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Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis.
Matus S, Lopez E, Valenzuela V, Nassif M, Hetz C. Matus S, et al. Among authors: valenzuela v. PLoS One. 2013 Jul 18;8(7):e66672. doi: 10.1371/journal.pone.0066672. Print 2013. PLoS One. 2013. PMID: 23874395 Free PMC article.
Unraveling the role of motoneuron autophagy in ALS.
Valenzuela V, Nassif M, Hetz C. Valenzuela V, et al. Autophagy. 2018;14(4):733-737. doi: 10.1080/15548627.2018.1432327. Epub 2018 Mar 13. Autophagy. 2018. PMID: 29388464 Free PMC article. Review.
Proteostasis disturbance in amyotrophic lateral sclerosis.
Medinas DB, Valenzuela V, Hetz C. Medinas DB, et al. Among authors: valenzuela v. Hum Mol Genet. 2017 Oct 1;26(R2):R91-R104. doi: 10.1093/hmg/ddx274. Hum Mol Genet. 2017. PMID: 28977445 Review.
Injury to the nervous system: A look into the ER.
Valenzuela V, Oñate M, Hetz C, Court FA. Valenzuela V, et al. Brain Res. 2016 Oct 1;1648(Pt B):617-625. doi: 10.1016/j.brainres.2016.04.053. Epub 2016 Apr 23. Brain Res. 2016. PMID: 27117870 Review.
ALS-linked protein disulfide isomerase variants cause motor dysfunction.
Woehlbier U, Colombo A, Saaranen MJ, Pérez V, Ojeda J, Bustos FJ, Andreu CI, Torres M, Valenzuela V, Medinas DB, Rozas P, Vidal RL, Lopez-Gonzalez R, Salameh J, Fernandez-Collemann S, Muñoz N, Matus S, Armisen R, Sagredo A, Palma K, Irrazabal T, Almeida S, Gonzalez-Perez P, Campero M, Gao FB, Henny P, van Zundert B, Ruddock LW, Concha ML, Henriquez JP, Brown RH, Hetz C. Woehlbier U, et al. Among authors: valenzuela v. EMBO J. 2016 Apr 15;35(8):845-65. doi: 10.15252/embj.201592224. Epub 2016 Feb 11. EMBO J. 2016. PMID: 26869642 Free PMC article.
Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis.
Nassif M, Valenzuela V, Rojas-Rivera D, Vidal R, Matus S, Castillo K, Fuentealba Y, Kroemer G, Levine B, Hetz C. Nassif M, et al. Among authors: valenzuela v. Autophagy. 2014 Jul;10(7):1256-71. doi: 10.4161/auto.28784. Epub 2014 May 12. Autophagy. 2014. PMID: 24905722 Free PMC article.
ER Dysfunction and Protein Folding Stress in ALS.
Matus S, Valenzuela V, Medinas DB, Hetz C. Matus S, et al. Among authors: valenzuela v. Int J Cell Biol. 2013;2013:674751. doi: 10.1155/2013/674751. Epub 2013 Nov 13. Int J Cell Biol. 2013. PMID: 24324498 Free PMC article. Review.
Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons.
Castillo K, Nassif M, Valenzuela V, Rojas F, Matus S, Mercado G, Court FA, van Zundert B, Hetz C. Castillo K, et al. Among authors: valenzuela v. Autophagy. 2013 Sep;9(9):1308-20. doi: 10.4161/auto.25188. Epub 2013 Jun 6. Autophagy. 2013. PMID: 23851366
Activation of the unfolded protein response enhances motor recovery after spinal cord injury.
Valenzuela V, Collyer E, Armentano D, Parsons GB, Court FA, Hetz C. Valenzuela V, et al. Cell Death Dis. 2012 Feb 16;3(2):e272. doi: 10.1038/cddis.2012.8. Cell Death Dis. 2012. PMID: 22337234 Free PMC article.
Gene therapy to target ER stress in brain diseases.
Valenzuela V, Martínez G, Duran-Aniotz C, Hetz C. Valenzuela V, et al. Brain Res. 2016 Oct 1;1648(Pt B):561-570. doi: 10.1016/j.brainres.2016.04.064. Epub 2016 Apr 27. Brain Res. 2016. PMID: 27131987 Review.
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