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Using systems approaches to address challenges for clinical implementation of pharmacogenomics.
Karnes JH, Van Driest S, Bowton EA, Weeke PE, Mosley JD, Peterson JF, Denny JC, Roden DM. Karnes JH, et al. Wiley Interdiscip Rev Syst Biol Med. 2014 Mar-Apr;6(2):125-35. doi: 10.1002/wsbm.1255. Epub 2013 Dec 6. Wiley Interdiscip Rev Syst Biol Med. 2014. PMID: 24319008 Free PMC article. Review.
Given the increasing complexities of drug responses and their variability, a systems approach may be enabling for discovery of new biology in this area. Further, systems approaches may be useful in addressing challenges in moving these data to …
Given the increasing complexities of drug responses and their variability, a systems approach may be enabling for discovery of …
Pharmacogenomics of Drug Hypersensitivity: Technology and Translation.
Kuruvilla R, Scott K, Pirmohamed SM. Kuruvilla R, et al. Immunol Allergy Clin North Am. 2022 May;42(2):335-355. doi: 10.1016/j.iac.2022.01.006. Epub 2022 Mar 31. Immunol Allergy Clin North Am. 2022. PMID: 35469622 Review.
Predisposition seems to be mediated by genetic factors, particularly within the HLA system. Apart from HLA-B57:01 testing, which is routine to prevent abacavir hypersensitivity, uptake of HLA testing into clinical practice has been slow and challenging. As ge …
Predisposition seems to be mediated by genetic factors, particularly within the HLA system. Apart from HLA-B57:01 testing, which is r …
Implementing Precision Medicine: The Ethical Challenges.
Korngiebel DM, Thummel KE, Burke W. Korngiebel DM, et al. Trends Pharmacol Sci. 2017 Jan;38(1):8-14. doi: 10.1016/j.tips.2016.11.007. Epub 2016 Dec 7. Trends Pharmacol Sci. 2017. PMID: 27939182 Free PMC article. Review.
Pharmacogenomics and cancer genetics represent two promising areas for this approach. ...Similarly, tests to identify people with an inherited cancer risk can guide prevention. For both, a few tests have entered clinical practice and more are under developmen …
Pharmacogenomics and cancer genetics represent two promising areas for this approach. ...Similarly, tests to identify people w …
Improving drug safety: From adverse drug reaction knowledge discovery to clinical implementation.
Tan Y, Hu Y, Liu X, Yin Z, Chen XW, Liu M. Tan Y, et al. Methods. 2016 Nov 1;110:14-25. doi: 10.1016/j.ymeth.2016.07.023. Epub 2016 Jul 30. Methods. 2016. PMID: 27485605 Review.
With the same goal of improving drug safety, this article summarizes and links the research efforts in the multiple disciplines into a single framework from comprehensive understanding of the interactions between drugs and biological system and the identification of geneti …
With the same goal of improving drug safety, this article summarizes and links the research efforts in the multiple disciplines into a singl …
Perspectives of Pediatric Providers Regarding Clinical Use of Pharmacogenetics.
Avello K, Bell M, Stein Q, Bares V, Landsverk M, Salyakina D, McCafferty-Fernandez J, Kingsmore S, Bedrick A, Bhojwani D, Hoyme HE. Avello K, et al. S D Med. 2021 Jul;74(7):294-301. S D Med. 2021. PMID: 34449988
Research has shown that children are not just small adults and there are different challenges for pediatric providers in regards to ordering and interpreting PGx tests. ...Additionally, participants identified specific barriers towards the utilization of PGx testing, as we …
Research has shown that children are not just small adults and there are different challenges for pediatric providers in regards to o …
Implementation of Pharmacogenomics and Artificial Intelligence Tools for Chronic Disease Management in Primary Care Setting.
Silva P, Jacobs D, Kriak J, Abu-Baker A, Udeani G, Neal G, Ramos K. Silva P, et al. J Pers Med. 2021 May 21;11(6):443. doi: 10.3390/jpm11060443. J Pers Med. 2021. PMID: 34063850 Free PMC article.
The utility of the approach was validated in a virtual patient case showing detection of significant drug-gene and drug-drug interactions of clinical significance. ...Our integrated informatic and bioanalytic platform can provide facile clinical decision supp …
The utility of the approach was validated in a virtual patient case showing detection of significant drug-gene and drug-drug interact …
The IGNITE network: a model for genomic medicine implementation and research.
Weitzel KW, Alexander M, Bernhardt BA, Calman N, Carey DJ, Cavallari LH, Field JR, Hauser D, Junkins HA, Levin PA, Levy K, Madden EB, Manolio TA, Odgis J, Orlando LA, Pyeritz R, Wu RR, Shuldiner AR, Bottinger EP, Denny JC, Dexter PR, Flockhart DA, Horowitz CR, Johnson JA, Kimmel SE, Levy MA, Pollin TI, Ginsburg GS; IGNITE Network. Weitzel KW, et al. BMC Med Genomics. 2016 Jan 5;9:1. doi: 10.1186/s12920-015-0162-5. BMC Med Genomics. 2016. PMID: 26729011 Free PMC article.
BACKGROUND: Patients, clinicians, researchers and payers are seeking to understand the value of using genomic information (as reflected by genotyping, sequencing, family history or other data) to inform clinical decision-making. However, challenges exist to widespre …
BACKGROUND: Patients, clinicians, researchers and payers are seeking to understand the value of using genomic information (as reflected by g …
Lessons Learned When Introducing Pharmacogenomic Panel Testing into Clinical Practice.
Rosenman MB, Decker B, Levy KD, Holmes AM, Pratt VM, Eadon MT. Rosenman MB, et al. Value Health. 2017 Jan;20(1):54-59. doi: 10.1016/j.jval.2016.08.727. Epub 2016 Oct 21. Value Health. 2017. PMID: 28212969 Free PMC article.
CHALLENGES: We placed the clinical pharmacogenomics implementation challenges into six categories: patient education and engagement in care decision making; clinician education and changes in standards of care; integration of techn …
CHALLENGES: We placed the clinical pharmacogenomics implementation challenges into six categories: patien …
Challenges and strategies for implementing genomic services in diverse settings: experiences from the Implementing GeNomics In pracTicE (IGNITE) network.
Sperber NR, Carpenter JS, Cavallari LH, J Damschroder L, Cooper-DeHoff RM, Denny JC, Ginsburg GS, Guan Y, Horowitz CR, Levy KD, Levy MA, Madden EB, Matheny ME, Pollin TI, Pratt VM, Rosenman M, Voils CI, W Weitzel K, Wilke RA, Ryanne Wu R, Orlando LA. Sperber NR, et al. BMC Med Genomics. 2017 May 22;10(1):35. doi: 10.1186/s12920-017-0273-2. BMC Med Genomics. 2017. PMID: 28532511 Free PMC article.
METHODS: We used a multiple-case study approach with each project considered as a case and qualitative methods to elicit and describe themes related to implementation challenges and strategies. ...Strategies were linked to challenges based on expert re …
METHODS: We used a multiple-case study approach with each project considered as a case and qualitative methods to elicit and describe …
[Network analysis by systemic text excavation of the concept of personalized psychiatry and precision].
Gauld C, Micoulaud-Franchi JA. Gauld C, et al. Encephale. 2021 Aug;47(4):341-347. doi: 10.1016/j.encep.2020.08.008. Epub 2020 Nov 12. Encephale. 2021. PMID: 33190818 French.
OBJECTIVES: The current challenges of psychiatric nosology and semiology are part of an interdisciplinary and integrative framework. ...This framework could be based on a naturalizing but non-reducing formalism, aware of the societal challenges of the sciences and t …
OBJECTIVES: The current challenges of psychiatric nosology and semiology are part of an interdisciplinary and integrative framework. …