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A method to predict functional residues in proteins.
Casari G, Sander C, Valencia A. Casari G, et al. Nat Struct Biol. 1995 Feb;2(2):171-8. doi: 10.1038/nsb0295-171. Nat Struct Biol. 1995. PMID: 7749921
The biological activity of a protein typically depends on the presence of a small number of functional residues. Identifying these residues from the amino acid sequences alone would be useful. ...Here, we present a novel method that exploits such patterns for …
The biological activity of a protein typically depends on the presence of a small number of functional residues. Identifying t …
An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins.
Bork P, Sander C, Valencia A. Bork P, et al. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7290-4. doi: 10.1073/pnas.89.16.7290. Proc Natl Acad Sci U S A. 1992. PMID: 1323828 Free PMC article.
Optimal superposition of the three structures and alignment of many sequences in each of the three families has revealed a set of common conserved residues, distributed in five sequence motifs, which are involved in ATP binding and in a putative interdomain hinge. . …
Optimal superposition of the three structures and alignment of many sequences in each of the three families has revealed a set of com …
A module of the DnaJ heat shock proteins found in malaria parasites.
Bork P, Sander C, Valencia A, Bukau B. Bork P, et al. Trends Biochem Sci. 1992 Apr;17(4):129. doi: 10.1016/0968-0004(92)90319-5. Trends Biochem Sci. 1992. PMID: 1585456 No abstract available.
The ras protein family: evolutionary tree and role of conserved amino acids.
Valencia A, Chardin P, Wittinghofer A, Sander C. Valencia A, et al. Biochemistry. 1991 May 14;30(19):4637-48. doi: 10.1021/bi00233a001. Biochemistry. 1991. PMID: 2029511 Review. No abstract available.
GTPase domains of ras p21 oncogene protein and elongation factor Tu: analysis of three-dimensional structures, sequence families, and functional sites.
Valencia A, Kjeldgaard M, Pai EF, Sander C. Valencia A, et al. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5443-7. doi: 10.1073/pnas.88.12.5443. Proc Natl Acad Sci U S A. 1991. PMID: 2052624 Free PMC article.
(i) A structure-based alignment of p21 and elongation factor Tu. (ii) The definition of a common conserved structural core that may be useful as the basis of model building by homology of the three-dimensional structure of any GTPase domain. ...These regions are can …
(i) A structure-based alignment of p21 and elongation factor Tu. (ii) The definition of a common conserved structural core tha …
A conserved loop in the ATPase domain of the DnaK chaperone is essential for stable binding of GrpE.
Buchberger A, Schröder H, Büttner M, Valencia A, Bukau B. Buchberger A, et al. Nat Struct Biol. 1994 Feb;1(2):95-101. doi: 10.1038/nsb0294-95. Nat Struct Biol. 1994. PMID: 7656024
Analysis of the mutant DnaK756 protein, which has a lower affinity for GrpE, reveals a role for residue Gly 32 in GrpE binding. ...Conservation of this loop within the Hsp70 family suggests that cooperation between Hsp70 and GrpE-like proteins may be a genera …
Analysis of the mutant DnaK756 protein, which has a lower affinity for GrpE, reveals a role for residue Gly 32 in GrpE binding …
Cloning and subcellular localization of novel rab proteins reveals polarized and cell type-specific expression.
Lütcke A, Parton RG, Murphy C, Olkkonen VM, Dupree P, Valencia A, Simons K, Zerial M. Lütcke A, et al. J Cell Sci. 1994 Dec;107 ( Pt 12):3437-48. J Cell Sci. 1994. PMID: 7706395
Using a PCR-based cloning approach we have recently identified several novel rab proteins, extending the total number of this family to more than 30 members. ...Both northern blot analysis and confocal immunofluorescence microscopy demonstrated that these proteins are expr …
Using a PCR-based cloning approach we have recently identified several novel rab proteins, extending the total number of this family …
Nucleotide sequence and analysis of the centromeric region of yeast chromosome IX.
Voss H, Tamames J, Teodoru C, Valencia A, Sensen C, Wiemann S, Schwager C, Zimmermann J, Sander C, Ansorge W. Voss H, et al. Yeast. 1995 Jan;11(1):61-78. doi: 10.1002/yea.320110109. Yeast. 1995. PMID: 7762303
We have determined the nucleotide sequence of a cosmid (pIX338) containing the centromere region of yeast (Saccharomyces cerevisiae) chromosome IX. ...These include a mammalian tyrosine kinase substrate; the Escherichia coli cell cycle protein MinD; the human inosit …
We have determined the nucleotide sequence of a cosmid (pIX338) containing the centromere region of yeast (Saccharomyces cerevisiae) …
The chaperone function of DnaK requires the coupling of ATPase activity with substrate binding through residue E171.
Buchberger A, Valencia A, McMacken R, Sander C, Bukau B. Buchberger A, et al. EMBO J. 1994 Apr 1;13(7):1687-95. EMBO J. 1994. PMID: 7908876 Free PMC article.
This coupling is proposed to require a glutamate residue, E175 of bovine Hsc70, that is entirely conserved within the Hsp70 family, as it contacts bound Mg2+/ATP and is part of a hinge required for a postulated ATP-dependent opening/closing movement of the nu …
This coupling is proposed to require a glutamate residue, E175 of bovine Hsc70, that is entirely conserved within the Hsp70 family, a …
Correlated mutations and residue contacts in proteins.
Göbel U, Sander C, Schneider R, Valencia A. Göbel U, et al. Proteins. 1994 Apr;18(4):309-17. doi: 10.1002/prot.340180402. Proteins. 1994. PMID: 8208723
This fact can be exploited to interpret correlated mutations observed in a sequence family as an indication of probable physical contact in three dimensions. Here we present a simple and general method to analyze correlations in mutational behavior between different …
This fact can be exploited to interpret correlated mutations observed in a sequence family as an indication of probable physical cont …
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