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In vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets.
Carlet M, Völse K, Vergalli J, Becker M, Herold T, Arner A, Senft D, Jurinovic V, Liu WH, Gao Y, Dill V, Fehse B, Baldus CD, Bastian L, Lenk L, Schewe DM, Bagnoli JW, Vick B, Schmid JP, Wilhelm A, Marschalek R, Jost PJ, Miething C, Riecken K, Schmidt-Supprian M, Binder V, Jeremias I. Carlet M, et al. Among authors: volse k. Nat Commun. 2021 Sep 27;12(1):5655. doi: 10.1038/s41467-021-25963-z. Nat Commun. 2021. PMID: 34580292 Free PMC article.
Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML.
Kempf JM, Weser S, Bartoschek MD, Metzeler KH, Vick B, Herold T, Völse K, Mattes R, Scholz M, Wange LE, Festini M, Ugur E, Roas M, Weigert O, Bultmann S, Leonhardt H, Schotta G, Hiddemann W, Jeremias I, Spiekermann K. Kempf JM, et al. Among authors: volse k. Sci Rep. 2021 Mar 12;11(1):5838. doi: 10.1038/s41598-021-84708-6. Sci Rep. 2021. PMID: 33712646 Free PMC article.