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Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide.
Uto Y, Ogata T, Harada J, Kiyotsuka Y, Ueno Y, Miyazawa Y, Kurata H, Deguchi T, Watanabe N, Takagi T, Wakimoto S, Okuyama R, Abe M, Kurikawa N, Kawamura S, Yamato M, Osumi J. Uto Y, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4151-8. doi: 10.1016/j.bmcl.2009.05.119. Epub 2009 Jun 2. Bioorg Med Chem Lett. 2009. PMID: 19540759
Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation.
Uto Y, Ogata T, Kiyotsuka Y, Miyazawa Y, Ueno Y, Kurata H, Deguchi T, Yamada M, Watanabe N, Takagi T, Wakimoto S, Okuyama R, Konishi M, Kurikawa N, Kono K, Osumi J. Uto Y, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4159-66. doi: 10.1016/j.bmcl.2009.05.123. Epub 2009 Jun 6. Bioorg Med Chem Lett. 2009. PMID: 19541482
Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats.
Uto Y, Ogata T, Kiyotsuka Y, Ueno Y, Miyazawa Y, Kurata H, Deguchi T, Watanabe N, Konishi M, Okuyama R, Kurikawa N, Takagi T, Wakimoto S, Ohsumi J. Uto Y, et al. Bioorg Med Chem Lett. 2010 Jan 1;20(1):341-5. doi: 10.1016/j.bmcl.2009.10.101. Epub 2009 Oct 29. Bioorg Med Chem Lett. 2010. PMID: 19926281
Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4'-piperidine].
Uto Y, Kiyotsuka Y, Ueno Y, Miyazawa Y, Kurata H, Ogata T, Deguchi T, Yamada M, Watanabe N, Konishi M, Kurikawa N, Takagi T, Wakimoto S, Kono K, Ohsumi J. Uto Y, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):746-54. doi: 10.1016/j.bmcl.2009.11.043. Epub 2009 Nov 14. Bioorg Med Chem Lett. 2010. PMID: 20006498
Synthesis and evaluation of novel stearoyl-CoA desaturase 1 inhibitors: 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4'-piperidine] analogs.
Uto Y, Ueno Y, Kiyotsuka Y, Miyazawa Y, Kurata H, Ogata T, Yamada M, Deguchi T, Konishi M, Takagi T, Wakimoto S, Ohsumi J. Uto Y, et al. Eur J Med Chem. 2010 Nov;45(11):4788-96. doi: 10.1016/j.ejmech.2010.07.044. Epub 2010 Aug 4. Eur J Med Chem. 2010. PMID: 20801551
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