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Page 1
Covalent inhibition of pro-apoptotic BAX.
McHenry MW, Shi P, Camara CM, Cohen DT, Rettenmaier TJ, Adhikary U, Gygi MA, Yang K, Gygi SP, Wales TE, Engen JR, Wells JA, Walensky LD. McHenry MW, et al. Among authors: adhikary u. Nat Chem Biol. 2024 Aug;20(8):1022-1032. doi: 10.1038/s41589-023-01537-6. Epub 2024 Jan 17. Nat Chem Biol. 2024. PMID: 38233584 Free PMC article.
A triple-action PROTAC for wild-type p53 cancer therapy.
Bird GH, Adhikary U, Schmidt MJ, Godes M, Tesar B, Camara CM, Paulo JA, Vidlak JF, DeAngelo TM, Marquez M, Gokhale P, Li R, Ho Sui SJ, Cameron MD, Gygi SP, Walensky LD. Bird GH, et al. Among authors: adhikary u. Cell Rep Med. 2025 Dec 16;6(12):102467. doi: 10.1016/j.xcrm.2025.102467. Epub 2025 Nov 26. Cell Rep Med. 2025. PMID: 41308642 Free PMC article.
MCL-1 is a master regulator of cancer dependency on fatty acid oxidation.
Prew MS, Adhikary U, Choi DW, Portero EP, Paulo JA, Gowda P, Budhraja A, Opferman JT, Gygi SP, Danial NN, Walensky LD. Prew MS, et al. Among authors: adhikary u. Cell Rep. 2022 Oct 4;41(1):111445. doi: 10.1016/j.celrep.2022.111445. Cell Rep. 2022. PMID: 36198266 Free PMC article.
Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer.
Cathcart AM, Bird GH, Wales TE, Herce HD, Harvey EP, Hauseman ZJ, Newman CE, Adhikary U, Prew MS, Oo T, Lee S, Engen JR, Walensky LD. Cathcart AM, et al. Among authors: adhikary u. Nat Chem Biol. 2020 Nov;16(11):1218-1226. doi: 10.1038/s41589-020-0625-7. Epub 2020 Aug 17. Nat Chem Biol. 2020. PMID: 32807965 Free PMC article.
12 results