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An inventory of the human ABC proteins.
Klein I, Sarkadi B, Váradi A. Klein I, et al. Biochim Biophys Acta. 1999 Dec 6;1461(2):237-62. doi: 10.1016/s0005-2736(99)00161-3. Biochim Biophys Acta. 1999. PMID: 10581359 Review.
Currently 30 human ABC proteins are represented by full sequences in various databases, and this paper provides a brief overview of these proteins. ...Mutations of many human ABC proteins are known to be causative in inherited diseases, and a short description of th …
Currently 30 human ABC proteins are represented by full sequences in various databases, and this paper provides a brief overview of t …
ABCC6-mediated ATP secretion by the liver is the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation-brief report.
Jansen RS, Duijst S, Mahakena S, Sommer D, Szeri F, Váradi A, Plomp A, Bergen AA, Oude Elferink RP, Borst P, van de Wetering K. Jansen RS, et al. Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1985-9. doi: 10.1161/ATVBAHA.114.304017. Epub 2014 Jun 26. Arterioscler Thromb Vasc Biol. 2014. PMID: 24969777 Free PMC article.
Patients with PXE have a strongly reduced plasma PPi level, explaining their mineralization disorder. Our results indicate that systemic PPi is relatively stable and that PXE, generalized arterial calcification of infancy, and other ectopic mineralization disorders could b …
Patients with PXE have a strongly reduced plasma PPi level, explaining their mineralization disorder. Our results indicate that syste …
Pyrophosphate Supplementation Prevents Chronic and Acute Calcification in ABCC6-Deficient Mice.
Pomozi V, Brampton C, van de Wetering K, Zoll J, Calio B, Pham K, Owens JB, Marh J, Moisyadi S, Váradi A, Martin L, Bauer C, Erdmann J, Aherrahrou Z, Le Saux O. Pomozi V, et al. Am J Pathol. 2017 Jun;187(6):1258-1272. doi: 10.1016/j.ajpath.2017.02.009. Epub 2017 Apr 14. Am J Pathol. 2017. PMID: 28416300 Free PMC article.
ABCC6, a transmembrane transporter primarily expressed in liver and kidneys, initiates a molecular pathway inhibiting ectopic calcification. ...Furthermore, we found that the expression of low amounts of the human ABCC6 in liver of transgenic Abcc6(-/-) mice, result …
ABCC6, a transmembrane transporter primarily expressed in liver and kidneys, initiates a molecular pathway inhibiting ectopic …
Analysis of pseudoxanthoma elasticum-causing missense mutants of ABCC6 in vivo; pharmacological correction of the mislocalized proteins.
Pomozi V, Brampton C, Fülöp K, Chen LH, Apana A, Li Q, Uitto J, Le Saux O, Váradi A. Pomozi V, et al. J Invest Dermatol. 2014 Apr;134(4):946-953. doi: 10.1038/jid.2013.482. Epub 2013 Nov 11. J Invest Dermatol. 2014. PMID: 24352041 Free PMC article.
GACI patients present a more severe, often prenatal arterial calcification. We have tested 10 frequent disease-causing ABCC6 missense mutants for the transport activity by using Sf9 (Spodoptera frugiperda) cells, characterized the subcellular localization in MDCKII (Madin- …
GACI patients present a more severe, often prenatal arterial calcification. We have tested 10 frequent disease-causing ABCC6 missense …
Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters.
Tusnády GE, Bakos E, Váradi A, Sarkadi B. Tusnády GE, et al. FEBS Lett. 1997 Jan 27;402(1):1-3. doi: 10.1016/s0014-5793(96)01478-0. FEBS Lett. 1997. PMID: 9013845 Review.
A group of ATP-binding cassette (ABC) transporters, including the yeast cadmium transporter (YCF1), the mammalian multidrug resistance-associated protein (MRP), the multispecific organic anion transporter and its congener (MOAT and EBCR), as well as the sulfonylurea recept
A group of ATP-binding cassette (ABC) transporters, including the yeast cadmium transporter (YCF1), the mammalian multidrug resistanc
In vitro transport of methotrexate by Drosophila Multidrug Resistance-associated Protein.
Karasik A, Váradi A, Szeri F. Karasik A, et al. PLoS One. 2018 Oct 12;13(10):e0205657. doi: 10.1371/journal.pone.0205657. eCollection 2018. PLoS One. 2018. PMID: 30312334 Free PMC article.
Methotrexate (MTX) is a widely used chemotherapeutic agent, immune suppressant and antimalarial drug. It is a substrate of several human ABC proteins that confer multidrug resistance to cancer cells and determine compartmentalization of a wide range of physio …
Methotrexate (MTX) is a widely used chemotherapeutic agent, immune suppressant and antimalarial drug. It is a substrate of sev …
Functional Rescue of ABCC6 Deficiency by 4-Phenylbutyrate Therapy Reduces Dystrophic Calcification in Abcc6-/- Mice.
Pomozi V, Brampton C, Szeri F, Dedinszki D, Kozák E, van de Wetering K, Hopkins H, Martin L, Váradi A, Le Saux O. Pomozi V, et al. J Invest Dermatol. 2017 Mar;137(3):595-602. doi: 10.1016/j.jid.2016.10.035. Epub 2016 Nov 5. J Invest Dermatol. 2017. PMID: 27826008 Free PMC article.
Within the liver vasculature, adenosine triphosphate is converted into pyrophosphate, a major inhibitor of ectopic calcification. ...This study identifies 4-PBA treatment as a promising strategy for allele-specific therapy of ABCC6-associated calcification disorders …
Within the liver vasculature, adenosine triphosphate is converted into pyrophosphate, a major inhibitor of ectopic calcification. ... …
Antibody binding shift assay for rapid screening of drug interactions with the human ABCG2 multidrug transporter.
Telbisz Á, Hegedüs C, Özvegy-Laczka C, Goda K, Várady G, Takáts Z, Szabó E, Sorrentino BP, Váradi A, Sarkadi B. Telbisz Á, et al. Eur J Pharm Sci. 2012 Jan 23;45(1-2):101-9. doi: 10.1016/j.ejps.2011.10.021. Epub 2011 Nov 17. Eur J Pharm Sci. 2012. PMID: 22115866
In this paper we describe a rapid in vitro assay to identify transport modulation by measuring the cell surface interaction of a conformation sensitive monoclonal antibody (5D3) with ABCG2 in intact cells. ...A high-throughput, 96-well plate assay platform is …
In this paper we describe a rapid in vitro assay to identify transport modulation by measuring the cell surface interaction of a
Stimulus-induced expression of the ABCG2 multidrug transporter in HepG2 hepatocarcinoma model cells involves the ERK1/2 cascade and alternative promoters.
de Boussac H, Orbán TI, Várady G, Tihanyi B, Bacquet C, Brózik A, Váradi A, Sarkadi B, Arányi T. de Boussac H, et al. Biochem Biophys Res Commun. 2012 Sep 21;426(2):172-6. doi: 10.1016/j.bbrc.2012.08.046. Epub 2012 Aug 16. Biochem Biophys Res Commun. 2012. PMID: 22922104
Treatment with U0126, a specific inhibitor of the ERK1/2 cascade, prevented the HGF and the oxidative stress induced ABCG2 upregulation. ...In conclusion, we demonstrate a unique role of the ERK1/2 cascade on ABCG2 modulation in HepG2, and the differential use of th …
Treatment with U0126, a specific inhibitor of the ERK1/2 cascade, prevented the HGF and the oxidative stress induced ABCG2 upregulati …
Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal growth factor receptor inhibitor Iressa (ZD1839, Gefitinib).
Elkind NB, Szentpétery Z, Apáti A, Ozvegy-Laczka C, Várady G, Ujhelly O, Szabó K, Homolya L, Váradi A, Buday L, Kéri G, Német K, Sarkadi B. Elkind NB, et al. Cancer Res. 2005 Mar 1;65(5):1770-7. doi: 10.1158/0008-5472.CAN-04-3303. Cancer Res. 2005. PMID: 15753373
Recent data indicate that Iressa is especially effective in tumors with certain EGFR mutations; however, a subset of these tumors does not respond to Iressa. ...Previously, we showed that ABCG2 displays a high-affinity interaction with several tyrosine kinase recept …
Recent data indicate that Iressa is especially effective in tumors with certain EGFR mutations; however, a subset of these tumors doe …
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