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Model-free drug-likeness from fragments.
Ursu O, Oprea TI. Ursu O, et al. J Chem Inf Model. 2010 Aug 23;50(8):1387-94. doi: 10.1021/ci100202p. J Chem Inf Model. 2010. PMID: 20726597
DrugCentral: online drug compendium.
Ursu O, Holmes J, Knockel J, Bologa CG, Yang JJ, Mathias SL, Nelson SJ, Oprea TI. Ursu O, et al. Nucleic Acids Res. 2017 Jan 4;45(D1):D932-D939. doi: 10.1093/nar/gkw993. Epub 2016 Oct 26. Nucleic Acids Res. 2017. PMID: 27789690 Free PMC article.
BDDCS, the Rule of 5 and drugability.
Benet LZ, Hosey CM, Ursu O, Oprea TI. Benet LZ, et al. Among authors: ursu o. Adv Drug Deliv Rev. 2016 Jun 1;101:89-98. doi: 10.1016/j.addr.2016.05.007. Epub 2016 May 13. Adv Drug Deliv Rev. 2016. PMID: 27182629 Free PMC article. Review.
A crowdsourcing evaluation of the NIH chemical probes.
Oprea TI, Bologa CG, Boyer S, Curpan RF, Glen RC, Hopkins AL, Lipinski CA, Marshall GR, Martin YC, Ostopovici-Halip L, Rishton G, Ursu O, Vaz RJ, Waller C, Waldmann H, Sklar LA. Oprea TI, et al. Among authors: ursu o. Nat Chem Biol. 2009 Jul;5(7):441-7. doi: 10.1038/nchembio0709-441. Nat Chem Biol. 2009. PMID: 19536101 Free PMC article.
Drug target ontology to classify and integrate drug discovery data.
Lin Y, Mehta S, Küçük-McGinty H, Turner JP, Vidovic D, Forlin M, Koleti A, Nguyen DT, Jensen LJ, Guha R, Mathias SL, Ursu O, Stathias V, Duan J, Nabizadeh N, Chung C, Mader C, Visser U, Yang JJ, Bologa CG, Oprea TI, Schürer SC. Lin Y, et al. Among authors: ursu o. J Biomed Semantics. 2017 Nov 9;8(1):50. doi: 10.1186/s13326-017-0161-x. J Biomed Semantics. 2017. PMID: 29122012 Free PMC article.
Drug Repurposing from an Academic Perspective.
Oprea TI, Bauman JE, Bologa CG, Buranda T, Chigaev A, Edwards BS, Jarvik JW, Gresham HD, Haynes MK, Hjelle B, Hromas R, Hudson L, Mackenzie DA, Muller CY, Reed JC, Simons PC, Smagley Y, Strouse J, Surviladze Z, Thompson T, Ursu O, Waller A, Wandinger-Ness A, Winter SS, Wu Y, Young SM, Larson RS, Willman C, Sklar LA. Oprea TI, et al. Among authors: ursu o. Drug Discov Today Ther Strateg. 2011 Winter;8(3-4):61-69. doi: 10.1016/j.ddstr.2011.10.002. Drug Discov Today Ther Strateg. 2011. PMID: 22368688 Free PMC article.
The CARLSBAD database: a confederated database of chemical bioactivities.
Mathias SL, Hines-Kay J, Yang JJ, Zahoransky-Kohalmi G, Bologa CG, Ursu O, Oprea TI. Mathias SL, et al. Among authors: ursu o. Database (Oxford). 2013 Jun 21;2013:bat044. doi: 10.1093/database/bat044. Print 2013. Database (Oxford). 2013. PMID: 23794735 Free PMC article.
Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry.
Chen J, Young SM, Allen C, Seeber A, Péli-Gulli MP, Panchaud N, Waller A, Ursu O, Yao T, Golden JE, Strouse JJ, Carter MB, Kang H, Bologa CG, Foutz TD, Edwards BS, Peterson BR, Aubé J, Werner-Washburne M, Loewith RJ, De Virgilio C, Sklar LA. Chen J, et al. Among authors: ursu o. ACS Chem Biol. 2012 Apr 20;7(4):715-22. doi: 10.1021/cb200452r. Epub 2012 Feb 1. ACS Chem Biol. 2012. PMID: 22260433 Free PMC article.
73 results