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Changing Management of Focal Cerebral Arteriopathy of Childhood From 2010 to 2022.
Fullerton HJ, Hills NK, Chen H, Dlamini N, Stence NV, Wintermark M; VIPS II Investigators. Fullerton HJ, et al. Stroke. 2025 Jun;56(6):1460-1468. doi: 10.1161/STROKEAHA.124.050550. Epub 2025 May 12. Stroke. 2025. PMID: 40351190
The median age was 11.3 years (56% male) in VIPS I and 11.4 years (55%) in VIPS II. Treatment with intravenous corticosteroids increased from 2 of 41 (5%) of FCA patients in VIPS I to 18 of 32 (56%) in VIPS II. ...CONCLUSIONS: Treatment of FCA with cor …
The median age was 11.3 years (56% male) in VIPS I and 11.4 years (55%) in VIPS II. Treatment with intravenous corticosteroids …
Evidence of Varicella Zoster Virus Reactivation in Children With Arterial Ischemic Stroke: Results of the VIPS II Study.
Fullerton HJ, Hills NK, Wintermark M, Dlamini N, Amlie-Lefond C, Dowling MM, Jordan LC, Friedman NR, Elkind MSV, Grose C; VIPS II Investigators* *. Fullerton HJ, et al. J Am Heart Assoc. 2025 Mar 18;14(6):e039184. doi: 10.1161/JAHA.124.039184. Epub 2025 Mar 18. J Am Heart Assoc. 2025. PMID: 40099546 Free PMC article.
BACKGROUND: Varicella zoster virus (VZV) has historically been associated with focal cerebral arteriopathy and arterial ischemic stroke (AIS) in children, and risk of AIS and myocardial infarction in adults. The VIPS (Vascular Effects of Infection in Pediatric Stroke) II s …
BACKGROUND: Varicella zoster virus (VZV) has historically been associated with focal cerebral arteriopathy and arterial ischemic stroke (AIS …
The vascular effects of infection in Pediatric Stroke (VIPS) Study.
Fullerton HJ, Elkind MS, Barkovich AJ, Glaser C, Glidden D, Hills NK, Leiva-Salinas C, Wintermark M, Deveber GA. Fullerton HJ, et al. J Child Neurol. 2011 Sep;26(9):1101-10. doi: 10.1177/0883073811408089. Epub 2011 May 25. J Child Neurol. 2011. PMID: 21616922 Free PMC article.
The multicenter Vascular Effects of Infection in Pediatric Stroke (VIPS) cohort study will test the hypotheses that (1) infection can lead to childhood arterial ischemic stroke by causing vascular injury and (2) resultant arteriopathy and inflammatory markers predict recur …
The multicenter Vascular Effects of Infection in Pediatric Stroke (VIPS) cohort study will test the hypotheses that (1) infection can …
The Role of Infection and Inflammation in the Pathogenesis of Pediatric Arterial Ischemic Stroke.
Cornet MC, Grose C, Vexler Z, Wu YW, Fullerton HJ. Cornet MC, et al. Among authors: fullerton hj. Semin Pediatr Neurol. 2022 Dec;44:100995. doi: 10.1016/j.spen.2022.100995. Epub 2022 Sep 10. Semin Pediatr Neurol. 2022. PMID: 36456035 Free PMC article. Review.
However, infections are common in childhood, while stroke is uncommon. The ongoing VIPS II (Vascular effects of Infection in Pediatric Stroke) study aims to identify the array of pathogens that may lead to childhood AIS and whether either unusual strains or unusual combina …
However, infections are common in childhood, while stroke is uncommon. The ongoing VIPS II (Vascular effects of Infection in Pediatri …
Infection in Childhood Arterial Ischemic Stroke: Metagenomic Next-Generation Sequencing Results of the VIPS II Study.
Karalius MC, Ramachandran PS, Wapniarski A, Wang M, Zia M, Hills NK, Wintermark M, Grose C, Dowling MM, Wilson JL, Lee S, Chung M, Barry M, Xu H, DeRisi JL, Wilson MR, Fullerton HJ; VIPS II Investigators. Karalius MC, et al. Among authors: fullerton hj. Stroke. 2025 Aug;56(8):2110-2121. doi: 10.1161/STROKEAHA.124.050548. Epub 2025 May 1. Stroke. 2025. PMID: 40308204
We leverage metagenomic next-generation sequencing (mNGS), a comprehensive microbial detection tool, to test the first hypothesis. METHODS: The VIPS II study (Vascular Effects of Infection in Pediatric Stroke II) prospectively enrolled children with AIS at 22 international …
We leverage metagenomic next-generation sequencing (mNGS), a comprehensive microbial detection tool, to test the first hypothesis. METHODS: …
Assessing the Impact of the COVID-19 Pandemic on Childhood Arterial Ischemic Stroke: An Unanticipated Natural Experiment.
Fullerton HJ, Hills NK, Wintermark M, Dlamini N, Fox CK, Cummings DD, Bernard TJ, Beslow LA, Sun LR, Grose C, Norris PJ, Di Germanio C; VIPS II Investigators. Fullerton HJ, et al. Stroke. 2025 May;56(5):1200-1209. doi: 10.1161/STROKEAHA.124.049909. Epub 2025 Apr 2. Stroke. 2025. PMID: 40171657 Free article.
BACKGROUND: The VIPS (Vascular Effects of Infection in Pediatric Stroke) II prospective cohort study aimed to better understand published findings that common acute infections, particularly respiratory viruses, can trigger childhood arterial ischemic stroke (AIS). ...
BACKGROUND: The VIPS (Vascular Effects of Infection in Pediatric Stroke) II prospective cohort study aimed to better understand publi …
Imaging Predictors of Neurologic Outcome After Pediatric Arterial Ischemic Stroke.
Jiang B, Hills NK, Forsyth R, Jordan LC, Slim M, Pavlakis SG, Freidman N, Dlamini N, Farooq O, Li Y, Zhu G, Fullerton H, Wintermark M, Lo WD; VIPS Investigators*. Jiang B, et al. Among authors: fullerton h. Stroke. 2021 Jan;52(1):152-161. doi: 10.1161/STROKEAHA.120.030965. Epub 2020 Dec 7. Stroke. 2021. PMID: 33280552 Free PMC article.
METHODS: We used prospectively collected demographic and clinical data, imaging data, and 1-year outcomes from the VIPS study (Vascular Effects of Infection in Pediatric Stroke). In 288 patients with first-time stroke, we measured infarct volume and location on the acute m …
METHODS: We used prospectively collected demographic and clinical data, imaging data, and 1-year outcomes from the VIPS study (Vascul …
Herpesvirus Infections and Childhood Arterial Ischemic Stroke: Results of the VIPS Study.
Elkind MS, Hills NK, Glaser CA, Lo WD, Amlie-Lefond C, Dlamini N, Kneen R, Hod EA, Wintermark M, deVeber GA, Fullerton HJ; VIPS Investigators*. Elkind MS, et al. Among authors: fullerton hj. Circulation. 2016 Feb 23;133(8):732-41. doi: 10.1161/CIRCULATIONAHA.115.018595. Epub 2016 Jan 26. Circulation. 2016. PMID: 26813104 Free PMC article.
Socioeconomic determinants of outcome after childhood arterial ischemic stroke.
Jordan LC, Hills NK, Fox CK, Ichord RN, Pergami P, deVeber GA, Fullerton HJ, Lo W; VIPS Investigators. Jordan LC, et al. Among authors: fullerton hj. Neurology. 2018 Aug 7;91(6):e509-e516. doi: 10.1212/WNL.0000000000005946. Epub 2018 Jul 6. Neurology. 2018. PMID: 29980641 Free PMC article.
METHODS: From 2010 to 2014, the Vascular effects of Infection in Pediatric Stroke (VIPS) observational study prospectively enrolled and confirmed 355 children (age 29 days-18 years) with AIS at 37 international centers. ...
METHODS: From 2010 to 2014, the Vascular effects of Infection in Pediatric Stroke (VIPS) observational study prospectively enrolled a …
18 results