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A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation.
Vinolo E, Sebban H, Chaffotte A, Israël A, Courtois G, Véron M, Agou F. Vinolo E, et al. Among authors: veron m. J Biol Chem. 2006 Mar 10;281(10):6334-48. doi: 10.1074/jbc.M510118200. Epub 2005 Dec 26. J Biol Chem. 2006. PMID: 16379012 Free article.
NEMO trimerizes through its coiled-coil C-terminal domain.
Agou F, Ye F, Goffinont S, Courtois G, Yamaoka S, Israël A, Véron M. Agou F, et al. Among authors: veron m. J Biol Chem. 2002 May 17;277(20):17464-75. doi: 10.1074/jbc.M201964200. Epub 2002 Mar 4. J Biol Chem. 2002. PMID: 11877453 Free article.
Inhibition of NF-kappa B activation by peptides targeting NF-kappa B essential modulator (nemo) oligomerization.
Agou F, Courtois G, Chiaravalli J, Baleux F, Coïc YM, Traincard F, Israël A, Véron M. Agou F, et al. Among authors: veron m. J Biol Chem. 2004 Dec 24;279(52):54248-57. doi: 10.1074/jbc.M406423200. Epub 2004 Oct 5. J Biol Chem. 2004. PMID: 15466857 Free article.
., Traincard, F., Vinolo, E., Courtois, G., Yamaoka, S., Israel, A., and Veron, M. (2004) J. Biol. Chem. 279, 27861-27869). To search for drugs inhibiting NF-kappa B activation, we have rationally designed cell-permeable peptides corresponding to the CC2 and LZ subd …
., Traincard, F., Vinolo, E., Courtois, G., Yamaoka, S., Israel, A., and Veron, M. (2004) J. Biol. Chem. 279, 27861-27869). To …
The zinc finger of NEMO is a functional ubiquitin-binding domain.
Cordier F, Grubisha O, Traincard F, Véron M, Delepierre M, Agou F. Cordier F, et al. Among authors: veron m. J Biol Chem. 2009 Jan 30;284(5):2902-2907. doi: 10.1074/jbc.M806655200. Epub 2008 Nov 25. J Biol Chem. 2009. PMID: 19033441 Free article.
New mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein.
Hubeau M, Ngadjeua F, Puel A, Israel L, Feinberg J, Chrabieh M, Belani K, Bodemer C, Fabre I, Plebani A, Boisson-Dupuis S, Picard C, Fischer A, Israel A, Abel L, Veron M, Casanova JL, Agou F, Bustamante J. Hubeau M, et al. Among authors: veron m. Blood. 2011 Jul 28;118(4):926-35. doi: 10.1182/blood-2010-10-315234. Epub 2011 May 26. Blood. 2011. PMID: 21622647 Free PMC article.
283 results