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1,259 results

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Page 1
VAMP2 regulates phase separation of alpha-synuclein.
Agarwal A, Chandran A, Raza F, Ungureanu IM, Hilcenko C, Stott K, Bright NA, Morone N, Warren AJ, Lautenschläger J. Agarwal A, et al. Nat Cell Biol. 2024 Aug;26(8):1296-1308. doi: 10.1038/s41556-024-01451-6. Epub 2024 Jul 1. Nat Cell Biol. 2024. PMID: 38951707 Free PMC article.
alpha-Synuclein (alphaSYN), a pivotal synaptic protein implicated in synucleinopathies such as Parkinson's disease and Lewy body dementia, undergoes protein phase separation. We reveal that vesicle-associated membrane protein 2 (VAMP2) or …
alpha-Synuclein (alphaSYN), a pivotal synaptic protein implicated in synucleinopathies such as Parkinson's disease and Lewy body dementia, u …
VAMP2 chaperones alpha-synuclein in synaptic vesicle co-condensates.
Wang C, Zhang K, Cai B, Haller JE, Carnazza KE, Hu J, Zhao C, Tian Z, Hu X, Hall D, Qiang J, Hou S, Liu Z, Gu J, Zhang Y, Seroogy KB, Burré J, Fang Y, Liu C, Brunger AT, Li D, Diao J. Wang C, et al. Nat Cell Biol. 2024 Aug;26(8):1287-1295. doi: 10.1038/s41556-024-01456-1. Epub 2024 Jul 1. Nat Cell Biol. 2024. PMID: 38951706
Here we show that the juxtamembrane region of vesicle-associated membrane protein 2 (VAMP2)-a component of the SNARE complex that resides on SVs-directly interacts with the carboxy-terminal region of alpha-Syn through charged residues to …
Here we show that the juxtamembrane region of vesicle-associated membrane protein 2 (VAMP2)-a comp …
VAMP2 controls murine epidermal differentiation and carcinogenesis by regulation of nucleophagy.
Liu H, Su P, Li Y, Hoover A, Hu S, King SA, Zhao J, Guan JL, Chen SY, Zhao Y, Tan M, Wu X. Liu H, et al. Dev Cell. 2024 Aug 5;59(15):2005-2016.e4. doi: 10.1016/j.devcel.2024.05.004. Epub 2024 May 28. Dev Cell. 2024. PMID: 38810653
With a genome-wide shRNA screen, we identified vesicle-associated membrane protein 2 (VAMP2) as a critical factor involved in skin differentiation. Deletion of VAMP2 leads to aberrant skin stratification and enucleation in vivo. Wi …
With a genome-wide shRNA screen, we identified vesicle-associated membrane protein 2 (VAMP2) as a …
CNS myelination requires VAMP2/3-mediated membrane expansion in oligodendrocytes.
Lam M, Takeo K, Almeida RG, Cooper MH, Wu K, Iyer M, Kantarci H, Zuchero JB. Lam M, et al. Nat Commun. 2022 Sep 23;13(1):5583. doi: 10.1038/s41467-022-33200-4. Nat Commun. 2022. PMID: 36151203 Free PMC article.
Here, we show that CNS myelin membrane addition requires exocytosis mediated by the vesicular SNARE proteins VAMP2/3. Genetic inactivation of VAMP2/3 in myelinating oligodendrocytes caused severe hypomyelination and premature death without overt loss of oligodendroc …
Here, we show that CNS myelin membrane addition requires exocytosis mediated by the vesicular SNARE proteins VAMP2/3. Genetic inactiv …
VAMP2 and synaptotagmin mobility in chromaffin granule membranes: implications for regulated exocytosis.
Abbineni PS, Briguglio JS, Chapman ER, Holz RW, Axelrod D. Abbineni PS, et al. Mol Biol Cell. 2022 May 15;33(6):ar53. doi: 10.1091/mbc.E21-10-0494. Epub 2021 Dec 1. Mol Biol Cell. 2022. PMID: 34851717 Free PMC article.
Thus, the mobility of granule membrane proteins may influence docking and membrane fusion. We measured the mobility of vesicle associated membrane protein 2 (VAMP2), synaptotagmin 1 (Syt1), and synaptotagmin 7 (Syt7) in chromaffin granule …
Thus, the mobility of granule membrane proteins may influence docking and membrane fusion. We measured the mobility of vesicle ass …
Tomosyns attenuate SNARE assembly and synaptic depression by binding to VAMP2-containing template complexes.
Meijer M, Öttl M, Yang J, Subkhangulova A, Kumar A, Feng Z, van Voorst TW, Groffen AJ, van Weering JRT, Zhang Y, Verhage M. Meijer M, et al. Nat Commun. 2024 Mar 26;15(1):2652. doi: 10.1038/s41467-024-46828-1. Nat Commun. 2024. PMID: 38531902 Free PMC article.
While wild-type tomosyn-1m rescued these phenotypes, substitution of its SNARE motif with that of synaptobrevin-2/VAMP2 did not. Single-molecule force measurements indeed revealed that tomosyn's SNARE motif cannot substitute synaptobrevin-2/VAMP2 to form template co …
While wild-type tomosyn-1m rescued these phenotypes, substitution of its SNARE motif with that of synaptobrevin-2/VAMP2 did not. Sing …
Cleavage of VAMP2/3 Affects Oligodendrocyte Lineage Development in the Developing Mouse Spinal Cord.
Fekete CD, Horning RZ, Doron MS, Nishiyama A. Fekete CD, et al. J Neurosci. 2023 Sep 27;43(39):6592-6608. doi: 10.1523/JNEUROSCI.2206-21.2023. Epub 2023 Aug 24. J Neurosci. 2023. PMID: 37620160 Free PMC article.
Here, we show that in vivo toxin-mediated cleavage of the vesicle associated SNARE proteins VAMP2/3 in the OL lineage of both male and female mice impairs the ability of early OLs to mature into functional, myelinating OLs. In the developing mouse spinal cord, many VAMP …
Here, we show that in vivo toxin-mediated cleavage of the vesicle associated SNARE proteins VAMP2/3 in the OL lineage of both male an …
Overcoming presynaptic effects of VAMP2 mutations with 4-aminopyridine treatment.
Simmons RL, Li H, Alten B, Santos MS, Jiang R, Paul B, Lalani SJ, Cortesi A, Parks K, Khandelwal N, Smith-Packard B, Phoong MA, Chez M, Fisher H, Scheuerle AE, Shinawi M, Hussain SA, Kavalali ET, Sherr EH, Voglmaier SM. Simmons RL, et al. Hum Mutat. 2020 Nov;41(11):1999-2011. doi: 10.1002/humu.24109. Epub 2020 Oct 1. Hum Mutat. 2020. PMID: 32906212 Free PMC article.
Clinical and genetic features of five unrelated patients with de novo pathogenic variants in the synaptic vesicle-associated membrane protein 2 (VAMP2) reveal common features of global developmental delay, autistic tendencies, behavioral …
Clinical and genetic features of five unrelated patients with de novo pathogenic variants in the synaptic vesicle-associated …
1,259 results