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Year Number of Results
1955 1
1974 2
1976 1
1977 1
1980 1
1983 1
1984 1
1985 1
1988 3
1989 8
1990 9
1991 13
1992 9
1993 18
1994 30
1995 58
1996 57
1997 68
1998 76
1999 97
2000 102
2001 137
2002 145
2003 156
2004 165
2005 178
2006 209
2007 203
2008 212
2009 222
2010 218
2011 230
2012 267
2013 315
2014 297
2015 293
2016 293
2017 315
2018 304
2019 302
2020 377
2021 68
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4,990 results
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VHL and Hypoxia Signaling: Beyond HIF in Cancer.
Zhang J, Zhang Q. Zhang J, et al. Biomedicines. 2018 Mar 19;6(1):35. doi: 10.3390/biomedicines6010035. Biomedicines. 2018. PMID: 29562667 Free PMC article. Review.
Von Hippel-Lindau (VHL) is an important tumor suppressor that is lost in the majority of clear cell carcinoma of renal cancer (ccRCC). ...We will also discuss the crosstalk between VHL and NF-kappaB signaling. Lastly, we will review the latest findings on targeting …
Von Hippel-Lindau (VHL) is an important tumor suppressor that is lost in the majority of clear cell carcinoma of renal cancer (ccRCC) …
The VHL Tumor Suppressor Gene: Insights into Oxygen Sensing and Cancer.
Kaelin WG Jr. Kaelin WG Jr. Trans Am Clin Climatol Assoc. 2017;128:298-307. Trans Am Clin Climatol Assoc. 2017. PMID: 28790514 Free PMC article. Review.
In the presence of oxygen, the alpha subunit is hydroxylated on one (or both) of two highly conserved prolyl residues by an Egg-Laying Defective Nine (EglN) [also called Prolyl Hydroxylase Domain (PHD)] dioxygenase, which recruits an ubiquitin ligase complex containing the VHL
In the presence of oxygen, the alpha subunit is hydroxylated on one (or both) of two highly conserved prolyl residues by an Egg-Laying Defec …
The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma.
Peng S, Zhang J, Tan X, Huang Y, Xu J, Silk N, Zhang D, Liu Q, Jiang J. Peng S, et al. Front Endocrinol (Lausanne). 2020 Nov 24;11:586857. doi: 10.3389/fendo.2020.586857. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 33329393 Free PMC article. Review.
Although dysfunction of any one of a panel of more than 20 genes can lead to PPGLs, mutations in genes involved in the VHL/HIF axis including PHD, VHL, HIF-2A (EPAS1), and SDHx are more frequently found in PPGLs. ...In this review, we will first discuss the VHL
Although dysfunction of any one of a panel of more than 20 genes can lead to PPGLs, mutations in genes involved in the VHL/HIF axis i …
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance.
Li S, Rodriguez J, Li W, Bullova P, Fell SM, Surova O, Westerlund I, Topcic D, Bergsland M, Stenman A, Muhr J, Nistér M, Holmberg J, Juhlin CC, Larsson C, von Kriegsheim A, Kaelin WG Jr, Schlisio S. Li S, et al. Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16997-17006. doi: 10.1073/pnas.1900748116. Epub 2019 Aug 2. Proc Natl Acad Sci U S A. 2019. PMID: 31375625 Free PMC article.
Despite the discovery of the oxygen-sensitive regulation of HIFalpha by the von Hippel-Lindau (VHL) protein, the mechanisms underlying the complex genotype/phenotype correlations in VHL disease remain unknown. ...Here, we identified an oxygen-sensitive function of …
Despite the discovery of the oxygen-sensitive regulation of HIFalpha by the von Hippel-Lindau (VHL) protein, the mechanisms underlyin …
Von Hippel-Lindau disease.
Chittiboina P, Lonser RR. Chittiboina P, et al. Handb Clin Neurol. 2015;132:139-56. doi: 10.1016/B978-0-444-62702-5.00010-X. Handb Clin Neurol. 2015. PMID: 26564077 Free PMC article. Review.
VHL is caused by germline loss of function of the VHL gene on one allele at chromosome 3p25-26. ...VHL protein/HIF pathway has been implicated in tumorigenesis for hemangioblastomas, RCC and other VHL tumors. ...
VHL is caused by germline loss of function of the VHL gene on one allele at chromosome 3p25-26. ...VHL protein/HIF path
Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.
Stebbins CE, Kaelin WG Jr, Pavletich NP. Stebbins CE, et al. Science. 1999 Apr 16;284(5413):455-61. doi: 10.1126/science.284.5413.455. Science. 1999. PMID: 10205047 Free article.
Mutation of the VHL tumor suppressor is associated with the inherited von Hippel-Lindau (VHL) cancer syndrome and the majority of kidney cancers. VHL binds the ElonginC-ElonginB complex and regulates levels of hypoxia-inducible proteins. ...
Mutation of the VHL tumor suppressor is associated with the inherited von Hippel-Lindau (VHL) cancer syndrome and the majority …
VHL regulates NEK1 via both HIF-2alpha pathway and ubiquitin-proteasome pathway in renal cancer cell.
Chen G, Zhou J, Chen J, Zhu J, Liu SC, Ding XF, Zhang Q. Chen G, et al. Biochem Biophys Res Commun. 2019 Feb 12;509(3):797-802. doi: 10.1016/j.bbrc.2019.01.001. Epub 2019 Jan 8. Biochem Biophys Res Commun. 2019. PMID: 30635121
Both Von Hippel-Lindau tumor suppressor (VHL) and Never-in-mitosis A (NIMA)-related kinase 1 (NEK1) are involved in primary cilium formation, but whether VHL could regulate NEK1 is unknown. ...VHL-overexpression down-regulated NEK1 in 769-P cells, while VH
Both Von Hippel-Lindau tumor suppressor (VHL) and Never-in-mitosis A (NIMA)-related kinase 1 (NEK1) are involved in primary cilium fo …
Von Hippel-Lindau disease (vHL). National clinical guideline for diagnosis and surveillance in Denmark. 3rd edition.
Binderup ML, Bisgaard ML, Harbud V, Møller HU, Gimsing S, Friis-Hansen L, Hansen Tv, Bagi P, Knigge U, Kosteljanetz M, Bøgeskov L, Thomsen C, Gerdes AM, Ousager LB, Sunde L; Danish vHL Coordination Group. Binderup ML, et al. Dan Med J. 2013 Dec;60(12):B4763. Dan Med J. 2013. PMID: 24355456 Free article.
The guideline has been composed by the Danish Coordination Group for vHL which is comprised of Danish doctors and specialists interested in vHL. ...To facilitate the coordination, and especially for the patients' own use, a mobile chart can be used. In 2012, the Dan …
The guideline has been composed by the Danish Coordination Group for vHL which is comprised of Danish doctors and specialists interes …
Ultrasound Microbubble-Mediated VHL Regulates the Biological Behavior of Ovarian Cancer Cells.
Li C, Hu S, Yue Y. Li C, et al. Ultrasound Med Biol. 2021 Mar;47(3):723-732. doi: 10.1016/j.ultrasmedbio.2020.11.001. Epub 2020 Nov 28. Ultrasound Med Biol. 2021. PMID: 33261909
The effect of microbubble-treated VHL was similar to liposome-mediated regulation, while ultrasound treatment enhanced the effect of VHL on OVCAR-3 cells. More interestingly, ultrasound microbubble-mediated VHL had the most obvious regulatory effect on OVCAR- …
The effect of microbubble-treated VHL was similar to liposome-mediated regulation, while ultrasound treatment enhanced the effect of …
A synonymous VHL variant in exon 2 confers susceptibility to familial pheochromocytoma and von Hippel-Lindau disease.
Flores SK, Cheng Z, Jasper AM, Natori K, Okamoto T, Tanabe A, Gotoh K, Shibata H, Sakurai A, Nakai T, Wang X, Zethoven M, Balachander S, Aita Y, Young W, Zheng S, Takekoshi K, Nakamura E, Tothill RW, Aguiar RCT, Dahia PLM. Flores SK, et al. J Clin Endocrinol Metab. 2019 Apr 4;104(9):3826-34. doi: 10.1210/jc.2019-00235. Online ahead of print. J Clin Endocrinol Metab. 2019. PMID: 30946460 Free PMC article.
However, the role of synonymous VHL variants in the disease is unclear. OBJECTIVE: We evaluated a synonymous VHL variant in patients with familial PHEO or VHL disease without a detectable pathogenic VHL mutation. ...CONCLUSION: A recurrent synonymous …
However, the role of synonymous VHL variants in the disease is unclear. OBJECTIVE: We evaluated a synonymous VHL variant in pa …
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