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Impact of the Natural Compound Urolithin A on Health, Disease, and Aging.
D'Amico D, Andreux PA, Valdés P, Singh A, Rinsch C, Auwerx J. D'Amico D, et al. Trends Mol Med. 2021 Jul;27(7):687-699. doi: 10.1016/j.molmed.2021.04.009. Epub 2021 May 21. Trends Mol Med. 2021. PMID: 34030963 Free article. Review.
Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. ...
Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), compl …
Targeting aging with urolithin A in humans: A systematic review.
Kuerec AH, Lim XK, Khoo AL, Sandalova E, Guan L, Feng L, Maier AB. Kuerec AH, et al. Ageing Res Rev. 2024 Sep;100:102406. doi: 10.1016/j.arr.2024.102406. Epub 2024 Jul 11. Ageing Res Rev. 2024. PMID: 39002645 Free article.
Urolithin A (UA) is a gut metabolite derived from ellagic acid. This systematic review assesses the potential geroprotective effect of UA in humans. ...
Urolithin A (UA) is a gut metabolite derived from ellagic acid. This systematic review assesses the potential geroprotective e …
Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions.
Hou Y, Chu X, Park JH, Zhu Q, Hussain M, Li Z, Madsen HB, Yang B, Wei Y, Wang Y, Fang EF, Croteau DL, Bohr VA. Hou Y, et al. Alzheimers Dement. 2024 Jun;20(6):4212-4233. doi: 10.1002/alz.13847. Epub 2024 May 16. Alzheimers Dement. 2024. PMID: 38753870 Free PMC article.
BACKGROUND: Compromised autophagy, including impaired mitophagy and lysosomal function, plays pivotal roles in Alzheimer's disease (AD). Urolithin A (UA) is a gut microbial metabolite of ellagic acid that stimulates mitophagy. ...CONCLUSIONS: Our study highlights th …
BACKGROUND: Compromised autophagy, including impaired mitophagy and lysosomal function, plays pivotal roles in Alzheimer's disease (AD). …
Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults.
Singh A, D'Amico D, Andreux PA, Fouassier AM, Blanco-Bose W, Evans M, Aebischer P, Auwerx J, Rinsch C. Singh A, et al. Cell Rep Med. 2022 May 17;3(5):100633. doi: 10.1016/j.xcrm.2022.100633. Cell Rep Med. 2022. PMID: 35584623 Free PMC article. Clinical Trial.
The data show significant improvements in muscle strength ( 12%) with intake of Urolithin A. We observe clinically meaningful improvements with Urolithin A on aerobic endurance (peak oxygen oxygen consumption [VO(2)]) and physical performance (6 min wa …
The data show significant improvements in muscle strength ( 12%) with intake of Urolithin A. We observe clinically meaningful …
Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents.
Ryu D, Mouchiroud L, Andreux PA, Katsyuba E, Moullan N, Nicolet-Dit-Félix AA, Williams EG, Jha P, Lo Sasso G, Huzard D, Aebischer P, Sandi C, Rinsch C, Auwerx J. Ryu D, et al. Nat Med. 2016 Aug;22(8):879-88. doi: 10.1038/nm.4132. Epub 2016 Jul 11. Nat Med. 2016. PMID: 27400265
The biological effects of urolithins remain poorly characterized, despite wide-spread human exposure via the dietary consumption of their metabolic precursors, the ellagitannins, which are found in the pomegranate fruit, as well as in nuts and berries. We identified urolithin …
The biological effects of urolithins remain poorly characterized, despite wide-spread human exposure via the dietary consumption of their me …
The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans.
Andreux PA, Blanco-Bose W, Ryu D, Burdet F, Ibberson M, Aebischer P, Auwerx J, Singh A, Rinsch C. Andreux PA, et al. Nat Metab. 2019 Jun;1(6):595-603. doi: 10.1038/s42255-019-0073-4. Epub 2019 Jun 14. Nat Metab. 2019. PMID: 32694802
Urolithin A (UA) is a natural dietary, microflora-derived metabolite shown to stimulate mitophagy and improve muscle health in old animals and in preclinical models of aging(1). ...
Urolithin A (UA) is a natural dietary, microflora-derived metabolite shown to stimulate mitophagy and improve muscle health in …
Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis.
D'Amico D, Olmer M, Fouassier AM, Valdés P, Andreux PA, Rinsch C, Lotz M. D'Amico D, et al. Aging Cell. 2022 Aug;21(8):e13662. doi: 10.1111/acel.13662. Epub 2022 Jul 1. Aging Cell. 2022. PMID: 35778837 Free PMC article.
Here, we showed that Urolithin A improved mitophagy and mitochondrial respiration in primary chondrocytes from joints of both healthy donors and OA patients. Furthermore, Urolithin A reduced disease progression in a mouse model of OA, decreasing cartil …
Here, we showed that Urolithin A improved mitophagy and mitochondrial respiration in primary chondrocytes from joints of both …
Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis.
Lee HJ, Jung YH, Choi GE, Kim JS, Chae CW, Lim JR, Kim SY, Yoon JH, Cho JH, Lee SJ, Han HJ. Lee HJ, et al. Cell Death Differ. 2021 Jan;28(1):184-202. doi: 10.1038/s41418-020-0593-1. Epub 2020 Jul 23. Cell Death Differ. 2021. PMID: 32704090 Free PMC article.
Urolithin A injections in a streptozotocin (STZ)-induced diabetic mouse model alleviated APP and BACE1 expressions, Tau phosphorylation, Abeta deposition, and cognitive impairment. In addition, high glucose stimulated MAM formation and transglutaminase type 2 (TGM2) …
Urolithin A injections in a streptozotocin (STZ)-induced diabetic mouse model alleviated APP and BACE1 expressions, Tau phosph …
Ellagic acid and intestinal microflora metabolite urolithin A: A review on its sources, metabolic distribution, health benefits, and biotransformation.
Zhang M, Cui S, Mao B, Zhang Q, Zhao J, Zhang H, Tang X, Chen W. Zhang M, et al. Crit Rev Food Sci Nutr. 2023;63(24):6900-6922. doi: 10.1080/10408398.2022.2036693. Epub 2022 Feb 10. Crit Rev Food Sci Nutr. 2023. PMID: 35142569 Review.
Therefore, application of "single bacterium", "single bacterium + enzyme", and "microflora" can achieve biotransformation of urolithin A. In this review, the source and metabolic pathway of ellagic tannins, and the mechanisms of the biological function of a metaboli …
Therefore, application of "single bacterium", "single bacterium + enzyme", and "microflora" can achieve biotransformation of urolithin …
Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration.
Jiménez-Loygorri JI, Viedma-Poyatos Á, Gómez-Sintes R, Boya P. Jiménez-Loygorri JI, et al. Mol Neurodegener. 2024 Jun 18;19(1):49. doi: 10.1186/s13024-024-00739-3. Mol Neurodegener. 2024. PMID: 38890703 Free PMC article.
Together with its post-mitotic status and constant photooxidative damage from incoming light, the retina requires a tightly-regulated housekeeping system that involves autophagy. The natural polyphenol Urolithin A (UA) has shown neuroprotective benefits in several m …
Together with its post-mitotic status and constant photooxidative damage from incoming light, the retina requires a tightly-regulated housek …
686 results