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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 1
1974 2
1976 1
1977 1
1980 1
1983 1
1984 1
1985 1
1988 3
1989 8
1990 9
1991 13
1992 9
1993 18
1994 30
1995 58
1996 57
1997 68
1998 76
1999 97
2000 102
2001 137
2002 146
2003 156
2004 165
2005 178
2006 209
2007 203
2008 212
2009 222
2010 218
2011 231
2012 267
2013 315
2014 297
2015 296
2016 293
2017 318
2018 309
2019 308
2020 379
2021 397
2022 363
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5,624 results
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Page 1
VHL and Hypoxia Signaling: Beyond HIF in Cancer.
Zhang J, Zhang Q. Zhang J, et al. Biomedicines. 2018 Mar 19;6(1):35. doi: 10.3390/biomedicines6010035. Biomedicines. 2018. PMID: 29562667 Free PMC article. Review.
Von Hippel-Lindau (VHL) is an important tumor suppressor that is lost in the majority of clear cell carcinoma of renal cancer (ccRCC). ...We will also discuss the crosstalk between VHL and NF-kappaB signaling. Lastly, we will review the latest findings on targeting …
Von Hippel-Lindau (VHL) is an important tumor suppressor that is lost in the majority of clear cell carcinoma of renal cancer (ccRCC) …
Von Hippel-Lindau disease.
Chittiboina P, Lonser RR. Chittiboina P, et al. Handb Clin Neurol. 2015;132:139-56. doi: 10.1016/B978-0-444-62702-5.00010-X. Handb Clin Neurol. 2015. PMID: 26564077 Free PMC article. Review.
VHL is caused by germline loss of function of the VHL gene on one allele at chromosome 3p25-26. ...VHL protein/HIF pathway has been implicated in tumorigenesis for hemangioblastomas, RCC and other VHL tumors. ...
VHL is caused by germline loss of function of the VHL gene on one allele at chromosome 3p25-26. ...VHL protein/HIF path …
The VHL Tumor Suppressor Gene: Insights into Oxygen Sensing and Cancer.
Kaelin WG Jr. Kaelin WG Jr. Trans Am Clin Climatol Assoc. 2017;128:298-307. Trans Am Clin Climatol Assoc. 2017. PMID: 28790514 Free PMC article. Review.
In the presence of oxygen, the alpha subunit is hydroxylated on one (or both) of two highly conserved prolyl residues by an Egg-Laying Defective Nine (EglN) [also called Prolyl Hydroxylase Domain (PHD)] dioxygenase, which recruits an ubiquitin ligase complex containing the VHL …
In the presence of oxygen, the alpha subunit is hydroxylated on one (or both) of two highly conserved prolyl residues by an Egg-Laying Defec …
The Role of VHL in the Development of von Hippel-Lindau Disease and Erythrocytosis.
Hudler P, Urbancic M. Hudler P, et al. Genes (Basel). 2022 Feb 17;13(2):362. doi: 10.3390/genes13020362. Genes (Basel). 2022. PMID: 35205407 Free PMC article. Review.
VHL variations have been associated with the development of VHL disease and erythrocytosis. ...It appears that there is a distinction between erythrocytosis-causing VHL variations and VHL variations causing VHL disease with tumor development. .. …
VHL variations have been associated with the development of VHL disease and erythrocytosis. ...It appears that there is a dist …
Management Strategies and Outcomes for VHL-related Craniospinal Hemangioblastomas.
Ordookhanian C, Kaloostian PE, Ghostine SS, Spiess PE, Etame AB. Ordookhanian C, et al. J Kidney Cancer VHL. 2017 Aug 28;4(3):37-44. doi: 10.15586/jkcvhl.2017.90. eCollection 2017. J Kidney Cancer VHL. 2017. PMID: 28868236 Free PMC article. Review.
VHL-related hemangioblastomas predominantly occur in the cerebellum and spine. Lesions are often diagnosed on contrast-enhanced craniospinal MRIs, and the diagnosis of VHL occurs through assessment for germline VHL mutations. Surgical resection remains the pr …
VHL-related hemangioblastomas predominantly occur in the cerebellum and spine. Lesions are often diagnosed on contrast-enhanced crani …
Systemic VHL gene functions and the VHL disease.
Bader HL, Hsu T. Bader HL, et al. FEBS Lett. 2012 Jun 4;586(11):1562-9. doi: 10.1016/j.febslet.2012.04.032. Epub 2012 Apr 25. FEBS Lett. 2012. PMID: 22673568 Free PMC article. Review.
VHL mutations are the genetic defects underlying several human diseases including polycythemia, familial VHL tumor syndrome and sporadic renal cell carcinoma. ...As such, systemic functions of VHL likely play important roles in the development of VHL d …
VHL mutations are the genetic defects underlying several human diseases including polycythemia, familial VHL tumor syndrome an …
The VHL tumour-suppressor gene paradigm.
Kaelin WG Jr, Maher ER. Kaelin WG Jr, et al. Trends Genet. 1998 Oct;14(10):423-6. doi: 10.1016/s0168-9525(98)01558-3. Trends Genet. 1998. PMID: 9820032 Review.
There are many similarities between the genetics of the VHL and retinoblastoma TSGs, but the VHL tumourigenesis model is more complex. Here, we examine the current knowledge of the genetics and functional aspects of the VHL TSG, and emphasize how the VHL …
There are many similarities between the genetics of the VHL and retinoblastoma TSGs, but the VHL tumourigenesis model is more …
High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells.
Zhu S, Ding W, Chen Y, Wang W, Xu R, Liu C, Liu X, Deng H. Zhu S, et al. Genomics Proteomics Bioinformatics. 2021 Feb 26:S1672-0229(21)00039-5. doi: 10.1016/j.gpb.2019.12.002. Online ahead of print. Genomics Proteomics Bioinformatics. 2021. PMID: 33647481 Free article.
However, it is unclear whether VHL influences the progression of ccRCC tumors expressing wild-type VHL. ...Importantly, we found that VHL overexpression led to upregulation of proteins associated with antigen processing and interferon-responsive proteins, ren …
However, it is unclear whether VHL influences the progression of ccRCC tumors expressing wild-type VHL. ...Importantly, we fou …
[Expression of VHL, VEGF and HIF-1α in endolymphatic sac tumors].
Mao ML, Zhao YH, Ma DL, Liu HG. Mao ML, et al. Zhonghua Bing Li Xue Za Zhi. 2021 Nov 8;50(11):1228-1233. doi: 10.3760/cma.j.cn112151-20210324-00231. Zhonghua Bing Li Xue Za Zhi. 2021. PMID: 34719159 Chinese.
Sanger sequencing was performed to detect the VHL mutation status in 24 ELSTs. The correlations among VHL, VEGF and HIF-1alpha expression were analyzed. ...VHL expression was inversely correlated with VEGF and HIF-1alpha expression. ...
Sanger sequencing was performed to detect the VHL mutation status in 24 ELSTs. The correlations among VHL, VEGF and HIF-1alpha …
Ultrasound Microbubble-Mediated VHL Regulates the Biological Behavior of Ovarian Cancer Cells.
Li C, Hu S, Yue Y. Li C, et al. Ultrasound Med Biol. 2021 Mar;47(3):723-732. doi: 10.1016/j.ultrasmedbio.2020.11.001. Epub 2020 Nov 28. Ultrasound Med Biol. 2021. PMID: 33261909
The effect of microbubble-treated VHL was similar to liposome-mediated regulation, while ultrasound treatment enhanced the effect of VHL on OVCAR-3 cells. More interestingly, ultrasound microbubble-mediated VHL had the most obvious regulatory effect on OVCAR- …
The effect of microbubble-treated VHL was similar to liposome-mediated regulation, while ultrasound treatment enhanced the effect of …
5,624 results