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17 results
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Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function.
Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Uysal KT, et al. Nature. 1997 Oct 9;389(6651):610-4. doi: 10.1038/39335. Nature. 1997. PMID: 9335502
Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes.
Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS. Maeda K, et al. Among authors: uysal kt. Cell Metab. 2005 Feb;1(2):107-19. doi: 10.1016/j.cmet.2004.12.008. Cell Metab. 2005. PMID: 16054052 Free article.
Interaction of tumor necrosis factor-alpha- and thiazolidinedione-regulated pathways in obesity.
Wellen KE, Uysal KT, Wiesbrock S, Yang Q, Chen H, Hotamisligil GS. Wellen KE, et al. Among authors: uysal kt. Endocrinology. 2004 May;145(5):2214-20. doi: 10.1210/en.2003-1580. Epub 2004 Feb 5. Endocrinology. 2004. PMID: 14764635
Role of the fatty acid binding protein mal1 in obesity and insulin resistance.
Maeda K, Uysal KT, Makowski L, Görgün CZ, Atsumi G, Parker RA, Brüning J, Hertzel AV, Bernlohr DA, Hotamisligil GS. Maeda K, et al. Among authors: uysal kt. Diabetes. 2003 Feb;52(2):300-7. doi: 10.2337/diabetes.52.2.300. Diabetes. 2003. PMID: 12540600 Free PMC article.
A central role for JNK in obesity and insulin resistance.
Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS. Hirosumi J, et al. Among authors: uysal kt. Nature. 2002 Nov 21;420(6913):333-6. doi: 10.1038/nature01137. Nature. 2002. PMID: 12447443
Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity.
Xu H, Uysal KT, Becherer JD, Arner P, Hotamisligil GS. Xu H, et al. Among authors: uysal kt. Diabetes. 2002 Jun;51(6):1876-83. doi: 10.2337/diabetes.51.6.1876. Diabetes. 2002. PMID: 12031976 Free article.
Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis.
Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MF. Makowski L, et al. Among authors: uysal kt. Nat Med. 2001 Jun;7(6):699-705. doi: 10.1038/89076. Nat Med. 2001. PMID: 11385507 Free PMC article.
Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance.
Xu H, Hirosumi J, Uysal KT, Guler AD, Hotamisligil GS. Xu H, et al. Among authors: uysal kt. Endocrinology. 2002 Apr;143(4):1502-11. doi: 10.1210/endo.143.4.8715. Endocrinology. 2002. PMID: 11897709
Tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity.
Nisoli E, Briscini L, Giordano A, Tonello C, Wiesbrock SM, Uysal KT, Cinti S, Carruba MO, Hotamisligil GS. Nisoli E, et al. Among authors: uysal kt. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8033-8. doi: 10.1073/pnas.97.14.8033. Proc Natl Acad Sci U S A. 2000. PMID: 10884431 Free PMC article.
Upregulation of uncoupling protein 2 mRNA in genetic obesity: lack of an essential role for leptin, hyperphagia, increased tissue lipid content, and TNF-alpha.
Memon RA, Hotamisligil GS, Wiesbrock SM, Uysal KT, Faggioni R, Moser AH, Feingold KR, Grunfeld C. Memon RA, et al. Among authors: uysal kt. Biochim Biophys Acta. 2000 Feb 24;1484(1):41-50. doi: 10.1016/s1388-1981(99)00195-x. Biochim Biophys Acta. 2000. PMID: 10685029
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