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The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo.
DeChiara TM, Bowen DC, Valenzuela DM, Simmons MV, Poueymirou WT, Thomas S, Kinetz E, Compton DL, Rojas E, Park JS, Smith C, DiStefano PS, Glass DJ, Burden SJ, Yancopoulos GD. DeChiara TM, et al. Among authors: valenzuela dm. Cell. 1996 May 17;85(4):501-12. doi: 10.1016/s0092-8674(00)81251-9. Cell. 1996. PMID: 8653786 Free article.
Agrin acts via a MuSK receptor complex.
Glass DJ, Bowen DC, Stitt TN, Radziejewski C, Bruno J, Ryan TE, Gies DR, Shah S, Mattsson K, Burden SJ, DiStefano PS, Valenzuela DM, DeChiara TM, Yancopoulos GD. Glass DJ, et al. Among authors: valenzuela dm. Cell. 1996 May 17;85(4):513-23. doi: 10.1016/s0092-8674(00)81252-0. Cell. 1996. PMID: 8653787 Free article.
The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome.
Raz R, Stricker S, Gazzerro E, Clor JL, Witte F, Nistala H, Zabski S, Pereira RC, Stadmeyer L, Wang X, Gowen L, Sleeman MW, Yancopoulos GD, Canalis E, Mundlos S, Valenzuela DM, Economides AN. Raz R, et al. Among authors: valenzuela dm. Development. 2008 May;135(9):1713-23. doi: 10.1242/dev.015149. Epub 2008 Mar 19. Development. 2008. PMID: 18353862
Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations.
Deng K, Pertea M, Rongvaux A, Wang L, Durand CM, Ghiaur G, Lai J, McHugh HL, Hao H, Zhang H, Margolick JB, Gurer C, Murphy AJ, Valenzuela DM, Yancopoulos GD, Deeks SG, Strowig T, Kumar P, Siliciano JD, Salzberg SL, Flavell RA, Shan L, Siliciano RF. Deng K, et al. Among authors: valenzuela dm. Nature. 2015 Jan 15;517(7534):381-5. doi: 10.1038/nature14053. Epub 2015 Jan 7. Nature. 2015. PMID: 25561180 Free PMC article.
High-throughput engineering of the mouse genome coupled with high-resolution expression analysis.
Valenzuela DM, Murphy AJ, Frendewey D, Gale NW, Economides AN, Auerbach W, Poueymirou WT, Adams NC, Rojas J, Yasenchak J, Chernomorsky R, Boucher M, Elsasser AL, Esau L, Zheng J, Griffiths JA, Wang X, Su H, Xue Y, Dominguez MG, Noguera I, Torres R, Macdonald LE, Stewart AF, DeChiara TM, Yancopoulos GD. Valenzuela DM, et al. Nat Biotechnol. 2003 Jun;21(6):652-9. doi: 10.1038/nbt822. Epub 2003 May 5. Nat Biotechnol. 2003. PMID: 12730667
128 results