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Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth.
Bruchard M, Mignot G, Derangère V, Chalmin F, Chevriaux A, Végran F, Boireau W, Simon B, Ryffel B, Connat JL, Kanellopoulos J, Martin F, Rébé C, Apetoh L, Ghiringhelli F. Bruchard M, et al. Among authors: vegran f. Nat Med. 2013 Jan;19(1):57-64. doi: 10.1038/nm.2999. Epub 2012 Dec 2. Nat Med. 2013. PMID: 23202296
Overexpression of caspase-3s splice variant in locally advanced breast carcinoma is associated with poor response to neoadjuvant chemotherapy.
Végran F, Boidot R, Oudin C, Riedinger JM, Bonnetain F, Lizard-Nacol S. Végran F, et al. Clin Cancer Res. 2006 Oct 1;12(19):5794-800. doi: 10.1158/1078-0432.CCR-06-0725. Clin Cancer Res. 2006. PMID: 17020986
Predictive value of survivin alternative transcript expression in locally advanced breast cancer patients treated with neoadjuvant chemotherapy.
Boidot R, Vegran F, Lizard-Nacol S. Boidot R, et al. Among authors: vegran f. Int J Mol Med. 2009 Feb;23(2):285-91. Int J Mol Med. 2009. PMID: 19148555
Restoration of antitumor immunity through selective inhibition of myeloid derived suppressor cells by anticancer therapies.
Apetoh L, Végran F, Ladoire S, Ghiringhelli F. Apetoh L, et al. Among authors: vegran f. Curr Mol Med. 2011 Jul;11(5):365-72. doi: 10.2174/156652411795976574. Curr Mol Med. 2011. PMID: 21568934 Review.
Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression.
Chalmin F, Mignot G, Bruchard M, Chevriaux A, Végran F, Hichami A, Ladoire S, Derangère V, Vincent J, Masson D, Robson SC, Eberl G, Pallandre JR, Borg C, Ryffel B, Apetoh L, Rébé C, Ghiringhelli F. Chalmin F, et al. Among authors: vegran f. Immunity. 2012 Mar 23;36(3):362-73. doi: 10.1016/j.immuni.2011.12.019. Epub 2012 Mar 8. Immunity. 2012. PMID: 22406269
Dacarbazine-mediated upregulation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth.
Hervieu A, Rébé C, Végran F, Chalmin F, Bruchard M, Vabres P, Apetoh L, Ghiringhelli F, Mignot G. Hervieu A, et al. Among authors: vegran f. J Invest Dermatol. 2013 Feb;133(2):499-508. doi: 10.1038/jid.2012.273. Epub 2012 Sep 6. J Invest Dermatol. 2013. PMID: 22951720
SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth.
Berger H, Végran F, Chikh M, Gilardi F, Ladoire S, Bugaut H, Mignot G, Chalmin F, Bruchard M, Derangère V, Chevriaux A, Rébé C, Ryffel B, Pot C, Hichami A, Desvergne B, Ghiringhelli F, Apetoh L. Berger H, et al. Among authors: vegran f. Cancer Res. 2013 Jun 15;73(12):3578-90. doi: 10.1158/0008-5472.CAN-12-4018. Epub 2013 Apr 25. Cancer Res. 2013. PMID: 23619236
Bleomycin exerts ambivalent antitumor immune effect by triggering both immunogenic cell death and proliferation of regulatory T cells.
Bugaut H, Bruchard M, Berger H, Derangère V, Odoul L, Euvrard R, Ladoire S, Chalmin F, Végran F, Rébé C, Apetoh L, Ghiringhelli F, Mignot G. Bugaut H, et al. Among authors: vegran f. PLoS One. 2013 Jun 7;8(6):e65181. doi: 10.1371/journal.pone.0065181. Print 2013. PLoS One. 2013. PMID: 23762310 Free PMC article.
STAT3 activation: A key factor in tumor immunoescape.
Rébé C, Végran F, Berger H, Ghiringhelli F. Rébé C, et al. Among authors: vegran f. JAKSTAT. 2013 Jan 1;2(1):e23010. doi: 10.4161/jkst.23010. JAKSTAT. 2013. PMID: 24058791 Free PMC article. Review.
Survivin-3B promotes chemoresistance and immune escape by inhibiting caspase-8 and -6 in cancer cells.
Végran F, Boidot R. Végran F, et al. Oncoimmunology. 2013 Nov 1;2(11):e26328. doi: 10.4161/onci.26328. Epub 2013 Oct 9. Oncoimmunology. 2013. PMID: 24353917 Free PMC article.
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