J Biol Chem. 2013 Nov 22;288(47):33837-33847. doi: 10.1074/jbc.M113.510354. Epub 2013 Oct 11. J Biol Chem. 2013. PMID: 24121500 Free PMC article.
Nickel inhibits mitochondrial fatty acid oxidation.
Uppala R, McKinney RW, Brant KA, Fabisiak JP, Goetzman ES. Uppala R, et al. Biochem Biophys Res Commun. 2015 Aug 7;463(4):806-10. doi: 10.1016/j.bbrc.2015.06.017. Epub 2015 Jun 5. Biochem Biophys Res Commun. 2015. PMID: 26051273 Free PMC article.
Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant.
Otsubo C, Bharathi S, Uppala R, Ilkayeva OR, Wang D, McHugh K, Zou Y, Wang J, Alcorn JF, Zuo YY, Hirschey MD, Goetzman ES. Otsubo C, et al. Among authors: uppala r. J Biol Chem. 2015 Sep 25;290(39):23897-904. doi: 10.1074/jbc.M115.655837. Epub 2015 Aug 3. J Biol Chem. 2015. PMID: 26240137 Free PMC article.
Aspirin increases mitochondrial fatty acid oxidation.
Uppala R, Dudiak B, Beck ME, Bharathi SS, Zhang Y, Stolz DB, Goetzman ES. Uppala R, et al. Biochem Biophys Res Commun. 2017 Jan 8;482(2):346-351. doi: 10.1016/j.bbrc.2016.11.066. Epub 2016 Nov 14. Biochem Biophys Res Commun. 2017. PMID: 27856258 Free PMC article.
c-Myc programs fatty acid metabolism and dictates acetyl-CoA abundance and fate.
Edmunds LR, Sharma L, Kang A, Lu J, Vockley J, Basu S, Uppala R, Goetzman ES, Beck ME, Scott D, Prochownik EV. Edmunds LR, et al. Among authors: uppala r. J Biol Chem. 2014 Sep 5;289(36):25382-92. doi: 10.1074/jbc.M114.580662. Epub 2014 Jul 22. J Biol Chem. 2014. PMID: 25053415 Free PMC article.
Complex I assembly function and fatty acid oxidation enzyme activity of ACAD9 both contribute to disease severity in ACAD9 deficiency.
Schiff M, Haberberger B, Xia C, Mohsen AW, Goetzman ES, Wang Y, Uppala R, Zhang Y, Karunanidhi A, Prabhu D, Alharbi H, Prochownik EV, Haack T, Häberle J, Munnich A, Rötig A, Taylor RW, Nicholls RD, Kim JJ, Prokisch H, Vockley J. Schiff M, et al. Among authors: uppala r. Hum Mol Genet. 2015 Jun 1;24(11):3238-47. doi: 10.1093/hmg/ddv074. Epub 2015 Feb 26. Hum Mol Genet. 2015. PMID: 25721401 Free PMC article.
60 results