Urban L - Search Results

1

Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure.

Bender A, Scheiber J, Glick M, Davies JW, Azzaoui K, Hamon J, Urban L, Whitebread S, Jenkins JL. Bender A, et al. Among authors: urban l. ChemMedChem. 2007 Jun;2(6):861-73. doi: 10.1002/cmdc.200700026. ChemMedChem. 2007. PMID: 17477341

2

Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development.

Whitebread S, Hamon J, Bojanic D, Urban L. Whitebread S, et al. Among authors: urban l. Drug Discov Today. 2005 Nov 1;10(21):1421-33. doi: 10.1016/S1359-6446(05)03632-9. Drug Discov Today. 2005. PMID: 16243262 Review.

3

High-throughput in vitro profiling assays: lessons learnt from experiences at Novartis.

Faller B, Wang J, Zimmerlin A, Bell L, Hamon J, Whitebread S, Azzaoui K, Bojanic D, Urban L. Faller B, et al. Among authors: urban l. Expert Opin Drug Metab Toxicol. 2006 Dec;2(6):823-33. doi: 10.1517/17425255.2.6.823. Expert Opin Drug Metab Toxicol. 2006. PMID: 17125403 Review.

4

Modeling promiscuity based on in vitro safety pharmacology profiling data.

Azzaoui K, Hamon J, Faller B, Whitebread S, Jacoby E, Bender A, Jenkins JL, Urban L. Azzaoui K, et al. Among authors: urban l. ChemMedChem. 2007 Jun;2(6):874-80. doi: 10.1002/cmdc.200700036. ChemMedChem. 2007. PMID: 17492703

5

Mapping adverse drug reactions in chemical space.

Scheiber J, Jenkins JL, Sukuru SC, Bender A, Mikhailov D, Milik M, Azzaoui K, Whitebread S, Hamon J, Urban L, Glick M, Davies JW. Scheiber J, et al. Among authors: urban l. J Med Chem. 2009 May 14;52(9):3103-7. doi: 10.1021/jm801546k. J Med Chem. 2009. PMID: 19378990

6

Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis.

Scheiber J, Chen B, Milik M, Sukuru SC, Bender A, Mikhailov D, Whitebread S, Hamon J, Azzaoui K, Urban L, Glick M, Davies JW, Jenkins JL. Scheiber J, et al. Among authors: urban l. J Chem Inf Model. 2009 Feb;49(2):308-17. doi: 10.1021/ci800344p. J Chem Inf Model. 2009. PMID: 19434832

7

Phenotypic screening: Fishing for neuroactive compounds.

Jenkins JL, Urban L. Jenkins JL, et al. Among authors: urban l. Nat Chem Biol. 2010 Mar;6(3):172-173. doi: 10.1038/nchembio.320. Nat Chem Biol. 2010. PMID: 20154663 No abstract available.

8

In vitro safety pharmacology profiling: what else beyond hERG?

Hamon J, Whitebread S, Techer-Etienne V, Le Coq H, Azzaoui K, Urban L. Hamon J, et al. Among authors: urban l. Future Med Chem. 2009 Jul;1(4):645-65. doi: 10.4155/fmc.09.51. Future Med Chem. 2009. PMID: 21426031 Review.

9

Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.

Shultz MD, Cao X, Chen CH, Cho YS, Davis NR, Eckman J, Fan J, Fekete A, Firestone B, Flynn J, Green J, Growney JD, Holmqvist M, Hsu M, Jansson D, Jiang L, Kwon P, Liu G, Lombardo F, Lu Q, Majumdar D, Meta C, Perez L, Pu M, Ramsey T, Remiszewski S, Skolnik S, Traebert M, Urban L, Uttamsingh V, Wang P, Whitebread S, Whitehead L, Yan-Neale Y, Yao YM, Zhou L, Atadja P. Shultz MD, et al. Among authors: urban l. J Med Chem. 2011 Jul 14;54(13):4752-72. doi: 10.1021/jm200388e. Epub 2011 Jun 17. J Med Chem. 2011. PMID: 21650221

10

Computational methods for early predictive safety assessment from biological and chemical data.

Nigsch F, Lounkine E, McCarren P, Cornett B, Glick M, Azzaoui K, Urban L, Marc P, Müller A, Hahne F, Heard DJ, Jenkins JL. Nigsch F, et al. Among authors: urban l. Expert Opin Drug Metab Toxicol. 2011 Dec;7(12):1497-511. doi: 10.1517/17425255.2011.632632. Epub 2011 Nov 4. Expert Opin Drug Metab Toxicol. 2011. PMID: 22050465 Review.

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