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24 results

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Page 1
Targeting of phosphorylated tau at threonine 181 by a Qβ virus-like particle vaccine is safe, highly immunogenic, and reduces disease severity in mice and rhesus macaques.
Maphis NM, Hulse J, Peabody J, Dadras S, Whelpley MJ, Kandath M, Wilson C, Hobson S, Thompson J, Poolsup S, Beckman D, Ott SP, Watanabe JW, Usachenko JL, Van Rompay KK, Morrison J, Selwyn R, Rosenberg G, Knoefel J, Chackerian B, Bhaskar K. Maphis NM, et al. Among authors: usachenko jl. Alzheimers Dement. 2025 Mar;21(3):e70101. doi: 10.1002/alz.70101. Alzheimers Dement. 2025. PMID: 40145301 Free PMC article.
FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques.
Zikos J, Webb GM, Wu HL, Reed JS, Watanabe J, Usachenko JL, Shaqra AM, Schiffer CA, Van Rompay KKA, Sacha JB, Magnani DM. Zikos J, et al. Among authors: usachenko jl. MAbs. 2024 Jan-Dec;16(1):2406788. doi: 10.1080/19420862.2024.2406788. Epub 2024 Sep 26. MAbs. 2024. PMID: 39324549 Free PMC article.
Dam-Infant Rhesus Macaque Pairs to Dissect Age-Dependent Responses to SARS-CoV-2 Infection.
Langel SN, Garrido C, Phan C, Travieso T, Kirshner H, DeMarco T, Ma ZM, Reader JR, Olstad KJ, Sammak RL, Shaan Lakshmanappa Y, Roh JW, Watanabe J, Usachenko J, Immareddy R, Pollard R, Iyer SS, Permar S, Miller LA, Van Rompay KKA, Blasi M. Langel SN, et al. Among authors: usachenko j. Immunohorizons. 2022 Dec 1;6(12):851-863. doi: 10.4049/immunohorizons.2200075. Immunohorizons. 2022. PMID: 36547390 Free PMC article.
A Virus-like particle-based bivalent PCSK9 vaccine lowers LDL-cholesterol levels in Non-Human Primates.
Fowler A, Van Rompay KKA, Sampson M, Leo J, Watanabe JK, Usachenko JL, Immareddy R, Lovato DM, Schiller JT, Remaley AT, Chackerian B. Fowler A, et al. Among authors: usachenko jl. bioRxiv [Preprint]. 2023 May 15:2023.05.15.540560. doi: 10.1101/2023.05.15.540560. bioRxiv. 2023. Update in: NPJ Vaccines. 2023 Sep 28;8(1):142. doi: 10.1038/s41541-023-00743-6. PMID: 37292981 Free PMC article. Updated. Preprint.
Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation.
Verma A, Hawes CE, Lakshmanappa YS, Roh JW, Schmidt BA, Dutra J, Louie W, Liu H, Ma ZM, Watanabe JK, Usachenko JL, Immareddy R, Sammak RL, Pollard R, Reader JR, Olstad KJ, Coffey LL, Kozlowski PA, Hartigan-O'Connor DJ, Nussenzweig M, Van Rompay KKA, Morrison JH, Iyer SS. Verma A, et al. Among authors: usachenko jl. Cell Rep. 2021 Nov 2;37(5):109942. doi: 10.1016/j.celrep.2021.109942. Epub 2021 Oct 19. Cell Rep. 2021. PMID: 34706272 Free PMC article.
Infant rhesus macaques immunized against SARS-CoV-2 are protected against heterologous virus challenge 1 year later.
Milligan EC, Olstad K, Williams CA, Mallory M, Cano P, Cross KA, Munt JE, Garrido C, Lindesmith L, Watanabe J, Usachenko JL, Hopkins L, Immareddy R, Shaan Lakshmanappa Y, Elizaldi SR, Roh JW, Sammak RL, Pollard RE, Yee JL, Herbek S, Scobey T, Miehlke D, Fouda G, Ferrari G, Gao H, Shen X, Kozlowski PA, Montefiori D, Hudgens MG, Edwards DK, Carfi A, Corbett KS, Graham BS, Fox CB, Tomai M, Iyer SS, Baric R, Reader R, Dittmer DP, Van Rompay KKA, Permar SR, De Paris K. Milligan EC, et al. Among authors: usachenko jl. Sci Transl Med. 2023 Mar;15(685):eadd6383. doi: 10.1126/scitranslmed.add6383. Epub 2023 Mar 1. Sci Transl Med. 2023. PMID: 36454813 Free PMC article.
SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques.
Shaan Lakshmanappa Y, Elizaldi SR, Roh JW, Schmidt BA, Carroll TD, Weaver KD, Smith JC, Verma A, Deere JD, Dutra J, Stone M, Franz S, Sammak RL, Olstad KJ, Rachel Reader J, Ma ZM, Nguyen NK, Watanabe J, Usachenko J, Immareddy R, Yee JL, Weiskopf D, Sette A, Hartigan-O'Connor D, McSorley SJ, Morrison JH, Tran NK, Simmons G, Busch MP, Kozlowski PA, Van Rompay KKA, Miller CJ, Iyer SS. Shaan Lakshmanappa Y, et al. Among authors: usachenko j. Nat Commun. 2021 Jan 22;12(1):541. doi: 10.1038/s41467-020-20642-x. Nat Commun. 2021. PMID: 33483492 Free PMC article.
SARS-CoV-2 Infection of Rhesus Macaques Treated Early with Human COVID-19 Convalescent Plasma.
Deere JD, Carroll TD, Dutra J, Fritts L, Sammak RL, Yee JL, Olstad KJ, Reader JR, Kistler A, Kamm J, Di Germanio C, Shaan Lakshmanappa Y, Elizaldi SR, Roh JW, Simmons G, Watanabe J, Pollard RE, Usachenko J, Immareddy R, Schmidt BA, O'Connor SL, DeRisi J, Busch MP, Iyer SS, Van Rompay KKA, Hartigan-O'Connor DJ, Miller CJ. Deere JD, et al. Among authors: usachenko j. Microbiol Spectr. 2021 Dec 22;9(3):e0139721. doi: 10.1128/Spectrum.01397-21. Epub 2021 Nov 24. Microbiol Spectr. 2021. PMID: 34817208 Free PMC article.
24 results