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Pembrolizumab in combination with gemcitabine for patients with HER2-negative advanced breast cancer: GEICAM/2015-04 (PANGEA-Breast) study.
de la Cruz-Merino L, Gion M, Cruz J, Alonso-Romero JL, Quiroga V, Moreno F, Andrés R, Santisteban M, Ramos M, Holgado E, Cortés J, López-Miranda E, Cortés A, Henao F, Palazón-Carrión N, Rodriguez LM, Ceballos I, Soto A, Puertes A, Casas M, Benito S, Chiesa M, Bezares S, Caballero R, Jiménez-Cortegana C, Sánchez-Margalet V, Rojo F. de la Cruz-Merino L, et al. Among authors: sanchez margalet v. BMC Cancer. 2022 Dec 3;22(1):1258. doi: 10.1186/s12885-022-10363-3. BMC Cancer. 2022. PMID: 36463104 Free PMC article. Clinical Trial.
Pembrolizumab Plus Gemcitabine in the Subset of Triple-Negative Advanced Breast Cancer Patients in the GEICAM/2015-04 (PANGEA-Breast) Study.
de la Cruz-Merino L, Gion M, Cruz-Jurado J, Quiroga V, Andrés R, Moreno F, Alonso-Romero JL, Ramos M, Holgado E, Cortés J, López-Miranda E, Henao-Carrasco F, Palazón-Carrión N, Rodríguez LM, Ceballos I, Casas M, Benito S, Chiesa M, Bezares S, Caballero R, Jiménez-Cortegana C, Sánchez-Margalet V, Rojo F. de la Cruz-Merino L, et al. Among authors: sanchez margalet v. Cancers (Basel). 2021 Oct 29;13(21):5432. doi: 10.3390/cancers13215432. Cancers (Basel). 2021. PMID: 34771596 Free PMC article.
Leptin promotes cell proliferation and survival of trophoblastic cells.
Magariños MP, Sánchez-Margalet V, Kotler M, Calvo JC, Varone CL. Magariños MP, et al. Among authors: sanchez margalet v. Biol Reprod. 2007 Feb;76(2):203-10. doi: 10.1095/biolreprod.106.051391. Epub 2006 Oct 4. Biol Reprod. 2007. PMID: 17021346
Treatment with 2 microM leptin AS increased the number of apoptotic cells 60 times, as assessed by annexin V-fluorescein isothiocyanate/propidium iodide staining, and the caspase-3 activity was increased more than 2 fold. ...
Treatment with 2 microM leptin AS increased the number of apoptotic cells 60 times, as assessed by annexin V-fluorescein isothiocyana …
Leptin prevents apoptosis of trophoblastic cells by activation of MAPK pathway.
Pérez-Pérez A, Maymó J, Dueñas JL, Goberna R, Calvo JC, Varone C, Sánchez-Margalet V. Pérez-Pérez A, et al. Among authors: sanchez margalet v. Arch Biochem Biophys. 2008 Sep 15;477(2):390-5. doi: 10.1016/j.abb.2008.06.015. Epub 2008 Jun 27. Arch Biochem Biophys. 2008. PMID: 18619412
We have assayed the early phase of apoptosis, triggered by serum deprivation, by using Annexin V-propidium iodide (PI) labeling and flow cytometric analysis, as well as the late phase of apoptosis by studying the activation of caspase-3. ...
We have assayed the early phase of apoptosis, triggered by serum deprivation, by using Annexin V-propidium iodide (PI) labeling and f …
Leptin promotes cell survival and activates Jurkat T lymphocytes by stimulation of mitogen-activated protein kinase.
Fernández-Riejos P, Goberna R, Sánchez-Margalet V. Fernández-Riejos P, et al. Among authors: sanchez margalet v. Clin Exp Immunol. 2008 Mar;151(3):505-18. doi: 10.1111/j.1365-2249.2007.03563.x. Clin Exp Immunol. 2008. PMID: 18234059 Free PMC article.
We have assayed the early phases of apoptosis by flow cytometric detection of fluorescein isothiocyanate (FITC)-labelled annexin V simultaneously with dye exclusion of propidium iodide (PI). As well, we have assayed the activation level of caspase-3 by inmunoblot with a sp …
We have assayed the early phases of apoptosis by flow cytometric detection of fluorescein isothiocyanate (FITC)-labelled annexin V si …
Human leptin promotes survival of human circulating blood monocytes prone to apoptosis by activation of p42/44 MAPK pathway.
Najib S, Sánchez-Margalet V. Najib S, et al. Among authors: sanchez margalet v. Cell Immunol. 2002 Dec;220(2):143-9. doi: 10.1016/s0008-8749(03)00027-3. Cell Immunol. 2002. PMID: 12657249
We have assayed the early phases of apoptosis by flow cytometric detection of phosphatidylserine expression using fluorescein isothiocyanate (FITC)-labelled Annexin V, simultaneously with dye exclusion of propidium iodide (PI), to discriminate intact cells, apoptotic, and …
We have assayed the early phases of apoptosis by flow cytometric detection of phosphatidylserine expression using fluorescein isothiocyanate …