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Use of pharmacogenetic data to guide individualized opioid prescribing after surgery.
Rocco R, Thiels CA, Ubl DS, Moyer AM, Habermann EB, Cassivi SD. Rocco R, et al. Surgery. 2019 Oct;166(4):476-482. doi: 10.1016/j.surg.2019.04.033. Epub 2019 Jul 15. Surgery. 2019. PMID: 31320226 Free PMC article.
RESULTS: Of the 2,486 patients with prospective opioid utilization data, 21 had pharmacogenetic data available and were included in the analysis. ...CONCLUSION: This study outlines a possible correlation between genetically controlled metabolism and …
RESULTS: Of the 2,486 patients with prospective opioid utilization data, 21 had pharmacogenetic data available a …
Implementing a pragmatic clinical trial to tailor opioids for acute pain on behalf of the IGNITE ADOPT PGx investigators.
Cavallari LH, Cicali E, Wiisanen K, Fillingim RB, Chakraborty H, Myers RA, Blake KV, Asiyanbola B, Baye JF, Bronson WH, Cook KJ, Elwood EN, Gray CF, Gong Y, Hines L, Kannry J, Kucher N, Lynch S, Nguyen KA, Obeng AO, Pratt VM, Prieto HA, Ramos M, Sadeghpour A, Singh R, Rosenman M, Starostik P, Thomas CD, Tillman E, Dexter PR, Horowitz CR, Orlando LA, Peterson JF, Skaar TC, Van Driest SL, Volpi S, Voora D, Parvataneni HK, Johnson JA; IGNITE Pragmatic Trials Network. Cavallari LH, et al. Clin Transl Sci. 2022 Oct;15(10):2479-2492. doi: 10.1111/cts.13376. Epub 2022 Aug 4. Clin Transl Sci. 2022. PMID: 35899435 Free PMC article. Clinical Trial.
Opioid prescribing for postoperative pain management is challenging because of inter-patient variability in opioid response and concern about opioid addiction. ...Secondary end points include prescription pain medication misuse scores and opi …
Opioid prescribing for postoperative pain management is challenging because of inter-patient variability in opioid …