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A safe and highly efficient tumor-targeted type I interferon immunotherapy depends on the tumor microenvironment.
Cauwels A, Van Lint S, Garcin G, Bultinck J, Paul F, Gerlo S, Van der Heyden J, Bordat Y, Catteeuw D, De Cauwer L, Rogge E, Verhee A, Uzé G, Tavernier J. Cauwels A, et al. Among authors: Uze G. Oncoimmunology. 2017 Nov 27;7(3):e1398876. doi: 10.1080/2162402X.2017.1398876. eCollection 2018. Oncoimmunology. 2017. PMID: 29399401 Free PMC article.
Delivering Type I Interferon to Dendritic Cells Empowers Tumor Eradication and Immune Combination Treatments.
Cauwels A, Van Lint S, Paul F, Garcin G, De Koker S, Van Parys A, Wueest T, Gerlo S, Van der Heyden J, Bordat Y, Catteeuw D, Rogge E, Verhee A, Vandekerckhove B, Kley N, Uzé G, Tavernier J. Cauwels A, et al. Among authors: Uze G. Cancer Res. 2018 Jan 15;78(2):463-474. doi: 10.1158/0008-5472.CAN-17-1980. Epub 2017 Nov 29. Cancer Res. 2018. PMID: 29187401 Free article.
High efficiency cell-specific targeting of cytokine activity.
Garcin G, Paul F, Staufenbiel M, Bordat Y, Van der Heyden J, Wilmes S, Cartron G, Apparailly F, De Koker S, Piehler J, Tavernier J, Uzé G. Garcin G, et al. Among authors: Uze G. Nat Commun. 2014;5:3016. doi: 10.1038/ncomms4016. Nat Commun. 2014. PMID: 24398568
The receptor of the type I interferon family.
Uzé G, Schreiber G, Piehler J, Pellegrini S. Uzé G, et al. Curr Top Microbiol Immunol. 2007;316:71-95. doi: 10.1007/978-3-540-71329-6_5. Curr Top Microbiol Immunol. 2007. PMID: 17969444 Review.
Interferon-alpha and -beta differentially regulate osteoclastogenesis: role of differential induction of chemokine CXCL11 expression.
Coelho LF, Magno de Freitas Almeida G, Mennechet FJ, Blangy A, Uzé G. Coelho LF, et al. Among authors: Uze G. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11917-22. doi: 10.1073/pnas.0502188102. Epub 2005 Aug 4. Proc Natl Acad Sci U S A. 2005. PMID: 16081539 Free PMC article.
IFNα signaling through PKC-θ is essential for antitumor NK cell function.
Comet NR, Aguiló JI, Rathoré MG, Catalán E, Garaude J, Uzé G, Naval J, Pardo J, Villalba M, Anel A. Comet NR, et al. Among authors: Uze G. Oncoimmunology. 2014 Nov 14;3(8):e948705. doi: 10.4161/21624011.2014.948705. eCollection 2014. Oncoimmunology. 2014. PMID: 25960930 Free PMC article.
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