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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 1
1974 2
1976 1
1977 1
1980 1
1983 1
1984 1
1985 1
1988 3
1989 8
1990 9
1991 13
1992 9
1993 18
1994 30
1995 58
1996 57
1997 68
1998 76
1999 97
2000 102
2001 137
2002 146
2003 156
2004 165
2005 178
2006 209
2007 203
2008 212
2009 222
2010 218
2011 231
2012 267
2013 315
2014 297
2015 296
2016 293
2017 318
2018 309
2019 309
2020 379
2021 397
2022 401
2023 28
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5,676 results
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Page 1
VHL and Hypoxia Signaling: Beyond HIF in Cancer.
Zhang J, Zhang Q. Zhang J, et al. Biomedicines. 2018 Mar 19;6(1):35. doi: 10.3390/biomedicines6010035. Biomedicines. 2018. PMID: 29562667 Free PMC article. Review.
Von Hippel-Lindau (VHL) is an important tumor suppressor that is lost in the majority of clear cell carcinoma of renal cancer (ccRCC). ...We will also discuss the crosstalk between VHL and NF-kappaB signaling. Lastly, we will review the latest findings on targeting …
Von Hippel-Lindau (VHL) is an important tumor suppressor that is lost in the majority of clear cell carcinoma of renal cancer (ccRCC) …
The Role of VHL in the Development of von Hippel-Lindau Disease and Erythrocytosis.
Hudler P, Urbancic M. Hudler P, et al. Genes (Basel). 2022 Feb 17;13(2):362. doi: 10.3390/genes13020362. Genes (Basel). 2022. PMID: 35205407 Free PMC article. Review.
VHL variations have been associated with the development of VHL disease and erythrocytosis. ...It appears that there is a distinction between erythrocytosis-causing VHL variations and VHL variations causing VHL disease with tumor development. .. …
VHL variations have been associated with the development of VHL disease and erythrocytosis. ...It appears that there is a dist …
VHL mosaicism: the added value of multi-tissue analysis.
Oldfield LE, Grzybowski J, Grenier S, Chao E, Downs GS, Farncombe KM, Stockley TL, Mete O, Kim RH. Oldfield LE, et al. NPJ Genom Med. 2022 Mar 18;7(1):21. doi: 10.1038/s41525-022-00291-3. NPJ Genom Med. 2022. PMID: 35304467 Free PMC article.
A germline VHL variant is identified in 95-100% of individuals with a clinical diagnosis of VHL. Here, we present the case of an individual with a clinical diagnosis of VHL disease where peripheral blood DNA analysis did not detect a VHL variant. ...
A germline VHL variant is identified in 95-100% of individuals with a clinical diagnosis of VHL. Here, we present the case of …
Von Hippel-Lindau disease.
Chittiboina P, Lonser RR. Chittiboina P, et al. Handb Clin Neurol. 2015;132:139-56. doi: 10.1016/B978-0-444-62702-5.00010-X. Handb Clin Neurol. 2015. PMID: 26564077 Free PMC article. Review.
VHL is caused by germline loss of function of the VHL gene on one allele at chromosome 3p25-26. ...VHL protein/HIF pathway has been implicated in tumorigenesis for hemangioblastomas, RCC and other VHL tumors. ...
VHL is caused by germline loss of function of the VHL gene on one allele at chromosome 3p25-26. ...VHL protein/HIF path …
The Clinical and Molecular Features in the VHL Renal Cancers; Close or Distant Relatives with Sporadic Clear Cell Renal Cell Carcinoma?
Cinque A, Minnei R, Floris M, Trevisani F. Cinque A, et al. Cancers (Basel). 2022 Oct 30;14(21):5352. doi: 10.3390/cancers14215352. Cancers (Basel). 2022. PMID: 36358771 Free PMC article. Review.
Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited cancer syndrome caused by germline mutations in the VHL tumor suppressor gene, characterized by the susceptibility to a wide array of benign and malign neoplasms, including clear-cell renal cell carc …
Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited cancer syndrome caused by germline mutations in the VHL tum …
The VHL tumour-suppressor gene paradigm.
Kaelin WG Jr, Maher ER. Kaelin WG Jr, et al. Trends Genet. 1998 Oct;14(10):423-6. doi: 10.1016/s0168-9525(98)01558-3. Trends Genet. 1998. PMID: 9820032 Review.
There are many similarities between the genetics of the VHL and retinoblastoma TSGs, but the VHL tumourigenesis model is more complex. Here, we examine the current knowledge of the genetics and functional aspects of the VHL TSG, and emphasize how the VHL …
There are many similarities between the genetics of the VHL and retinoblastoma TSGs, but the VHL tumourigenesis model is more …
The VHL Tumor Suppressor Gene: Insights into Oxygen Sensing and Cancer.
Kaelin WG Jr. Kaelin WG Jr. Trans Am Clin Climatol Assoc. 2017;128:298-307. Trans Am Clin Climatol Assoc. 2017. PMID: 28790514 Free PMC article. Review.
In the presence of oxygen, the alpha subunit is hydroxylated on one (or both) of two highly conserved prolyl residues by an Egg-Laying Defective Nine (EglN) [also called Prolyl Hydroxylase Domain (PHD)] dioxygenase, which recruits an ubiquitin ligase complex containing the VHL …
In the presence of oxygen, the alpha subunit is hydroxylated on one (or both) of two highly conserved prolyl residues by an Egg-Laying Defec …
VHL Ser65 mutations enhance HIF2α signaling and promote epithelial-mesenchymal transition of renal cancer cells.
Ma X, Tan Z, Zhang Q, Ma K, Xiao J, Wang X, Wang Y, Zhong M, Wang Y, Li J, Zeng X, Guan W, Wang S, Gong K, Wei GH, Wang Z. Ma X, et al. Cell Biosci. 2022 May 3;12(1):52. doi: 10.1186/s13578-022-00790-x. Cell Biosci. 2022. PMID: 35505422 Free PMC article.
BACKGROUND: Von Hippel-Lindau (VHL) disease is an autosomal dominant genetic neoplastic disorder caused by germline mutation or deletion of the VHL gene, characterized by the tendency to develop multisystem benign or malignant tumors. The mechanism of VHL mut …
BACKGROUND: Von Hippel-Lindau (VHL) disease is an autosomal dominant genetic neoplastic disorder caused by germline mutation or delet …
Systemic VHL gene functions and the VHL disease.
Bader HL, Hsu T. Bader HL, et al. FEBS Lett. 2012 Jun 4;586(11):1562-9. doi: 10.1016/j.febslet.2012.04.032. Epub 2012 Apr 25. FEBS Lett. 2012. PMID: 22673568 Free PMC article. Review.
VHL mutations are the genetic defects underlying several human diseases including polycythemia, familial VHL tumor syndrome and sporadic renal cell carcinoma. ...As such, systemic functions of VHL likely play important roles in the development of VHL d …
VHL mutations are the genetic defects underlying several human diseases including polycythemia, familial VHL tumor syndrome an …
Sinonasal renal cell-like adenocarcinoma arising in von Hippel Lindau (VHL) syndrome.
Maharaj S, Seegobin K, Wakeman K, Chang S, Potts K, Williams B, Redman R. Maharaj S, et al. Oral Oncol. 2022 Feb;125:105705. doi: 10.1016/j.oraloncology.2021.105705. Epub 2022 Jan 5. Oral Oncol. 2022. PMID: 34998175 Review.
A review of the literature yielded two similar cases in the setting of VHL. In our case with associated VHL syndrome, next generation sequencing detected MST1R mutation, a possible driver. SNRCLA is an emerging tumor associated with VHL syndrome and it is hop …
A review of the literature yielded two similar cases in the setting of VHL. In our case with associated VHL syndrome, next gen …
5,676 results