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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 1
1974 2
1976 1
1977 1
1980 1
1983 1
1984 1
1985 1
1988 3
1989 8
1990 9
1991 13
1992 9
1993 18
1994 30
1995 58
1996 57
1997 68
1998 76
1999 97
2000 102
2001 137
2002 146
2003 156
2004 165
2005 178
2006 209
2007 203
2008 212
2009 222
2010 218
2011 231
2012 267
2013 315
2014 297
2015 296
2016 293
2017 318
2018 308
2019 309
2020 378
2021 396
2022 408
2023 393
2024 171

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6,160 results

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Page 1
Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma.
Hu J, Tan P, Ishihara M, Bayley NA, Schokrpur S, Reynoso JG, Zhang Y, Lim RJ, Dumitras C, Yang L, Dubinett SM, Jat PS, Van Snick J, Huang J, Chin AI, Prins RM, Graeber TG, Xu H, Wu L. Hu J, et al. Signal Transduct Target Ther. 2023 Apr 17;8(1):155. doi: 10.1038/s41392-023-01362-2. Signal Transduct Target Ther. 2023. PMID: 37069149 Free PMC article.
The VHL gene-deleted (VHL-KO) cells underwent epithelial-to-mesenchymal transition (EMT) and exhibited increased motility but diminished proliferation and tumorigenicity compared to the parental VHL-expressing (VHL(+)) cells. Renal tumors with either …
The VHL gene-deleted (VHL-KO) cells underwent epithelial-to-mesenchymal transition (EMT) and exhibited increased motility but …
VHL and Hypoxia Signaling: Beyond HIF in Cancer.
Zhang J, Zhang Q. Zhang J, et al. Biomedicines. 2018 Mar 19;6(1):35. doi: 10.3390/biomedicines6010035. Biomedicines. 2018. PMID: 29562667 Free PMC article. Review.
Von Hippel-Lindau (VHL) is an important tumor suppressor that is lost in the majority of clear cell carcinoma of renal cancer (ccRCC). ...We will also discuss the crosstalk between VHL and NF-kappaB signaling. Lastly, we will review the latest findings on targeting …
Von Hippel-Lindau (VHL) is an important tumor suppressor that is lost in the majority of clear cell carcinoma of renal cancer (ccRCC) …
The Role of VHL in the Development of von Hippel-Lindau Disease and Erythrocytosis.
Hudler P, Urbancic M. Hudler P, et al. Genes (Basel). 2022 Feb 17;13(2):362. doi: 10.3390/genes13020362. Genes (Basel). 2022. PMID: 35205407 Free PMC article. Review.
VHL variations have been associated with the development of VHL disease and erythrocytosis. ...It appears that there is a distinction between erythrocytosis-causing VHL variations and VHL variations causing VHL disease with tumor development. .. …
VHL variations have been associated with the development of VHL disease and erythrocytosis. ...It appears that there is a dist …
Von Hippel-Lindau disease.
Chittiboina P, Lonser RR. Chittiboina P, et al. Handb Clin Neurol. 2015;132:139-56. doi: 10.1016/B978-0-444-62702-5.00010-X. Handb Clin Neurol. 2015. PMID: 26564077 Free PMC article. Review.
VHL is caused by germline loss of function of the VHL gene on one allele at chromosome 3p25-26. ...VHL protein/HIF pathway has been implicated in tumorigenesis for hemangioblastomas, RCC and other VHL tumors. ...
VHL is caused by germline loss of function of the VHL gene on one allele at chromosome 3p25-26. ...VHL protein/HIF path …
VHL-deficiency leads to reductive stress in renal cells.
Vellama H, Eskla KL, Eichelmann H, Hüva A, Tennant DA, Thakker A, Roberts J, Jagomäe T, Porosk R, Laisk A, Oja V, Rämma H, Volke V, Vasar E, Luuk H. Vellama H, et al. Free Radic Biol Med. 2023 Nov 1;208:1-12. doi: 10.1016/j.freeradbiomed.2023.07.029. Epub 2023 Jul 26. Free Radic Biol Med. 2023. PMID: 37506952 Free PMC article.
Heritable renal cancer syndromes (RCS) are associated with numerous chromosomal alterations including inactivating mutations in von Hippel-Lindau (VHL) gene. Here we identify a novel aspect of the phenotype in VHL-deficient human renal cells. ...This study demonstra …
Heritable renal cancer syndromes (RCS) are associated with numerous chromosomal alterations including inactivating mutations in von Hippel-L …
VHL mosaicism: the added value of multi-tissue analysis.
Oldfield LE, Grzybowski J, Grenier S, Chao E, Downs GS, Farncombe KM, Stockley TL, Mete O, Kim RH. Oldfield LE, et al. NPJ Genom Med. 2022 Mar 18;7(1):21. doi: 10.1038/s41525-022-00291-3. NPJ Genom Med. 2022. PMID: 35304467 Free PMC article.
A germline VHL variant is identified in 95-100% of individuals with a clinical diagnosis of VHL. Here, we present the case of an individual with a clinical diagnosis of VHL disease where peripheral blood DNA analysis did not detect a VHL variant. ...
A germline VHL variant is identified in 95-100% of individuals with a clinical diagnosis of VHL. Here, we present the case of …
The VHL Tumor Suppressor Gene: Insights into Oxygen Sensing and Cancer.
Kaelin WG Jr. Kaelin WG Jr. Trans Am Clin Climatol Assoc. 2017;128:298-307. Trans Am Clin Climatol Assoc. 2017. PMID: 28790514 Free PMC article. Review.
In the presence of oxygen, the alpha subunit is hydroxylated on one (or both) of two highly conserved prolyl residues by an Egg-Laying Defective Nine (EglN) [also called Prolyl Hydroxylase Domain (PHD)] dioxygenase, which recruits an ubiquitin ligase complex containing the VHL …
In the presence of oxygen, the alpha subunit is hydroxylated on one (or both) of two highly conserved prolyl residues by an Egg-Laying Defec …
Latin American and Caribbean Health Resources: The VHL Regional Portal.
Linares B, Larsen K. Linares B, et al. Med Ref Serv Q. 2023 Jul-Sep;42(3):294-300. doi: 10.1080/02763869.2023.2220607. Med Ref Serv Q. 2023. PMID: 37459490 Review.
This column provides an overview of the Virtual Health Library (VHL) Regional Portal, a resource provided by Pan American Health Organization and others with the purpose of communicating and exchanging health experiences and information for Latin American and Caribbean cou …
This column provides an overview of the Virtual Health Library (VHL) Regional Portal, a resource provided by Pan American Health Orga …
Systemic VHL gene functions and the VHL disease.
Bader HL, Hsu T. Bader HL, et al. FEBS Lett. 2012 Jun 4;586(11):1562-9. doi: 10.1016/j.febslet.2012.04.032. Epub 2012 Apr 25. FEBS Lett. 2012. PMID: 22673568 Free PMC article. Review.
VHL mutations are the genetic defects underlying several human diseases including polycythemia, familial VHL tumor syndrome and sporadic renal cell carcinoma. ...As such, systemic functions of VHL likely play important roles in the development of VHL d …
VHL mutations are the genetic defects underlying several human diseases including polycythemia, familial VHL tumor syndrome an …
Management Strategies and Outcomes for VHL-related Craniospinal Hemangioblastomas.
Ordookhanian C, Kaloostian PE, Ghostine SS, Spiess PE, Etame AB. Ordookhanian C, et al. J Kidney Cancer VHL. 2017 Aug 28;4(3):37-44. doi: 10.15586/jkcvhl.2017.90. eCollection 2017. J Kidney Cancer VHL. 2017. PMID: 28868236 Free PMC article. Review.
VHL-related hemangioblastomas predominantly occur in the cerebellum and spine. Lesions are often diagnosed on contrast-enhanced craniospinal MRIs, and the diagnosis of VHL occurs through assessment for germline VHL mutations. Surgical resection remains the pr …
VHL-related hemangioblastomas predominantly occur in the cerebellum and spine. Lesions are often diagnosed on contrast-enhanced crani …
6,160 results