Van Der Poll, Tom[Author] OR Wiersinga WJ[Author] OR Scicluna BP[Author] OR De Vos AF[Author] OR Holleman, Frits[Author] OR Nanayakkara PW[Author] OR van 't Veer C - Search Results

Year	Number of Results
1988	2
1990	2
1992	1
1993	2
1994	6
1995	5
1996	8
1997	8
1998	8
1999	10
2000	7
2001	14
2002	26
2003	39
2004	37
2005	38
2006	44
2007	43
2008	58
2009	59
2010	50
2011	52
2012	54
2013	59
2014	58
2015	70
2016	78
2017	77
2018	64
2019	67
2020	70
2021	99
2022	94
2023	56
2024	64
2025	55

1

Role of Myeloid Cell Glucose Transporter 1 in the Host Response During Pneumonia Caused by Streptococcus pneumoniae.

Pereverzeva L, Léopold V, Saris A, Schuurman AR, Butler JM, Reijnders TDY, Roelofs JJTH, Faber DR, Wiersinga WJ, Van't Veer C, de Vos AF, van der Poll T. Pereverzeva L, et al. Among authors: wiersinga wj, van t veer c, van der poll t, de vos af. Int J Mol Sci. 2025 Oct 28;26(21):10461. doi: 10.3390/ijms262110461. Int J Mol Sci. 2025. PMID: 41226500 Free PMC article.

2

National Early Warning Score for Predicting Clinical Outcome of Acute Pulmonary Embolism in Intermediate-High Risk Patients.

Overgaauw AJC, Nossent EJ, Meijboom LJ, Serne EH, Smulders YM, Nanayakkara PWB, Bogaard HJ, Tuinman PR, Klok EA. Overgaauw AJC, et al. Among authors: nanayakkara pwb. TH Open. 2025 Nov 4;9:a27199061. doi: 10.1055/a-2719-9061. eCollection 2025. TH Open. 2025. PMID: 41215788 Free PMC article.

3

Predicting Urine Culture Outcomes in Adult Patients Using Machine Learning with the Aim of Reducing Unnecessary Urine Cultures.

Boerman AW, van Ingen MM, Schotman HHM, Visser A, Janes VA, Nanayakkara PWB, Schut MC, de Jonge R. Boerman AW, et al. Among authors: nanayakkara pwb. J Appl Lab Med. 2025 Nov 4;10(6):1439-1452. doi: 10.1093/jalm/jfaf131. J Appl Lab Med. 2025. PMID: 41189111

4

On the future of guidelines.

Wiersinga WJ, Møller MH, de Waele JJ, Prescott HC. Wiersinga WJ, et al. Crit Care. 2025 Nov 1;29(1):465. doi: 10.1186/s13054-025-05731-x. Crit Care. 2025. PMID: 41176597 Free PMC article. No abstract available.

5

Gut microbiota predicts the risk of future COVID-19 hospitalization and mortality: insights from the population-based HELIUS Study.

Kullberg RFJ, Appelman B, Galenkamp H, Prins M, van den Born BJ, Nieuwdorp M, Haak BW, Wiersinga WJ. Kullberg RFJ, et al. Among authors: wiersinga wj. J Infect Dis. 2025 Oct 31:jiaf541. doi: 10.1093/infdis/jiaf541. Online ahead of print. J Infect Dis. 2025. PMID: 41169175

6

The proteomic landscape of blood monocytes in community-acquired pneumonia.

Chouchane O, Michels EHA, Leite GGF, de Vos AF, de Brabander J, Butler JM, Brands X, Haak BW, Klarenbeek AM, Wiersinga WJ, Scicluna BP, van 't Veer C, Kaas KF, Petrosius V, Schoof EM, van der Poll T. Chouchane O, et al. Among authors: scicluna bp, wiersinga wj, van t veer c, van der poll t, de vos af. Eur Respir J. 2025 Oct 28:2500335. doi: 10.1183/13993003.00335-2025. Online ahead of print. Eur Respir J. 2025. PMID: 41151990 Free article.

7

Author Correction: A consensus immune dysregulation framework for sepsis and critical illnesses.

Moore AR, Zheng H, Ganesan A, Hasin-Brumshtein Y, Maddali MV, Levitt JE, van der Poll T, Lu J, Bouma HR, Scicluna BP, Giamarellos-Bourboulis EJ, Kotsaki A, Martin-Loeches I, Garduno A, Hinson J, Rothman RE, Sevransky J, Wright DW, Atreya MR, Moldawer LL, Efron PA, Kralovcova M, Karvunidis T, Giannini HM, Meyer NJ, Sweeney TE, Rogers AJ, Khatri P. Moore AR, et al. Among authors: scicluna bp, van der poll t. Nat Med. 2025 Oct 27. doi: 10.1038/s41591-025-04066-y. Online ahead of print. Nat Med. 2025. PMID: 41145793 No abstract available.

8

Reply to Feng et al.: Potential Pitfalls in Proteomic Risk Assessment for Community-acquired Pneumonia.

Michels EHA, Peters-Sengers H, van der Poll T. Michels EHA, et al. Among authors: van der poll t. Am J Respir Crit Care Med. 2025 Oct 22. doi: 10.1164/rccm.202508-1873LE. Online ahead of print. Am J Respir Crit Care Med. 2025. PMID: 41123887 No abstract available.

9

Reply: Colonisation versus infection in ICU-acquired pneumonia.

de Brabander J, van der Poll T. de Brabander J, et al. Among authors: van der poll t. Eur Respir J. 2025 Oct 16;66(4):2501700. doi: 10.1183/13993003.01700-2025. Print 2025 Oct. Eur Respir J. 2025. PMID: 41101940 No abstract available.

10

The Sirt1 Activator SRT1720 Mitigates Human Monocyte Activation and Improves Outcome During Gram-Negative Pneumosepsis in Mice.

Blot M, Léopold V, de Beer R, Florquin S, Butler JM, Van't Veer C, de Vos AF, van der Poll T. Blot M, et al. Among authors: van t veer c, van der poll t, de vos af. Int J Mol Sci. 2025 Sep 24;26(19):9309. doi: 10.3390/ijms26199309. Int J Mol Sci. 2025. PMID: 41096578 Free PMC article.

11

A consensus immune dysregulation framework for sepsis and critical illnesses.

Moore AR, Zheng H, Ganesan A, Hasin-Brumshtein Y, Maddali MV, Levitt JE, van der Poll T, Lu J, Bouma HR, Scicluna BP, Giamarellos-Bourboulis EJ, Kotsaki A, Martin-Loeches I, Garduno A, Hinson J, Rothman RE, Sevransky J, Wright DW, Atreya MR, Moldawer LL, Efron PA, Kralovcova M, Karvunidis T, Giannini HM, Meyer NJ, Sweeney TE, Rogers AJ, Khatri P. Moore AR, et al. Among authors: scicluna bp, van der poll t. Nat Med. 2025 Sep 30. doi: 10.1038/s41591-025-03956-5. Online ahead of print. Nat Med. 2025. PMID: 41028543

12

A consensus blood transcriptomic framework for sepsis.

Scicluna BP, Cano-Gamez K, Burnham KL, Davenport EE, Moore AR, Khan S, Hinds CJ, Cremer OL, Khatri P, Sweeney TE, Knight JC, van der Poll T. Scicluna BP, et al. Among authors: van der poll t. Nat Med. 2025 Sep 30. doi: 10.1038/s41591-025-03964-5. Online ahead of print. Nat Med. 2025. PMID: 41028542

13

Effect of the gut microbiota-derived tryptophan metabolite indole-3-acetic acid in pneumonia.

Kullberg RFJ, van Linge CCA, Haak BW, Paul PS, Butler JM, Wolff N, van Engelen TSR, Sikkens JJ, Bomers MK, Lefèvre A, Cremer OL, Roelofs JJTH, Sovran B, van den Wijngaard R, de Vos AF, de Jonge WJ, van der Poll T, Wiersinga WJ. Kullberg RFJ, et al. Among authors: wiersinga wj, van der poll t, de vos af. Nat Commun. 2025 Sep 29;16(1):8565. doi: 10.1038/s41467-025-63611-y. Nat Commun. 2025. PMID: 41022731 Free PMC article.

14

Detection of Burkholderia thailandensis in Soil Samples, Suriname.

Savelkoel J, Zimmermann R, Tjon ANC, Dzebisasjvili T, Lanzl M, Matamoros S, Mawie T, Woittiez L, Vreden S, Birnie E, Wiersinga WJ. Savelkoel J, et al. Among authors: wiersinga wj. Emerg Infect Dis. 2025 Oct;31(10):2057-2059. doi: 10.3201/eid3110.251114. Emerg Infect Dis. 2025. PMID: 41017061 Free PMC article.

15

The immunology of sepsis: translating new insights into clinical practice.

Kox M, Bauer M, Bos LDJ, Bouma H, Calandra T, Calfee CS, Chousterman BG, Derde LPG, Giamarellos-Bourboulis EJ, Gómez H, Netea MG, Ostermann M, van der Poll T, Scicluna BP, Seymour C, Shankar-Hari M, Shapiro N, Singer M, Venet F, Vlaar APJ, van Vught LA, Weis S, Joost Wiersinga W, Pickkers P. Kox M, et al. Among authors: scicluna bp, van der poll t. Nat Rev Nephrol. 2025 Sep 24. doi: 10.1038/s41581-025-01004-6. Online ahead of print. Nat Rev Nephrol. 2025. PMID: 40993251 Review.

16

Seasonal Coronavirus-Induced Immunological Imprinting and Previous Herpesvirus Infections in Patients With Long COVID.

Mak WA, Wapperom D, Redel AL, Koeleman JGM, Smit PW, Lam-Tse WK, van der Poll T, Chen HJ, den Dunnen J, Braunstahl GJ, Ong DSY. Mak WA, et al. Among authors: van der poll t. J Med Virol. 2025 Sep;97(9):e70582. doi: 10.1002/jmv.70582. J Med Virol. 2025. PMID: 40884088 Free PMC article.

17

Re: Breast implant illness after reconstruction with silicone breast implants-the fallacy of absence.

Azahaf S, Nanayakkara PWB. Azahaf S, et al. Among authors: nanayakkara pwb. J Natl Cancer Inst. 2025 Nov 1;117(11):2405-2406. doi: 10.1093/jnci/djaf245. J Natl Cancer Inst. 2025. PMID: 40875499 No abstract available.

18

A phase I trial evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenously administered low-anticoagulant heparin (M6229) in critically ill sepsis patients.

van Mourik N, van Amstel RBE, Slim MA, van Vught LA, van der Poll T, Huckriede J, de Vries F, de Kimpe SJ, Crabbé R, van Leeuwen SJM, Ekhart PF, Reutelingsperger CPM, Nicolaes GAF, Vlaar APJ, Müller MCA. van Mourik N, et al. Among authors: van der poll t. Intensive Care Med Exp. 2025 Aug 18;13(1):84. doi: 10.1186/s40635-025-00790-4. Intensive Care Med Exp. 2025. PMID: 40824474 Free PMC article.

19

Transforming acute care: a scoping review on the effectiveness, safety and implementation challenges of Hospital-at-Home models.

Sultani K, Smeulers M, de Vries R, Zonderhuis BM, Nanayakkara PWB. Sultani K, et al. Among authors: nanayakkara pwb. BMJ Open. 2025 Aug 8;15(8):e098411. doi: 10.1136/bmjopen-2024-098411. BMJ Open. 2025. PMID: 40780723 Free PMC article.

20

Butyrate-producing gut bacterium Faecalibacterium prausnitzii protects against bacterial pneumonia.

Kullberg RFJ, van Linge CCA, de Vos AF, Brands X, Bui TPN, Butler JM, Faber DR, Verhoeven A, van den Wijngaard RM, de Jonge WJ, Nieuwdorp M, van der Poll T, Haak BW, Wiersinga WJ. Kullberg RFJ, et al. Among authors: wiersinga wj, van der poll t, de vos af. Eur Respir J. 2025 Nov 6;66(5):2402208. doi: 10.1183/13993003.02208-2024. Print 2025 Nov. Eur Respir J. 2025. PMID: 40774806 Free PMC article.

21

Omics in Pneumonia: A Necessary Path Towards Personalized Medicine.

Joosten SCM, van der Poll T. Joosten SCM, et al. Among authors: van der poll t. Arch Bronconeumol. 2025 Jul 22:S0300-2896(25)00259-5. doi: 10.1016/j.arbres.2025.07.009. Online ahead of print. Arch Bronconeumol. 2025. PMID: 40750521 English, Spanish. No abstract available.

22

Towards novel BIOmarkers to diagnose SEPsis (BIOSEP) in the emergency room: a protocol for a multicentre, prospective cohort study.

Reijnders E, Turgman O, Joosten SCM, Schinkel M, Slim MA, Douma RA, Moeniralam HS, Peters-Sengers H, van der Poll T, Wiersinga WJ. Reijnders E, et al. Among authors: wiersinga wj, van der poll t. BMJ Open. 2025 Aug 1;15(7):e103138. doi: 10.1136/bmjopen-2025-103138. BMJ Open. 2025. PMID: 40750284 Free PMC article.

23

Beyond Lip Service: A Position Paper to Truly Stimulate Shared Decision-Making.

Thodé M, Dikken J, Nanayakkara PWB. Thodé M, et al. Among authors: nanayakkara pwb. J Adv Nurs. 2025 Jul 22. doi: 10.1111/jan.70053. Online ahead of print. J Adv Nurs. 2025. PMID: 40696827

24

Letter to the Editor regarding "blood culture bottle shortage mitigation efforts: analysis of impact on ordering and patient impact" by Doern et al.

van der Zaag AY, den Hollander AG, Bhagirath SC, Nanayakkara PWB. van der Zaag AY, et al. Among authors: nanayakkara pwb. Antimicrob Steward Healthc Epidemiol. 2025 Jul 11;5(1):e153. doi: 10.1017/ash.2025.10053. eCollection 2025. Antimicrob Steward Healthc Epidemiol. 2025. PMID: 40657034 Free PMC article. No abstract available.

25

Biological drivers of the host response in sepsis.

Wiersinga WJ, van der Poll T. Wiersinga WJ, et al. Among authors: van der poll t. Thorax. 2025 Jul 2:thorax-2024-222012. doi: 10.1136/thorax-2024-222012. Online ahead of print. Thorax. 2025. PMID: 40603006 Review.

26

The Plasma Proteome in Community-acquired Pneumonia: Pathophysiology, Outcome, and 10-Year Risk.

Michels EHA, Peters-Sengers H, de Brabander J, Schuurman AR, Reijnders TDY, Haak BW, Brands X, Joosten SCM, Faber DR, Cremer OL, Douma RA, de Vos AF, Wiersinga WJ, Butler JM, van der Poll T. Michels EHA, et al. Among authors: wiersinga wj, van der poll t, de vos af. Am J Respir Crit Care Med. 2025 Nov;211(11):2180-2190. doi: 10.1164/rccm.202502-0325OC. Am J Respir Crit Care Med. 2025. PMID: 40600965

27

Differential platelet protein release profiles in community-acquired pneumonia and COVID-19.

Chouchane O, Léopold V, Michels EHA, de Brabander J, van Linge CCA, Klarenbeek AM, Wiersinga WJ, van 't Veer C, van der Poll T. Chouchane O, et al. Among authors: wiersinga wj, van t veer c, van der poll t. ERJ Open Res. 2025 Jun 23;11(3):00863-2024. doi: 10.1183/23120541.00863-2024. eCollection 2025 May. ERJ Open Res. 2025. PMID: 40551807 Free PMC article.

28

Uncovering metabolic pathways in human alveolar macrophages in response to lipopolysaccharide.

van Linge CCA, Michels EHA, Pereverzeva L, de Beer R, Klarenbeek AM, Schomakers BV, van Weeghel M, Houtkooper RH, Wiersinga WJ, Bonta PI, Annema JT, van der Poll T, de Vos AF. van Linge CCA, et al. Among authors: wiersinga wj, van der poll t, de vos af. Clin Exp Immunol. 2025 Jan 21;219(1):uxaf028. doi: 10.1093/cei/uxaf028. Clin Exp Immunol. 2025. PMID: 40515396 Free PMC article.

29

Pathogen-specific host response in critically ill patients with blood stream infections: a nested case-control study.

Butler JM, Peters-Sengers H, Reijnders TDY, van Engelen TSR, Uhel F, van Vught LA, Schultz MJ, Laterre PF, François B, Sánchez-García M, Lombardo E, Sweeney TE, Bonten MJ, Wiersinga WJ, Sampson D, Bolero LC, Yager T, Cremer OL, Scicluna BP, van der Poll T. Butler JM, et al. Among authors: scicluna bp, wiersinga wj, van der poll t. EBioMedicine. 2025 Jul;117:105799. doi: 10.1016/j.ebiom.2025.105799. Epub 2025 Jun 11. EBioMedicine. 2025. PMID: 40505417 Free PMC article.

30

Sepsis in patients who are immunocompromised: diagnostic challenges and future therapies.

Deinhardt-Emmer S, Chousterman BG, Schefold JC, Flohé SB, Skirecki T, Kox M, Winkler MS, Cossarizza A, Wiersinga WJ, van der Poll T, Weigand MA, Cajander S, Giamarellos-Bourboulis EJ, Lachmann G, Girardis M, Scicluna BP, Ferrer R, Payen D, Weis S, Torres A, Bermejo-Martín JF, Osuchowski MF, Rubio I, Bouma HR. Deinhardt-Emmer S, et al. Among authors: scicluna bp, wiersinga wj, van der poll t. Lancet Respir Med. 2025 Jul;13(7):623-637. doi: 10.1016/S2213-2600(25)00124-9. Epub 2025 May 20. Lancet Respir Med. 2025. PMID: 40409328 Review.

31

Plasma H3.1 nucleosomes as biomarkers of infection, inflammation and organ failure.

Filippini DFL, Jiang M, Kramer L, van der Poll T, Cremer O, Hla TTW, Retter A, Bos LDJ; MARS consortium. Filippini DFL, et al. Among authors: van der poll t. Crit Care. 2025 May 19;29(1):198. doi: 10.1186/s13054-025-05415-6. Crit Care. 2025. PMID: 40390092 Free PMC article.

32

The effects of sleep improving interventions in medical hospital wards: the WEsleep study - A randomized clinical trial.

de Gans CJ, Meewisse AJG, van den Ende ES, van Zuylen ML, Nanayakkara PWB, Hermanides J, Stenvers DJ; WE Sleep Study Group. de Gans CJ, et al. Among authors: nanayakkara pwb. Eur J Intern Med. 2025 Sep;139:106308. doi: 10.1016/j.ejim.2025.04.015. Epub 2025 May 9. Eur J Intern Med. 2025. PMID: 40348656 Free article. Clinical Trial.

33

mTOR inhibition impacts the flagellin-augmented inflammatory and antimicrobial response of human airway epithelial cells to Pseudomonas aeruginosa.

van Linge CCA, Hulme KD, Peters-Sengers H, Kullberg RFJ, de Jong MD, Russell CA, de Vos AF, van der Poll T. van Linge CCA, et al. Among authors: van der poll t, de vos af. PLoS One. 2025 May 8;20(5):e0321462. doi: 10.1371/journal.pone.0321462. eCollection 2025. PLoS One. 2025. PMID: 40338861 Free PMC article.

34

Role of Liver Kinase 1B in Platelet Activation and Host Defense During Klebsiella pneumoniae-Induced Pneumosepsis.

Chouchane O, Léopold V, van Linge CCA, de Vos AF, Roelofs JJTH, van 't Veer C, van der Poll T. Chouchane O, et al. Among authors: van t veer c, van der poll t, de vos af. Int J Mol Sci. 2025 Apr 14;26(8):3714. doi: 10.3390/ijms26083714. Int J Mol Sci. 2025. PMID: 40332331 Free PMC article.

35

Modified Early Warning Score scores in the emergency department: Factors associated with changing scores to evaluate clinical improvement or deterioration.

Veldhuis LI, Visser MA, Verweij LM, Nanayakkara PWB, Ludikhuize J. Veldhuis LI, et al. Among authors: nanayakkara pwb. Int J Crit Illn Inj Sci. 2025 Jan-Mar;15(1):16-20. doi: 10.4103/ijciis.ijciis_43_24. Epub 2025 Mar 25. Int J Crit Illn Inj Sci. 2025. PMID: 40291551 Free PMC article.

36

Cost-effectiveness Analysis of Nirmatrelvir/Ritonavir for COVID-19 Among Individuals at High Risk: A Modeling Study.

Birnie E, Vergouwe M, Appelman B, Biemond JJ, Heijmans J, Nichols BE, Wiersinga WJ, Popping S; TURN-COVID studygroup. Birnie E, et al. Among authors: wiersinga wj. Open Forum Infect Dis. 2025 Mar 26;12(4):ofaf187. doi: 10.1093/ofid/ofaf187. eCollection 2025 Apr. Open Forum Infect Dis. 2025. PMID: 40256045 Free PMC article.

37

Correction: Pulmonary herpes simplex virus and cytomegalovirus in patients with acute respiratory distress syndrome related to COVID-19.

Boers LS, van Someren Gréve F, van Hattem JM, de Brabander J, Zwaan T, van Willigen H, Cornelissen M, de Jong M, van der Poll T, Duitman J, Schinkel J, Bos LDJ; and the OPPORTUNE consortium, the Amsterdam UMC COVID study group, the ArtDECO consortium. Boers LS, et al. Among authors: van der poll t. Intensive Care Med. 2025 May;51(5):1000-1002. doi: 10.1007/s00134-025-07854-9. Intensive Care Med. 2025. PMID: 40227322 Free PMC article. No abstract available.

38

Letter to the Editor Regarding The Streetlight Effect in BII Research.

Azahaf S, Nanayakkara PWB. Azahaf S, et al. Among authors: nanayakkara pwb. J Plast Reconstr Aesthet Surg. 2025 May;104:349-350. doi: 10.1016/j.bjps.2025.03.046. Epub 2025 Mar 22. J Plast Reconstr Aesthet Surg. 2025. PMID: 40164055 No abstract available.

39

Host Response Protein Biomarkers Indicative of Persistent Acute Kidney Injury in Critically Ill COVID-19 Patients.

Steenvoorden TS, de Kruijf KC, Appelman B, Moggre B, Bos LDJ, Vlaar APJ, Douma RA, Uhel F, Kers J, Oppelaar JJ, van Vught LA, Beudel M, Elbers PWG, Wiersinga WJ, van der Poll T, Vogt L, Peters-Sengers H; Amsterdam UMC COVID-19 Biobank Study Group and the CovidPredict Study Group. Steenvoorden TS, et al. Among authors: wiersinga wj, van der poll t. Crit Care Explor. 2025 Mar 13;7(3):e1222. doi: 10.1097/CCE.0000000000001222. eCollection 2025 Mar 1. Crit Care Explor. 2025. PMID: 40079888 Free PMC article.

40

Exploring Heterogeneity of Fecal Microbiome in Long COVID Patients at 3 to 6 Months After Infection.

Blankestijn JM, Baalbaki N, Beijers RJHCG, Cornelissen MEB, Wiersinga WJ, Abdel-Aziz MI, Maitland-van der Zee AH; P4O2 Consortium. Blankestijn JM, et al. Among authors: wiersinga wj. Int J Mol Sci. 2025 Feb 19;26(4):1781. doi: 10.3390/ijms26041781. Int J Mol Sci. 2025. PMID: 40004244 Free PMC article.

41

Comparison Between Signal Transduction Pathway Activity in Blood Cells of Sepsis Patients and Laboratory Models.

Bouwman W, Raymakers R, van der Poll T, van de Stolpe A. Bouwman W, et al. Among authors: van der poll t. Cells. 2025 Feb 19;14(4):311. doi: 10.3390/cells14040311. Cells. 2025. PMID: 39996782 Free PMC article.

42

Accuracy of self-reported disease severity and need for hospital admission.

Veldhuis LI, Kuit M, Nanayakkara PWB. Veldhuis LI, et al. Among authors: nanayakkara pwb. Emerg Med J. 2025 Jun 19;42(7):471-472. doi: 10.1136/emermed-2024-214408. Emerg Med J. 2025. PMID: 39988356 Free PMC article. No abstract available.

43

A Longitudinal Description of the Health-Related Quality of Life Among Individuals at High Risk After SARS-CoV-2 Infection: A Dutch Multicenter Observational Cohort Study.

Vergouwe M, Birnie E, van Veelen S, Biemond JJ, Appelman B, Peters-Sengers H, de Bree GJ, Popping S, Wiersinga WJ; TURN-COVID Study Group. Vergouwe M, et al. Among authors: wiersinga wj. Open Forum Infect Dis. 2025 Jan 30;12(2):ofaf055. doi: 10.1093/ofid/ofaf055. eCollection 2025 Feb. Open Forum Infect Dis. 2025. PMID: 39974282 Free PMC article.

44

Reply to: Should we be careful with exercise in post-exertional malaise after Long COVID?

Appelman B, Charlton BT, Goulding RP, Kerkhoff TJ, Breedveld EA, Noort W, Offringa C, Bloemers FW, van Weeghel M, Schomakers B, Coelho P, Posthuma JJ, Aronica E, Wiersinga WJ, van Vugt M, Wüst RCI. Appelman B, et al. Among authors: wiersinga wj. Nat Commun. 2025 Feb 18;16(1):1725. doi: 10.1038/s41467-025-56428-2. Nat Commun. 2025. PMID: 39966402 Free PMC article. No abstract available.

45

Reply: Muscle abnormalities in Long COVID.

Appelman B, Charlton BT, Goulding RP, Kerkhoff TJ, Breedveld EA, Noort W, Offringa C, Bloemers FW, van Weeghel M, Schomakers BV, Coelho P, Posthuma JJ, Aronica E, Wiersinga WJ, van Vugt M, Wüst RCI. Appelman B, et al. Among authors: wiersinga wj. Nat Commun. 2025 Feb 11;16(1):1491. doi: 10.1038/s41467-025-56431-7. Nat Commun. 2025. PMID: 39934110 Free PMC article. No abstract available.

46

Clinical subtypes in critically ill patients with sepsis: validation and parsimonious classifier model development.

van Amstel RBE, Rademaker E, Kennedy JN, Bos LDJ, Peters-Sengers H, Butler JM, Bruse N, Dongelmans DA, Kox M, Vlaar APJ, van der Poll T, Cremer OL, Seymour CW, van Vught LA. van Amstel RBE, et al. Among authors: van der poll t. Crit Care. 2025 Feb 4;29(1):58. doi: 10.1186/s13054-025-05256-3. Crit Care. 2025. PMID: 39905513 Free PMC article.

47

Increased FGF-19 levels following explantation in women with breast implant illness.

Azahaf S, Spit KA, de Blok CJM, Nanayakkara PWB. Azahaf S, et al. Among authors: nanayakkara pwb. Sci Rep. 2025 Jan 29;15(1):3652. doi: 10.1038/s41598-025-88013-4. Sci Rep. 2025. PMID: 39880914 Free PMC article.

48

The blood transcriptional response in patients developing intensive care unit-acquired pneumonia.

de Brabander J, Michels EHA, Butler JM, Reijnders TDY, van Engelen TSR, Leite GGF, Paling FP, Klarenbeek AM, Sie DLS, Boyer RE, Sweeney TE, Bonten MJM, Timbermont L, Malhotra-Kumar S, Kluytmans JAJW, Peters-Sengers H, van der Poll T; ASPIRE-ICU study team. de Brabander J, et al. Among authors: van der poll t. Eur Respir J. 2025 Apr 24;65(4):2400592. doi: 10.1183/13993003.00592-2024. Print 2025 Apr. Eur Respir J. 2025. PMID: 39848701 Free PMC article.

49

Decoding Sepsis Globally: Toward Precision Medicine through Clustering in Sub-Saharan Africa.

Leligdowicz A, Wiersinga WJ. Leligdowicz A, et al. Among authors: wiersinga wj. Am J Respir Crit Care Med. 2025 Mar;211(3):307-309. doi: 10.1164/rccm.202411-2331ED. Am J Respir Crit Care Med. 2025. PMID: 39847719 Free PMC article. No abstract available.

50

Leptospirosis, melioidosis, and rickettsioses in the vicious circle of neglect.

Tshokey T, Ko AI, Currie BJ, Munoz-Zanzi C, Goarant C, Paris DH, Dance DAB, Limmathurotsakul D, Birnie E, Bertherat E, Gongal G, Benschop J, Savelkoel J, Stenos J, Saraswati K, Robinson MT, Day NPJ, Graves SR, Belmain SR, Blacksell SD, Wiersinga WJ. Tshokey T, et al. Among authors: wiersinga wj. PLoS Negl Trop Dis. 2025 Jan 23;19(1):e0012796. doi: 10.1371/journal.pntd.0012796. eCollection 2025 Jan. PLoS Negl Trop Dis. 2025. PMID: 39847571 Free PMC article. Review.

51

The Role of Positron Emission Tomography Imaging in Breast Implant Illness.

Azahaf S, Spit KA, de Blok CJM, Bult P, Nanayakkara PWB. Azahaf S, et al. Among authors: nanayakkara pwb. Plast Reconstr Surg Glob Open. 2025 Jan 16;13(1):e6458. doi: 10.1097/GOX.0000000000006458. eCollection 2025 Jan. Plast Reconstr Surg Glob Open. 2025. PMID: 39823024 Free PMC article.

52

Aiming for precision: personalized medicine through sepsis subtyping.

Kolodyazhna A, Wiersinga WJ, van der Poll T. Kolodyazhna A, et al. Among authors: wiersinga wj, van der poll t. Burns Trauma. 2025 Jan 3;13:tkae073. doi: 10.1093/burnst/tkae073. eCollection 2025. Burns Trauma. 2025. PMID: 39759543 Free PMC article. Review.

53

Facilitators and barriers for the implementation of a transmural fall-prevention care pathway for older adults in the emergency department.

Charmant WM, Snoeker BAM, van Hout HPJ, Nauta IN, Boonstra F, Geleijn E, Veenhof C, Nanayakkara PWB. Charmant WM, et al. Among authors: nanayakkara pwb. PLoS One. 2024 Dec 31;19(12):e0314855. doi: 10.1371/journal.pone.0314855. eCollection 2024. PLoS One. 2024. PMID: 39739821 Free PMC article.

54

Isolating high-quality RNA for RNA-Seq from 10-year-old blood samples.

Portelli C, Seria E, Attard R, Barzine M, Esquinas-Roman EM, Borg Carbott F, Cassar K, Vella M, Scicluna BP, Ebejer JP, Farrugia R, Bezzina Wettinger S. Portelli C, et al. Among authors: scicluna bp. Sci Rep. 2024 Dec 28;14(1):30716. doi: 10.1038/s41598-024-80287-4. Sci Rep. 2024. PMID: 39730418 Free PMC article.

55

Temporal Transitions of the Hyperinflammatory and Hypoinflammatory Phenotypes in Critical Illness.

van Amstel RBE, Bartek B, Vlaar APJ, Gay E, van Vught LA, Cremer OL, Van der Poll T, Shapiro NI, Matthay MA, Calfee CS, Sinha P, Bos LDJ. van Amstel RBE, et al. Among authors: van der poll t. Am J Respir Crit Care Med. 2025 Mar;211(3):347-356. doi: 10.1164/rccm.202406-1241OC. Am J Respir Crit Care Med. 2025. PMID: 39642348

56

Longitudinal assessment of immunoglobulin response and disease progression in critically ill patients with community acquired pneumonia.

Rademaker E, Vernooij LM, van der Poll T, Bonten MJM, Leavis H, Cremer OL, Derde LPG. Rademaker E, et al. Among authors: van der poll t. Crit Care. 2024 Dec 5;28(1):405. doi: 10.1186/s13054-024-05197-3. Crit Care. 2024. PMID: 39639324 Free PMC article.

57

International multi-cohort analysis identifies novel framework for quantifying immune dysregulation in critical illness: results of the SUBSPACE consortium.

Moore AR, Zheng H, Ganesan A, Hasin-Brumshtein Y, Maddali MV, Levitt JE, van der Poll T, Scicluna BP, Giamarellos-Bourboulis EJ, Kotsaki A, Martin-Loeches I, Garduno A, Rothman RE, Sevransky J, Wright DW, Atreya MR, Moldawer LL, Efron PA, Marcela K, Karvunidis T, Giannini HM, Meyer NJ, Sweeney TE, Rogers AJ, Khatri P. Moore AR, et al. Among authors: scicluna bp, van der poll t. bioRxiv [Preprint]. 2024 Nov 15:2024.11.12.623298. doi: 10.1101/2024.11.12.623298. bioRxiv. 2024. Update in: Nat Med. 2025 Sep 30. doi: 10.1038/s41591-025-03956-5. PMID: 39605502 Free PMC article. Updated. Preprint.

58

Clinical Subtype Trajectories in Sepsis Patients Admitted to the ICU: A Secondary Analysis of an Observational Study.

Slim MA, van Amstel RBE, Müller MCA, Cremer OL, Vlaar APJ, van der Poll T, Wiersinga WJ, Seymour CW, van Vught LA; MARS Consortium. Slim MA, et al. Among authors: wiersinga wj, van der poll t. Crit Care Explor. 2024 Nov 14;6(11):e1176. doi: 10.1097/CCE.0000000000001176. eCollection 2024 Nov. Crit Care Explor. 2024. PMID: 39555471 Free PMC article.

59

Gut Microbiome in Human Melioidosis: Composition and Resistome Dynamics from Diagnosis to Discovery.

Chowdhury S, Kullberg RFJ, Haak BW, Duran C, Earny VA, Eshwara VK, Lawley TD, Wiersinga WJ, Mukhopadhyay C. Chowdhury S, et al. Among authors: wiersinga wj. Open Forum Infect Dis. 2024 Nov 5;11(11):ofae654. doi: 10.1093/ofid/ofae654. eCollection 2024 Nov. Open Forum Infect Dis. 2024. PMID: 39553288 Free PMC article.

60

Proteomic profiling of neutrophils and plasma in community-acquired pneumonia reveals crucial proteins in diverse biological pathways linked to clinical outcome.

Michels EHA, Chouchane O, de Brabander J, de Vos AF, Faber DR, Douma RA, Smit ER, Wiersinga WJ, van den Biggelaar M, van der Poll T, Hoogendijk AJ. Michels EHA, et al. Among authors: wiersinga wj, van der poll t, de vos af. Front Immunol. 2024 Oct 18;15:1470383. doi: 10.3389/fimmu.2024.1470383. eCollection 2024. Front Immunol. 2024. PMID: 39493755 Free PMC article.

61

Rapid and Robust Identification of Sepsis Using SeptiCyte RAPID in a Heterogeneous Patient Population.

Balk R, Esper AM, Martin GS, Miller RR 3rd, Lopansri BK, Burke JP, Levy M, Rothman RE, D'Alessio FR, Sidhaye VK, Aggarwal NR, Greenberg JA, Yoder M, Patel G, Gilbert E, Parada JP, Afshar M, Kempker JA, van der Poll T, Schultz MJ, Scicluna BP, Klein Klouwenberg PMC, Liebler J, Blodget E, Kumar S, Mei XW, Navalkar K, Yager TD, Sampson D, Kirk JT, Cermelli S, Davis RF, Brandon RB. Balk R, et al. Among authors: scicluna bp, van der poll t. J Clin Med. 2024 Oct 10;13(20):6044. doi: 10.3390/jcm13206044. J Clin Med. 2024. PMID: 39457994 Free PMC article.

62

Causal inference can lead us to modifiable mechanisms and informative archetypes in sepsis.

Baillie JK, Angus D, Burnham K, Calandra T, Calfee C, Gutteridge A, Hacohen N, Khatri P, Langley R, Ma'ayan A, Marshall J, Maslove D, Prescott HC, Rowan K, Scicluna BP, Seymour C, Shankar-Hari M, Shapiro N, Joost Wiersinga W, Singer M, Randolph AG. Baillie JK, et al. Among authors: scicluna bp. Intensive Care Med. 2024 Dec;50(12):2031-2042. doi: 10.1007/s00134-024-07665-4. Epub 2024 Oct 21. Intensive Care Med. 2024. PMID: 39432104 Free PMC article. Review.

63

Quality of care after a horizontal merger between two large academic hospitals.

Wissink IJA, Schinkel M, Peters-Sengers H, Jones SA, Vlaar APJ, Kruijthof KJ, Wiersinga WJ. Wissink IJA, et al. Among authors: wiersinga wj. Heliyon. 2024 Sep 29;10(19):e38311. doi: 10.1016/j.heliyon.2024.e38311. eCollection 2024 Oct 15. Heliyon. 2024. PMID: 39430517 Free PMC article.

64

Quantitative characterization of immune cells by measuring cellular signal transduction pathway activity.

Bouwman W, Verhaegh W, van Doorn A, Raymakers R, van der Poll T, van de Stolpe A. Bouwman W, et al. Among authors: van der poll t. Sci Rep. 2024 Oct 18;14(1):24487. doi: 10.1038/s41598-024-75666-w. Sci Rep. 2024. PMID: 39424625 Free PMC article.

65

Empirical antibiotic therapy for sepsis: save the anaerobic microbiota.

Kullberg RFJ, Haak BW, Chanderraj R, Prescott HC, Dickson RP, Wiersinga WJ. Kullberg RFJ, et al. Among authors: wiersinga wj. Lancet Respir Med. 2025 Jan;13(1):92-100. doi: 10.1016/S2213-2600(24)00257-1. Epub 2024 Oct 11. Lancet Respir Med. 2025. PMID: 39401510 Review.

66

Strategies for implementation of a transmural fall-prevention care pathway for older adults with fall-related injuries at the emergency department.

Charmant WM, Snoeker BAM, van Hout HPJ, Geleijn E, van der Velde N, Veenhof C, Nanayakkara PWB. Charmant WM, et al. Among authors: nanayakkara pwb. BMC Emerg Med. 2024 Oct 11;24(1):188. doi: 10.1186/s12873-024-01085-9. BMC Emerg Med. 2024. PMID: 39394063 Free PMC article.

67

Unraveling Sepsis Epidemiology in a Low- and Middle-Income Intensive Care Setting Reveals the Alarming Burden of Tropical Infections and Antimicrobial Resistance: A Prospective Observational Study (MARS-India).

Virk HS, Biemond JJ, Earny VA, Chowdhury S, Frölke RI, Khanna SM, Shanbhag V, Rao S, Acharya RV, Balakrishnan JM, Eshwara VK, Varma MD, van der Poll T, Wiersinga WJ, Mukhopadhyay C. Virk HS, et al. Among authors: wiersinga wj, van der poll t. Clin Infect Dis. 2025 Feb 5;80(1):101-107. doi: 10.1093/cid/ciae486. Clin Infect Dis. 2025. PMID: 39352692 Free PMC article.

68

Effect of mesenchymal stem cells on the host response in severe community-acquired pneumonia.

Reijnders TDY, Laterre PF, François B, Sánchez García M, van Engelen TSR, Sie D, Scicluna BP, Ostanin DV, Galinsky KJ, Butler JM, Lombardo E, van der Poll T; SEPCELL study group. Reijnders TDY, et al. Among authors: scicluna bp, van der poll t. Thorax. 2024 Oct 16;79(11):1086-1090. doi: 10.1136/thorax-2024-222026. Thorax. 2024. PMID: 39322407 Free PMC article. Clinical Trial.

69

Topical adjunctive treatment with flagellin augments pulmonary neutrophil responses and reduces bacterial dissemination in multidrug-resistant K. pneumoniae infection.

van Linge CCA, Kullberg RFJ, Chouchane O, Roelofs JJTH, Goessens WHF, van 't Veer C, Sirard JC, de Vos AF, van der Poll T. van Linge CCA, et al. Among authors: van t veer c, van der poll t, de vos af. Front Immunol. 2024 Sep 4;15:1450486. doi: 10.3389/fimmu.2024.1450486. eCollection 2024. Front Immunol. 2024. PMID: 39295863 Free PMC article.

70

Single-cell transcriptomics reveals subset-specific metabolic profiles underpinning the bronchial epithelial response to flagellin.

Ramirez-Moral I, Schuurman AR, van Linge CCA, Butler JM, Yu X, de Haan K, van Leeuwen S, de Vos AF, de Jong MD, Vieira Braga FA, van der Poll T. Ramirez-Moral I, et al. Among authors: van der poll t, de vos af. iScience. 2024 Aug 3;27(9):110662. doi: 10.1016/j.isci.2024.110662. eCollection 2024 Sep 20. iScience. 2024. PMID: 39252969 Free PMC article.

71

A Prospective Observational Clinical Cohort of Women with Suspected Breast Implant Illness.

Spit KA, Azahaf S, de Blok CJM, Nanayakkara PWB. Spit KA, et al. Among authors: nanayakkara pwb. J Clin Med. 2024 Jul 27;13(15):4394. doi: 10.3390/jcm13154394. J Clin Med. 2024. PMID: 39124661 Free PMC article.

72

[A redesign of the acute care chain: evaluation of acute care in Den Helder, The Netherlands].

van Goor MA, Minderhoud TC, Hengeveld E, Schouten B, Kleppe CG, Kremers MNT, Haak-van der Lely F, Nanayakkara PWB. van Goor MA, et al. Among authors: nanayakkara pwb. Ned Tijdschr Geneeskd. 2024 Jul 24;168:D8019. Ned Tijdschr Geneeskd. 2024. PMID: 39087464 Dutch.

73

Ultrasound versus MRI for evaluation of silicone leakage from silicone breast implants.

Spit KA, Azahaf S, de Blok CJM, Duvivier KM, Wiebenga OT, Nanayakkara PWB. Spit KA, et al. Among authors: nanayakkara pwb. Heliyon. 2024 Jun 19;10(12):e33325. doi: 10.1016/j.heliyon.2024.e33325. eCollection 2024 Jun 30. Heliyon. 2024. PMID: 39022001 Free PMC article.

74

Diagnostic agreement between emergency medical service and emergency department physicians, a prospective multicentre study.

Veldhuis LI, Gouma P, Nanayakkara PWB, Ludikhuize J. Veldhuis LI, et al. Among authors: nanayakkara pwb. BMC Emerg Med. 2024 Jul 18;24(1):120. doi: 10.1186/s12873-024-01041-7. BMC Emerg Med. 2024. PMID: 39020318 Free PMC article.

75

Pulmonary herpes simplex virus and cytomegalovirus in patients with acute respiratory distress syndrome related to COVID-19.

Boers LS, van Someren Gréve F, van Hattem JM, de Brabander J, Zwaan T, van Willigen H, Cornelissen M, de Jong M, van der Poll T, Duitman J, Schinkel J, Bos LDJ; and the OPPORTUNE consortium, the Amsterdam UMC COVID study group, the ArtDECO consortium. Boers LS, et al. Among authors: van der poll t. Intensive Care Med. 2024 Aug;50(8):1251-1264. doi: 10.1007/s00134-024-07529-x. Epub 2024 Jul 17. Intensive Care Med. 2024. PMID: 39017695 Free PMC article.

76

Enhancing sepsis biomarker development: key considerations from public and private perspectives.

Llitjos JF, Carrol ED, Osuchowski MF, Bonneville M, Scicluna BP, Payen D, Randolph AG, Witte S, Rodriguez-Manzano J, François B; Sepsis biomarker workshop group. Llitjos JF, et al. Among authors: scicluna bp. Crit Care. 2024 Jul 13;28(1):238. doi: 10.1186/s13054-024-05032-9. Crit Care. 2024. PMID: 39003476 Free PMC article. Review.

77

Dysregulation of Host-Pathogen Interactions in Sepsis: Host-Related Factors.

Joosten SCM, Wiersinga WJ, Poll TV. Joosten SCM, et al. Among authors: wiersinga wj. Semin Respir Crit Care Med. 2024 Aug;45(4):469-478. doi: 10.1055/s-0044-1787554. Epub 2024 Jul 1. Semin Respir Crit Care Med. 2024. PMID: 38950605 Free PMC article. Review.

78

Patients' Perspectives and Feasibility of Home Monitoring in Acute Care: The AcuteCare@Home Flash Mob Study.

Weijers J, Prins MLM, van Dam DGHA; AcuteCare@Home Study Group; van Nieuwkoop C, Alsma J, Haak HR, V Uffen JW, Kaasjager KAH, Kremers MNT, Nanayakkara PWB, Stassen PM, Groeneveld GH. Weijers J, et al. Among authors: nanayakkara pwb. Telemed J E Health. 2024 Oct;30(10):2563-2572. doi: 10.1089/tmj.2024.0166. Epub 2024 Jun 28. Telemed J E Health. 2024. PMID: 38938204

79

Association between butyrate-producing gut bacteria and the risk of infectious disease hospitalisation: results from two observational, population-based microbiome studies.

Kullberg RFJ, Wikki I, Haak BW, Kauko A, Galenkamp H, Peters-Sengers H, Butler JM, Havulinna AS, Palmu J, McDonald D, Benchraka C, Abdel-Aziz MI, Prins M, Maitland van der Zee AH, van den Born BJ, Jousilahti P, de Vos WM, Salomaa V, Knight R, Lahti L, Nieuwdorp M, Niiranen T, Wiersinga WJ. Kullberg RFJ, et al. Among authors: wiersinga wj. Lancet Microbe. 2024 Sep;5(9):100864. doi: 10.1016/S2666-5247(24)00079-X. Epub 2024 Jun 20. Lancet Microbe. 2024. PMID: 38909617 Free article.

80

Resolving the Dilemma on Continuous vs Intermittent β-Lactam Antibiotics in Sepsis.

Wiersinga WJ, van Agtmael MA. Wiersinga WJ, et al. JAMA. 2024 Aug 27;332(8):623-625. doi: 10.1001/jama.2024.10168. JAMA. 2024. PMID: 38864160 No abstract available.

81

Adverse events at the end of life of hospital patients with or without a condition relevant for palliative care: a nationwide retrospective record review study in the Netherlands.

Schouten B, van Schoten SM, Bijnsdorp FM, Merten H, Nanayakkara PWB, Reyners AKL, Francke AL, Wagner C. Schouten B, et al. Among authors: nanayakkara pwb. BMC Palliat Care. 2024 Jun 10;23(1):145. doi: 10.1186/s12904-024-01461-z. BMC Palliat Care. 2024. PMID: 38858703 Free PMC article.

82

A Robust Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Specific T- and B-Cell Response Is Associated With Early Viral Clearance in SARS-CoV-2 Omicron-Infected Immunocompromised Individuals.

Vergouwe M, Biemond JJ, van der Straten K, van Pul L, Kerster G, Claireaux M, Burger JA, van Dort KA, Kootstra NA, Jonges M, Welkers MRA, Hazenberg MD, Peters-Sengers H, van Gils MJ, Wiersinga WJ, Birnie E, de Bree GJ; TURN-COVID study group. Vergouwe M, et al. Among authors: wiersinga wj. J Infect Dis. 2024 Oct 16;230(4):e860-e871. doi: 10.1093/infdis/jiae306. J Infect Dis. 2024. PMID: 38843052 Free PMC article.

83

Breast implant iatrogenics: challenging the safety narrative.

Azahaf S, Spit KA, de Blok CJM, Willging L, Rolfs H, Nanayakkara PWB. Azahaf S, et al. Among authors: nanayakkara pwb. Front Glob Womens Health. 2024 May 17;5:1359106. doi: 10.3389/fgwh.2024.1359106. eCollection 2024. Front Glob Womens Health. 2024. PMID: 38832108 Free PMC article. No abstract available.

84

Appropriate use of blood cultures in the emergency department through machine learning (ABC): study protocol for a randomised controlled non-inferiority trial.

van der Zaag AY, Bhagirath SC, Boerman AW, Schinkel M, Paranjape K, Azijli K, Ridderikhof ML, Lie M, Lissenberg-Witte B, Schade R, Wiersinga J, de Jonge R, Nanayakkara PWB. van der Zaag AY, et al. Among authors: nanayakkara pwb. BMJ Open. 2024 May 31;14(5):e084053. doi: 10.1136/bmjopen-2024-084053. BMJ Open. 2024. PMID: 38821574 Free PMC article.

85

Towards personalized medicine: a scoping review of immunotherapy in sepsis.

Slim MA, van Mourik N, Bakkerus L, Fuller K, Acharya L, Giannidis T, Dionne JC, Oczkowski SJW, Netea MG, Pickkers P, Giamarellos-Bourboulis EJ, Müller MCA, van der Poll T, Wiersinga WJ; ImmunoSep Consortium; Vlaar APJ, van Vught LA. Slim MA, et al. Among authors: wiersinga wj, van der poll t. Crit Care. 2024 May 28;28(1):183. doi: 10.1186/s13054-024-04964-6. Crit Care. 2024. PMID: 38807151 Free PMC article.

86

Examining pancreatic stone protein response in ICU-acquired bloodstream infections: a matched event analysis.

Verlaan D, Derde LPG, van der Poll T, Bonten MJM, Cremer OL. Verlaan D, et al. Among authors: van der poll t. Intensive Care Med Exp. 2024 May 28;12(1):50. doi: 10.1186/s40635-024-00634-7. Intensive Care Med Exp. 2024. PMID: 38805144 Free PMC article.

87

Sleep assessment using EEG-based wearables - A systematic review.

de Gans CJ, Burger P, van den Ende ES, Hermanides J, Nanayakkara PWB, Gemke RJBJ, Rutters F, Stenvers DJ. de Gans CJ, et al. Among authors: nanayakkara pwb. Sleep Med Rev. 2024 Aug;76:101951. doi: 10.1016/j.smrv.2024.101951. Epub 2024 May 7. Sleep Med Rev. 2024. PMID: 38754209 Free article.

88

Inflammatory subphenotypes previously identified in ARDS are associated with mortality at intensive care unit discharge: a secondary analysis of a prospective observational study.

Slim MA, van Amstel RBE, Bos LDJ, Cremer OL; MARS Consortium; Wiersinga WJ, van der Poll T, van Vught LA. Slim MA, et al. Among authors: wiersinga wj, van der poll t. Crit Care. 2024 May 7;28(1):151. doi: 10.1186/s13054-024-04929-9. Crit Care. 2024. PMID: 38715131 Free PMC article.

89

Recellularization via electroporation therapy of the duodenum combined with glucagon-like peptide-1 receptor agonist to replace insulin therapy in patients with type 2 diabetes: 12-month results of a first-in-human study.

Busch CBE, Meiring S, van Baar ACG, Holleman F, Nieuwdorp M, Bergman JJGHM. Busch CBE, et al. Among authors: holleman f. Gastrointest Endosc. 2024 Nov;100(5):896-904. doi: 10.1016/j.gie.2024.04.2904. Epub 2024 Apr 29. Gastrointest Endosc. 2024. PMID: 38692517

90

From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU.

Gordon AC, Alipanah-Lechner N, Bos LD, Dianti J, Diaz JV, Finfer S, Fujii T, Giamarellos-Bourboulis EJ, Goligher EC, Gong MN, Karakike E, Liu VX, Lumlertgul N, Marshall JC, Menon DK, Meyer NJ, Munroe ES, Myatra SN, Ostermann M, Prescott HC, Randolph AG, Schenck EJ, Seymour CW, Shankar-Hari M, Singer M, Smit MR, Tanaka A, Taccone FS, Thompson BT, Torres LK, van der Poll T, Vincent JL, Calfee CS. Gordon AC, et al. Among authors: van der poll t. Am J Respir Crit Care Med. 2024 Jul 15;210(2):155-166. doi: 10.1164/rccm.202311-2086SO. Am J Respir Crit Care Med. 2024. PMID: 38687499 Free PMC article. Review.

91

Optimal timing for the Modified Early Warning Score for prediction of short-term critical illness in the acute care chain: a prospective observational study.

Veldhuis LI, Kuit M, Karim L, Ridderikhof ML, Nanayakkara PW, Ludikhuize J. Veldhuis LI, et al. Among authors: nanayakkara pw. Emerg Med J. 2024 May 28;41(6):363-367. doi: 10.1136/emermed-2022-212733. Emerg Med J. 2024. PMID: 38670792 Free PMC article.

92

Improving emergency department flow by introducing a simple time out moment (The TRAFFIC LIGHT study).

Overgaauw AJ, Ligthart M, Azilji K, Minderhoud TC, Sikkens JJ, Biesheuvel TH, Nanayakkara PW. Overgaauw AJ, et al. Among authors: nanayakkara pw. Acute Med. 2024;23(1):4-10. doi: 10.52964/AMJA.0966. Acute Med. 2024. PMID: 38619164

93

Validation of SeptiCyte RAPID to Discriminate Sepsis from Non-Infectious Systemic Inflammation.

Balk R, Esper AM, Martin GS, Miller RR 3rd, Lopansri BK, Burke JP, Levy M, Opal S, Rothman RE, D'Alessio FR, Sidhaye VK, Aggarwal NR, Greenberg JA, Yoder M, Patel G, Gilbert E, Parada JP, Afshar M, Kempker JA, van der Poll T, Schultz MJ, Scicluna BP, Klein Klouwenberg PMC, Liebler J, Blodget E, Kumar S, Navalkar K, Yager TD, Sampson D, Kirk JT, Cermelli S, Davis RF, Brandon RB. Balk R, et al. Among authors: scicluna bp, van der poll t. J Clin Med. 2024 Feb 20;13(5):1194. doi: 10.3390/jcm13051194. J Clin Med. 2024. PMID: 38592057 Free PMC article.

94

Gut barrier dysfunction and the risk of ICU-acquired bacteremia- a case-control study.

Varkila MRJ, Verboom DM, Derde LPG, van der Poll T, Bonten MJM, Cremer OL; MARS consortium. Varkila MRJ, et al. Among authors: van der poll t. Ann Intensive Care. 2024 Mar 27;14(1):42. doi: 10.1186/s13613-024-01280-8. Ann Intensive Care. 2024. PMID: 38536623 Free PMC article.

95

Breath metabolomics for diagnosis of acute respiratory distress syndrome.

Zhang S, Hagens LA, Heijnen NFL, Smit MR, Brinkman P, Fenn D, van der Poll T, Schultz MJ, Bergmans DCJJ, Schnabel RM, Bos LDJ; DARTS Consortium. Zhang S, et al. Among authors: van der poll t. Crit Care. 2024 Mar 23;28(1):96. doi: 10.1186/s13054-024-04882-7. Crit Care. 2024. PMID: 38521944 Free PMC article.

96

Genome-wide analyses in Lyme borreliosis: identification of a genetic variant associated with disease susceptibility and its immunological implications.

Vrijmoeth HD, Ursinus J, Botey-Bataller J, Kuijpers Y, Chu X, van de Schoor FR, Scicluna BP, Xu CJ, Netea MG, Kullberg BJ, van den Wijngaard CC, Li Y, Hovius JW, Joosten LAB. Vrijmoeth HD, et al. Among authors: scicluna bp. BMC Infect Dis. 2024 Mar 21;24(1):337. doi: 10.1186/s12879-024-09217-z. BMC Infect Dis. 2024. PMID: 38515037 Free PMC article.

97

Monocyte state 1 (MS1) cells in critically ill patients with sepsis or non-infectious conditions: association with disease course and host response.

Leite GGF, de Brabander J, Michels EHA, Butler JM, Cremer OL, Scicluna BP, Sweeney TE, Reyes M, Salomao R, Peters-Sengers H, van der Poll T. Leite GGF, et al. Among authors: scicluna bp, van der poll t. Crit Care. 2024 Mar 19;28(1):88. doi: 10.1186/s13054-024-04868-5. Crit Care. 2024. PMID: 38504349 Free PMC article.

98

Ferritin heavy chain supports stability and function of the regulatory T cell lineage.

Wu Q, Carlos AR, Braza F, Bergman ML, Kitoko JZ, Bastos-Amador P, Cuadrado E, Martins R, Oliveira BS, Martins VC, Scicluna BP, Landry JJ, Jung FE, Ademolue TW, Peitzsch M, Almeida-Santos J, Thompson J, Cardoso S, Ventura P, Slot M, Rontogianni S, Ribeiro V, Domingues VDS, Cabral IA, Weis S, Groth M, Ameneiro C, Fidalgo M, Wang F, Demengeot J, Amsen D, Soares MP. Wu Q, et al. Among authors: scicluna bp. EMBO J. 2024 Apr;43(8):1445-1483. doi: 10.1038/s44318-024-00064-x. Epub 2024 Mar 18. EMBO J. 2024. PMID: 38499786 Free PMC article.

99

Fatal Adverse Events in Femoral Neck Fracture Patients Undergoing Hemiarthroplasty or Total Hip Arthroplasty-A Retrospective Record Review Study in a Nationwide Sample of Deceased Patients.

Schouten B, Baartmans M, van Eikenhorst L, Gerritsen GP, Merten H, van Schoten S, Nanayakkara PWB, Wagner C. Schouten B, et al. Among authors: nanayakkara pwb. J Patient Saf. 2024 Aug 1;20(5):e59-e72. doi: 10.1097/PTS.0000000000001226. Epub 2024 Mar 7. J Patient Saf. 2024. PMID: 38466141

100

A Comparative Analysis of Local and Systemic Immunological Biomarkers in Females With Breast Implants and Capsular Contracture.

Spit KA, Azahaf S, de Blok CJM, Bachour Y, Castricum KCM, Thijssen VLJL, Oudejans MAH, Rustemeyer T, Nanayakkara PWB. Spit KA, et al. Among authors: nanayakkara pwb. Aesthet Surg J Open Forum. 2024 Feb 21;6:ojae008. doi: 10.1093/asjof/ojae008. eCollection 2024. Aesthet Surg J Open Forum. 2024. PMID: 38465196 Free PMC article.

101

Lymphopenia is associated with broad host response aberrations in community-acquired pneumonia.

Doeleman SE, Reijnders TDY, Joosten SCM, Schuurman AR, van Engelen TSR, Verhoeff J, Léopold V, Brands X, Haak BW, Prins JM, Kanglie MMNP, van den Berk IAH, Faber DR, Douma RA, Stoker J, Saris A, Garcia Vallejo JJ, Wiersinga WJ, van der Poll T. Doeleman SE, et al. Among authors: wiersinga wj, van der poll t. J Infect. 2024 Apr;88(4):106131. doi: 10.1016/j.jinf.2024.106131. Epub 2024 Feb 29. J Infect. 2024. PMID: 38431153 Free article.

102

Reframing sepsis immunobiology for translation: towards informative subtyping and targeted immunomodulatory therapies.

Shankar-Hari M, Calandra T, Soares MP, Bauer M, Wiersinga WJ, Prescott HC, Knight JC, Baillie KJ, Bos LDJ, Derde LPG, Finfer S, Hotchkiss RS, Marshall J, Openshaw PJM, Seymour CW, Venet F, Vincent JL, Le Tourneau C, Maitland-van der Zee AH, McInnes IB, van der Poll T. Shankar-Hari M, et al. Among authors: wiersinga wj, van der poll t. Lancet Respir Med. 2024 Apr;12(4):323-336. doi: 10.1016/S2213-2600(23)00468-X. Epub 2024 Feb 23. Lancet Respir Med. 2024. PMID: 38408467 Free PMC article. Review.

103

The shifting lipidomic landscape of blood monocytes and neutrophils during pneumonia.

Schuurman AR, Chouchane O, Butler JM, Peters-Sengers H, Joosten S, Brands X, Haak BW, Otto NA, Uhel F, Klarenbeek A, van Linge CC, van Kampen A, Pras-Raves M, van Weeghel M, van Eijk M, Ferraz MJ, Faber DR, de Vos A, Scicluna BP, Vaz FM, Wiersinga WJ, van der Poll T. Schuurman AR, et al. Among authors: scicluna bp, wiersinga wj, van der poll t. JCI Insight. 2024 Feb 22;9(4):e164400. doi: 10.1172/jci.insight.164400. JCI Insight. 2024. PMID: 38385743 Free PMC article.

104

Silicone Migration from Intact Saline Breast Implants.

Azahaf S, Spit KA, de Blok CJM, Bult P, Nanayakkara PWB. Azahaf S, et al. Among authors: nanayakkara pwb. Plast Reconstr Surg Glob Open. 2024 Feb 8;12(2):e5608. doi: 10.1097/GOX.0000000000005608. eCollection 2024 Feb. Plast Reconstr Surg Glob Open. 2024. PMID: 38333026 Free PMC article.

105

Impact of Blood Culture Contamination on Antibiotic Use, Resource Utilization, and Clinical Outcomes: A Retrospective Cohort Study in Dutch and US Hospitals.

Schinkel M, Boerman A, Carroll K, Cosgrove SE, Hsu YJ, Klein E, Nanayakkara P, Schade R, Wiersinga WJ, Fabre V. Schinkel M, et al. Among authors: wiersinga wj. Open Forum Infect Dis. 2023 Dec 22;11(2):ofad644. doi: 10.1093/ofid/ofad644. eCollection 2024 Feb. Open Forum Infect Dis. 2023. PMID: 38312218 Free PMC article.

106

The IRAK-M death domain: a tale of three surfaces.

Gürkan B, Poelman H, Pereverzeva L, Kruijswijk D, de Vos AF, Groenen AG, Nollet EE, Wichapong K, Lutgens E, van der Poll T, Du J, Wiersinga WJ, Nicolaes GAF, van 't Veer C. Gürkan B, et al. Among authors: wiersinga wj, van t veer c, van der poll t, de vos af. Front Mol Biosci. 2024 Jan 10;10:1265455. doi: 10.3389/fmolb.2023.1265455. eCollection 2023. Front Mol Biosci. 2024. PMID: 38268724 Free PMC article.

107

The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia.

Chouchane O, Schuurman AR, Reijnders TDY, Peters-Sengers H, Butler JM, Uhel F, Schultz MJ, Bonten MJ, Cremer OL, Calfee CS, Matthay MA, Langley RJ, Alipanah-Lechner N, Kingsmore SF, Rogers A, van Weeghel M, Vaz FM, van der Poll T. Chouchane O, et al. Among authors: van der poll t. Am J Respir Crit Care Med. 2024 Apr 15;209(8):973-986. doi: 10.1164/rccm.202308-1321OC. Am J Respir Crit Care Med. 2024. PMID: 38240721 Free PMC article.

108

Can acutely ill patients predict their outcomes? A scoping review.

Mols EM, Haak H, Holland M, Schouten B, Ibsen S, Merten H, Christensen EF, Nanayakkara PWB, Nickel CH, Weichert I, Kellett J, Subbe CP, Kremers MNT; Safer@Home Research Consortium. Mols EM, et al. Among authors: nanayakkara pwb. Emerg Med J. 2024 May 28;41(6):342-349. doi: 10.1136/emermed-2022-213000. Emerg Med J. 2024. PMID: 38238065

109

Immunostimulatory Effect of Flagellin on MDR-Klebsiella-Infected Human Airway Epithelial Cells.

van Linge CCA, Hulme KD, Peters-Sengers H, Sirard JC, Goessens WHF, de Jong MD, Russell CA, de Vos AF, van der Poll T. van Linge CCA, et al. Among authors: van der poll t, de vos af. Int J Mol Sci. 2023 Dec 25;25(1):309. doi: 10.3390/ijms25010309. Int J Mol Sci. 2023. PMID: 38203480 Free PMC article.

110

[Unplanned Emergency Department return visits by older patients].

van Dam CS, Muller M, Nanayakkara PW. van Dam CS, et al. Among authors: nanayakkara pw. Ned Tijdschr Geneeskd. 2023 Nov 23;167:D7908. Ned Tijdschr Geneeskd. 2023. PMID: 38175576 Dutch.

111

The pathophysiology of sepsis and precision-medicine-based immunotherapy.

Giamarellos-Bourboulis EJ, Aschenbrenner AC, Bauer M, Bock C, Calandra T, Gat-Viks I, Kyriazopoulou E, Lupse M, Monneret G, Pickkers P, Schultze JL, van der Poll T, van de Veerdonk FL, Vlaar APJ, Weis S, Wiersinga WJ, Netea MG. Giamarellos-Bourboulis EJ, et al. Among authors: wiersinga wj, van der poll t. Nat Immunol. 2024 Jan;25(1):19-28. doi: 10.1038/s41590-023-01660-5. Epub 2024 Jan 2. Nat Immunol. 2024. PMID: 38168953 Review.

112

Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine.

Cajander S, Kox M, Scicluna BP, Weigand MA, Mora RA, Flohé SB, Martin-Loeches I, Lachmann G, Girardis M, Garcia-Salido A, Brunkhorst FM, Bauer M, Torres A, Cossarizza A, Monneret G, Cavaillon JM, Shankar-Hari M, Giamarellos-Bourboulis EJ, Winkler MS, Skirecki T, Osuchowski M, Rubio I, Bermejo-Martin JF, Schefold JC, Venet F. Cajander S, et al. Among authors: scicluna bp. Lancet Respir Med. 2024 Apr;12(4):305-322. doi: 10.1016/S2213-2600(23)00330-2. Epub 2023 Dec 21. Lancet Respir Med. 2024. PMID: 38142698 Free article. Review.

113

Tracheal epithelial cell-exosome-derived MiR-21-5p inhibits alveolar macrophage pyroptosis to resist pulmonary bacterial infection through PIK3CD-autophagy pathway.

Wang J, Gan L, Li F, Li Q, Wu T, Wu Z, Chen P, Scicluna BP, Feng X, Gu J, Han W, Li N, Lei L. Wang J, et al. Among authors: scicluna bp. Life Sci. 2024 Jan 1;336:122340. doi: 10.1016/j.lfs.2023.122340. Epub 2023 Dec 12. Life Sci. 2024. PMID: 38092143

114

Platelets of COVID-19 patients display mitochondrial dysfunction, oxidative stress, and energy metabolism failure compatible with cell death.

Léopold V, Chouchane O, Butler JM, Schuurman AR, Michels EHA, de Brabander J, Schomakers BV, van Weeghel M, Picavet-Havik DI, Grootemaat AE, Douma RA, Reijnders TDY, Klarenbeek AM, Appelman B; Amsterdam University Medical Center COVID-19 Biobank Study Groupd.vandebeek@amsterdamumc.nl; Wiersinga WJ, van der Wel NN, den Dunnen J, Houtkooper RH, Van't Veer C, van der Poll T; Amsterdam University Medical Center COVID-19 Biobank Study Group. Léopold V, et al. Among authors: wiersinga wj, van t veer c, van der poll t. Res Pract Thromb Haemost. 2023 Sep 28;7(7):102213. doi: 10.1016/j.rpth.2023.102213. eCollection 2023 Oct. Res Pract Thromb Haemost. 2023. PMID: 38077825 Free PMC article.

115

High-dimensional phenotyping of the peripheral immune response in community-acquired pneumonia.

Reijnders TDY, Schuurman AR, Verhoeff J, van den Braber M, Douma RA, Faber DR, Paul AGA, Wiersinga WJ, Saris A, Garcia Vallejo JJ, van der Poll T. Reijnders TDY, et al. Among authors: wiersinga wj, van der poll t. Front Immunol. 2023 Nov 24;14:1260283. doi: 10.3389/fimmu.2023.1260283. eCollection 2023. Front Immunol. 2023. PMID: 38077404 Free PMC article.

116

Solid-Phase Synthesis of Caged Luminescent Peptides via Side Chain Anchoring.

Sondag D, Heming JJA, Löwik DWPM, Krivosheeva E, Lejeune D, van Geffen M, Van't Veer C, van Heerde WL, Beens MCJ, Kuijpers BHM, Boltje TJ, Rutjes FPJT. Sondag D, et al. Among authors: van t veer c. Bioconjug Chem. 2023 Dec 20;34(12):2234-2242. doi: 10.1021/acs.bioconjchem.3c00381. Epub 2023 Dec 6. Bioconjug Chem. 2023. PMID: 38055970 Free PMC article.

117

Platelets interact with CD169⁺ macrophages and cDC1 and enhance liposome-induced CD8⁺ T cell responses.

Grabowska J, Léopold V, Olesek K, Nijen Twilhaar MK, Affandi AJ, Brouwer MC, Jongerius I, Verschoor A, van Kooten C, van Kooyk Y, Storm G, van 't Veer C, den Haan JMM. Grabowska J, et al. Among authors: van t veer c. Front Immunol. 2023 Nov 20;14:1290272. doi: 10.3389/fimmu.2023.1290272. eCollection 2023. Front Immunol. 2023. PMID: 38054006 Free PMC article.

118

Host Response Changes and Their Association with Mortality in COVID-19 Patients with Lymphopenia.

Michels EHA, Appelman B, de Brabander J, van Amstel RBE, van Linge CCA, Chouchane O, Reijnders TDY, Schuurman AR, Sulzer TAL, Klarenbeek AM, Douma RA, Bos LDJ, Wiersinga WJ, Peters-Sengers H, van der Poll T; Amsterdam UMC COVID-19 Biobank Study Group. Michels EHA, et al. Among authors: wiersinga wj, van der poll t. Am J Respir Crit Care Med. 2024 Feb 15;209(4):402-416. doi: 10.1164/rccm.202305-0890OC. Am J Respir Crit Care Med. 2024. PMID: 37948687 Free PMC article.

119

The alveolar fibroproliferative response in moderate to severe COVID-19-related acute respiratory distress syndrome and 1-yr follow-up.

Zhang S, Boers LS, de Brabander J, van den Heuvel LB, Blok SG, Kullberg RFJ, Smids-Dierdorp BS, Dekker T, Aberson HL, Meijboom LJ, Vlaar APJ, Heunks L, Nossent EJ, van der Poll T, Bos LDJ, Duitman J; ArtDECO consortium and the Amsterdam UMC COVID study group. Zhang S, et al. Among authors: van der poll t. Am J Physiol Lung Cell Mol Physiol. 2024 Jan 1;326(1):L7-L18. doi: 10.1152/ajplung.00156.2023. Epub 2023 Nov 7. Am J Physiol Lung Cell Mol Physiol. 2024. PMID: 37933449 Free article.

120

Non-conventional immunomodulation in the management of sepsis.

Slim MA, Turgman O, van Vught LA, van der Poll T, Wiersinga WJ. Slim MA, et al. Among authors: wiersinga wj. Eur J Intern Med. 2024 Mar;121:9-16. doi: 10.1016/j.ejim.2023.10.032. Epub 2023 Oct 31. Eur J Intern Med. 2024. PMID: 37919123 Free article. Review.

121

The safety and efficacy of stem cells for the treatment of severe community-acquired bacterial pneumonia: A randomized clinical trial.

Laterre PF, Sánchez García M, van der Poll T, Wittebole X, Martínez-Sagasti F, Hernandez G, Ferrer R, Caballero J, Cadogan KA, Sullivan A, Zhang B, de la Rosa O, Lombardo E, François B; SEPCELL Study Group. Laterre PF, et al. Among authors: van der poll t. J Crit Care. 2024 Feb;79:154446. doi: 10.1016/j.jcrc.2023.154446. Epub 2023 Oct 31. J Crit Care. 2024. PMID: 37918129 Free article. Clinical Trial.

122

Correction: Plasma protein biomarkers reflective of the host response in patients developing Intensive Care Unit-acquired pneumonia.

van Engelen TSR, Reijnders TDY, Paling FP, Bonten MJM, Timbermont L, Malhotra-Kumar S, Kluytmans JAJW, Peters-Sengers H, van der Poll T; ASPIRE-I. C. U. Study Team. van Engelen TSR, et al. Among authors: van der poll t. Crit Care. 2023 Nov 1;27(1):420. doi: 10.1186/s13054-023-04700-6. Crit Care. 2023. PMID: 37915039 Free PMC article. No abstract available.

123

Myeloid miR-155 plays a limited role in antibacterial defense during Klebsiella-derived pneumosepsis and is dispensable for lipopolysaccharide- or Klebsiella-induced inflammation in mice.

Qin W, Saris A, van 't Veer C, Roelofs JJTH, Scicluna BP, de Vos AF, van der Poll T. Qin W, et al. Among authors: scicluna bp, van t veer c, van der poll t, de vos af. Pathog Dis. 2023 Jan 17;81:ftad031. doi: 10.1093/femspd/ftad031. Pathog Dis. 2023. PMID: 37858304 Free PMC article.

124

Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes.

van Amstel RBE, Kennedy JN, Scicluna BP, Bos LDJ, Peters-Sengers H, Butler JM, Cano-Gamez E, Knight JC, Vlaar APJ, Cremer OL, Angus DC, van der Poll T, Seymour CW, van Vught LA; MARS Consortium. van Amstel RBE, et al. Among authors: scicluna bp, van der poll t. Intensive Care Med. 2023 Nov;49(11):1360-1369. doi: 10.1007/s00134-023-07239-w. Epub 2023 Oct 18. Intensive Care Med. 2023. PMID: 37851064 Free PMC article.

125

Synthesis and Evaluation of Glycosyl Luciferins.

Sondag D, de Kleijne FFJ, Castermans S, Chatzakis I, van Geffen M, Van't Veer C, van Heerde WL, Boltje TJ, Rutjes FPJT. Sondag D, et al. Among authors: van t veer c. Chemistry. 2024 Jan 11;30(3):e202302547. doi: 10.1002/chem.202302547. Epub 2023 Nov 27. Chemistry. 2024. PMID: 37849395

126

Clinical Trial: Probiotics in Metformin Intolerant Patients with Type 2 Diabetes (ProGasMet).

Nabrdalik K, Drożdż K, Kwiendacz H, Skonieczna-Żydecka K, Łoniewski I, Kaczmarczyk M, Wijata AM, Nalepa J, Holleman F, Nieuwdorp M, Gumprecht J. Nabrdalik K, et al. Among authors: holleman f. Biomed Pharmacother. 2023 Dec;168:115650. doi: 10.1016/j.biopha.2023.115650. Epub 2023 Oct 7. Biomed Pharmacother. 2023. PMID: 37812890 Free article. Clinical Trial.

127

Burkholderia pseudomallei and melioidosis.

Meumann EM, Limmathurotsakul D, Dunachie SJ, Wiersinga WJ, Currie BJ. Meumann EM, et al. Among authors: wiersinga wj. Nat Rev Microbiol. 2024 Mar;22(3):155-169. doi: 10.1038/s41579-023-00972-5. Epub 2023 Oct 4. Nat Rev Microbiol. 2024. PMID: 37794173 Review.

128

Detecting changes in the performance of a clinical machine learning tool over time.

Schinkel M, Boerman AW, Paranjape K, Wiersinga WJ, Nanayakkara PWB. Schinkel M, et al. Among authors: nanayakkara pwb, wiersinga wj. EBioMedicine. 2023 Nov;97:104823. doi: 10.1016/j.ebiom.2023.104823. Epub 2023 Oct 2. EBioMedicine. 2023. PMID: 37793210 Free PMC article.

129

High-dimensional analysis reveals an immune atlas and novel neutrophil clusters in the lungs of model animals with Actinobacillus pleuropneumoniae-induced pneumonia.

Li N, Zhu J, Chen P, Bao C, Wang J, Abdelaal T, Chen D, Zhu S, Wang W, Mao J, Scicluna BP, Koning F, Li F, Lei L. Li N, et al. Among authors: scicluna bp. Vet Res. 2023 Sep 13;54(1):76. doi: 10.1186/s13567-023-01207-4. Vet Res. 2023. PMID: 37705063 Free PMC article.

130

A Graphical Overview of the Histopathology of Human Melioidosis: A Case Series.

Savelkoel J, Tiemensma M, Birnie E, Wiersinga WJ, Currie BJ, Roelofs JJTH. Savelkoel J, et al. Among authors: wiersinga wj. Open Forum Infect Dis. 2023 Jul 12;10(8):ofad367. doi: 10.1093/ofid/ofad367. eCollection 2023 Aug. Open Forum Infect Dis. 2023. PMID: 37547853 Free PMC article.

131

Thrombocytopenia is associated with a dysregulated host response in severe COVID-19.

Appelman B, Michels EHA, de Brabander J, Peters-Sengers H, van Amstel RBE, Noordzij SM, Klarenbeek AM, van Linge CCA, Chouchane O, Schuurman AR, Reijnders TDY, Douma RA, Bos LDJ; Amsterdam UMC COVID-19 Biobank study group; CovidPredict study group; Wiersinga WJ, van der Poll T. Appelman B, et al. Among authors: wiersinga wj, van der poll t. Thromb Res. 2023 Sep;229:187-197. doi: 10.1016/j.thromres.2023.07.008. Epub 2023 Jul 19. Thromb Res. 2023. PMID: 37541167 Free article.

132

Residual β-Cell Function Is Associated With Longer Time in Range in Individuals With Type 1 Diabetes.

Fuhri Snethlage CM, McDonald TJ, Oram RD, de Groen P, Rampanelli E, Schimmel AWM, Holleman F, Siegelaar S, Hoekstra J, Brouwer CB, Knop FK, Verchere CB, van Raalte DH, Roep BO, Nieuwdorp M, Hanssen NMJ. Fuhri Snethlage CM, et al. Among authors: holleman f. Diabetes Care. 2024 Jul 1;47(7):1114-1121. doi: 10.2337/dc23-0776. Diabetes Care. 2024. PMID: 37535870 Free PMC article.

133

Inflammatory and glycolytic programs underpin a primed blood neutrophil state in patients with pneumonia.

Schuurman AR, Butler JM, Michels EHA, Otto NA, Brands X, Haak BW, Uhel F, Klarenbeek AM, Faber DR, Schomakers BV, van Weeghel M, de Vos AF, Scicluna BP, Houtkooper RH, Wiersinga WJ, van der Poll T. Schuurman AR, et al. Among authors: scicluna bp, wiersinga wj, van der poll t, de vos af. iScience. 2023 Jun 19;26(7):107181. doi: 10.1016/j.isci.2023.107181. eCollection 2023 Jul 21. iScience. 2023. PMID: 37496676 Free PMC article.

134

Plasma protein biomarkers reflective of the host response in patients developing Intensive Care Unit-acquired pneumonia.

van Engelen TSR, Reijnders TDY, Paling FP, Bonten MJM, Timbermont L, Malhotra-Kumar S, Kluytmans JAJW, Peters-Sengers H, van der Poll T; ASPIRE-I. C. U. Study Team. van Engelen TSR, et al. Among authors: van der poll t. Crit Care. 2023 Jul 6;27(1):269. doi: 10.1186/s13054-023-04536-0. Crit Care. 2023. PMID: 37415223 Free PMC article.

135

Health Outcomes and Cost-effectiveness of Monoclonal SARS-CoV-2 Antibodies as Pre-exposure Prophylaxis.

Popping S, Nichols BE, Appelman B, Biemond JJ, Vergouwe M, Rosendaal FR, van der Valk M, de Bree GJ, Wiersinga WJ, Birnie E; TURN-COVID study group. Popping S, et al. Among authors: wiersinga wj. JAMA Netw Open. 2023 Jul 3;6(7):e2321985. doi: 10.1001/jamanetworkopen.2023.21985. JAMA Netw Open. 2023. PMID: 37410460 Free PMC article.

136

[Take a seat when talking with a patient].

van Galen LS, Prince KJAH, Nanayakkara PW. van Galen LS, et al. Among authors: nanayakkara pw. Ned Tijdschr Geneeskd. 2023 Jun 14;167:D7475. Ned Tijdschr Geneeskd. 2023. PMID: 37345619 Review. Dutch.

137

Selective digestive decontamination- Not sure.

Wiersinga WJ. Wiersinga WJ. Intensive Care Med. 2023 Aug;49(8):984-986. doi: 10.1007/s00134-023-07115-7. Epub 2023 Jun 19. Intensive Care Med. 2023. PMID: 37336865 No abstract available.

138

Differences in incidence, nature of symptoms, and duration of long COVID among hospitalised migrant and non-migrant patients in the Netherlands: a retrospective cohort study.

Chilunga FP, Appelman B, van Vugt M, Kalverda K, Smeele P, van Es J, Wiersinga WJ, Rostila M, Prins M, Stronks K, Norredam M, Agyemang C. Chilunga FP, et al. Among authors: wiersinga wj. Lancet Reg Health Eur. 2023 Apr 7;29:100630. doi: 10.1016/j.lanepe.2023.100630. eCollection 2023 Jun. Lancet Reg Health Eur. 2023. PMID: 37261215 Free PMC article.

139

Embracing cohort heterogeneity in clinical machine learning development: a step toward generalizable models.

Schinkel M, Bennis FC, Boerman AW, Wiersinga WJ, Nanayakkara PWB. Schinkel M, et al. Among authors: nanayakkara pwb, wiersinga wj. Sci Rep. 2023 May 24;13(1):8363. doi: 10.1038/s41598-023-35557-y. Sci Rep. 2023. PMID: 37225751 Free PMC article.

140

Empiric anti-anaerobic antibiotics are associated with adverse clinical outcomes in emergency department patients.

Kullberg RFJ, Schinkel M, Wiersinga WJ. Kullberg RFJ, et al. Among authors: wiersinga wj. Eur Respir J. 2023 May 11;61(5):2300413. doi: 10.1183/13993003.00413-2023. Print 2023 May. Eur Respir J. 2023. PMID: 37169379 Free article. No abstract available.

141

Leaving the hospital on time: hospital bed utilization and reasons for discharge delay in the Netherlands.

van den Ende E, Schouten B, Pladet L, Merten H, van Galen L, Marinova M, Schinkel M, Boerman AW, Nannan Panday R, Rustemeijer C, Dulaimy M, Bell D, Nanayakkara PW. van den Ende E, et al. Among authors: nanayakkara pw. Int J Qual Health Care. 2023 May 13;35(2):mzad022. doi: 10.1093/intqhc/mzad022. Int J Qual Health Care. 2023. PMID: 37148301 Free PMC article.

142

Outcomes of community-acquired pneumonia using the Pneumonia Severity Index versus the CURB-65 in routine practice of emergency departments.

Kaal AG, Op de Hoek L, Hochheimer DT, Brouwers C, Wiersinga WJ, Snijders D, Rensing KL, van Dijk CE, Steyerberg EW, van Nieuwkoop C. Kaal AG, et al. Among authors: wiersinga wj. ERJ Open Res. 2023 May 2;9(3):00051-2023. doi: 10.1183/23120541.00051-2023. eCollection 2023 Jul. ERJ Open Res. 2023. PMID: 37143846 Free PMC article.

143

Persistent alveolar inflammatory response in critically ill patients with COVID-19 is associated with mortality.

de Brabander J, Boers LS, Kullberg RFJ, Zhang S, Nossent EJ, Heunks LMA, Vlaar APJ, Bonta PI, Schultz MJ, van der Poll T, Duitman J, Bos LDJ; ArtDECO consortium; Amsterdam UMC COVID Study group; BASIC consortium; Amsterdam UMC COVID study group. de Brabander J, et al. Among authors: van der poll t. Thorax. 2023 Sep;78(9):912-921. doi: 10.1136/thorax-2023-219989. Epub 2023 May 4. Thorax. 2023. PMID: 37142421

144

Presence of Burkholderia pseudomallei in Soil, Nigeria, 2019.

Savelkoel J, Oladele RO, Ojide CK, Peters RF, Notermans DW, Makinwa JO, de Vries MC, Sunter MAE, Matamoros S, Abdullahi N, Unigwe US, Akanmu AS, Wiersinga WJ, Birnie E. Savelkoel J, et al. Among authors: wiersinga wj. Emerg Infect Dis. 2023 May;29(5):1073-1075. doi: 10.3201/eid2905.221138. Emerg Infect Dis. 2023. PMID: 37081606 Free PMC article.

145

Age-related changes in plasma biomarkers and their association with mortality in COVID-19.

Michels EHA, Appelman B, de Brabander J, van Amstel RBE, Chouchane O, van Linge CCA, Schuurman AR, Reijnders TDY, Sulzer TAL, Klarenbeek AM, Douma RA; Amsterdam UMC COVID-19 Biobank Study Group; Bos LDJ, Wiersinga WJ, Peters-Sengers H, van der Poll T; Amsterdam UMC COVID-19 Biobank Study Group; van Agtmael M, Algera AG, Appelman B, van Baarle F, Beudel M, Bogaard HJ, Bomers M, Bonta P, Bos L, Botta M, de Brabander J, de Bree G, de Bruin S, Bugiani M, Bulle E, Buis DTP, Chouchane O, Cloherty A, Dijkstra M, Dongelmans DA, Dujardin RWG, Elbers P, Fleuren L, Geerlings S, Geijtenbeek T, Girbes A, Goorhuis B, Grobusch MP, Hagens L, Hamann J, Harris V, Hemke R, Hermans SM, Heunks L, Hollmann M, Horn J, Hovius JW, de Jong HK, de Jong MD, Koning R, Lemkes B, Lim EHT, van Mourik N, Nellen J, Nossent EJ, Olie S, Paulus F, Peters E, Pina-Fuentes DAI, van der Poll T, Preckel B, Prins JM, Raasveld J, Reijnders T, de Rotte MCFJ, Schinkel M, Schultz MJ, Schrauwen FAP, Schuurman A, Schuurmans J, Sigaloff K, Slim MA, Smeele P, Smit M, Stijnis CS, Stilma W, Teunissen C, Thoral P, Tsonas AM, Tuinman PR, van der Valk M, Veelo DP, Volleman C, de Vries H, Vught LA, van Vugt M, Woute… See abstract for full author list ➔ Michels EHA, et al. Among authors: wiersinga wj, van der poll t. Eur Respir J. 2023 Jul 7;62(1):2300011. doi: 10.1183/13993003.00011-2023. Print 2023 Jul. Eur Respir J. 2023. PMID: 37080568 Free PMC article.

146

[Can artificial intelligence write a medical-scientific article of sufficient quality?].

Schuurman AR, Schinkel M, de Kreij S, Wiersinga WJ. Schuurman AR, et al. Among authors: wiersinga wj. Ned Tijdschr Geneeskd. 2023 Apr 12;167:D7496. Ned Tijdschr Geneeskd. 2023. PMID: 37052399 Dutch.

147

Older patients with nonspecific complaints at the Emergency Department are at risk of adverse health outcomes.

van Dam CS, Peters MJL, Hoogendijk EO, Nanayakkara PWB, Muller M, Trappenburg MC. van Dam CS, et al. Among authors: nanayakkara pwb. Eur J Intern Med. 2023 Jun;112:86-92. doi: 10.1016/j.ejim.2023.03.018. Epub 2023 Mar 29. Eur J Intern Med. 2023. PMID: 37002150 Free article.

148

A Changed Gut Microbiota Diversity Is Associated With Metabolic Improvements After Duodenal Mucosal Resurfacing With Glucagon-Like-Peptide-1 Receptor Agonist in Type 2 Diabetes in a Pilot Study.

Meiring S, van Baar ACG, Sørensen N, Holleman F, Soeters MR, Nieuwdorp M, Bergman JJGHM. Meiring S, et al. Among authors: holleman f. Front Clin Diabetes Healthc. 2022 Jul 5;3:856661. doi: 10.3389/fcdhc.2022.856661. eCollection 2022. Front Clin Diabetes Healthc. 2022. PMID: 36992788 Free PMC article.

149

Host Response Biomarkers for Sepsis in the Emergency Room.

Turgman O, Schinkel M, Wiersinga WJ. Turgman O, et al. Among authors: wiersinga wj. Crit Care. 2023 Mar 21;27(1):97. doi: 10.1186/s13054-023-04367-z. Crit Care. 2023. PMID: 36941681 Free PMC article. Review.

150

Embracing complexity in sepsis.

Schuurman AR, Sloot PMA, Wiersinga WJ, van der Poll T. Schuurman AR, et al. Among authors: wiersinga wj, van der poll t. Crit Care. 2023 Mar 11;27(1):102. doi: 10.1186/s13054-023-04374-0. Crit Care. 2023. PMID: 36906606 Free PMC article. Review.

151

Prophylactic and early outpatient treatment of COVID-19 in patients with kidney disease: considerations from the Immunonephrology Working Group of the European Renal Association (ERA-IWG).

Hilhorst M, Bemelman FJ, Bruchfeld A, Fernandez-Juarez GM, Floege J, Frangou E, Goumenos D, van Kooten C, Kronbichler A, Stevens KI, Turkmen K, Wiersinga WJ, Anders HJ. Hilhorst M, et al. Among authors: wiersinga wj. Nephrol Dial Transplant. 2023 Jul 31;38(8):1807-1816. doi: 10.1093/ndt/gfad044. Nephrol Dial Transplant. 2023. PMID: 36881727

152

The power of the gut in critical care.

Wiersinga WJ. Wiersinga WJ. Curr Opin Crit Care. 2023 Apr 1;29(2):99-100. doi: 10.1097/MCC.0000000000001014. Curr Opin Crit Care. 2023. PMID: 36880557 No abstract available.

153

THE EUROPEAN SHOCK SOCIETY MEETS THE IMMUNOSEP CONSORTIUM FOR PERSONALIZED SEPSIS TREATMENT.

Giamarellos-Bourboulis EJ, Dimopoulos G, Flohé S, Kotsaki A, van der Poll T, Skirecki T, Torres A, Netea MG. Giamarellos-Bourboulis EJ, et al. Among authors: van der poll t. Shock. 2023 Mar 1;59(3S Suppl 1):21-25. doi: 10.1097/SHK.0000000000001955. Epub 2022 Jul 24. Shock. 2023. PMID: 36867758

154

Monitoring of pulmonary involvement in critically ill COVID-19 patients - should lung ultrasound be preferred over CT?

Lieveld AWE, Heldeweg MLA, Schouwenburg J, Veldhuis L, Haaksma ME, van Haaften RM, Teunissen BP, Smit JM, Twisk J, Heunks L, Nanayakkara PWB, Tuinman PR. Lieveld AWE, et al. Among authors: nanayakkara pwb. Ultrasound J. 2023 Feb 26;15(1):11. doi: 10.1186/s13089-022-00299-x. Ultrasound J. 2023. PMID: 36842163 Free PMC article.

155

No evidence for relevant impact of renal replacement therapy on clinical effect of erythromycin in critically ill patients with sepsis.

Reijnders TDY, Peters-Sengers H, van der Poll T. Reijnders TDY, et al. Among authors: van der poll t. Crit Care. 2023 Feb 23;27(1):70. doi: 10.1186/s13054-023-04359-z. Crit Care. 2023. PMID: 36823610 Free PMC article. No abstract available.

156

Artificial Intelligence for Early Sepsis Detection: A Word of Caution.

Schinkel M, van der Poll T, Wiersinga WJ. Schinkel M, et al. Among authors: wiersinga wj, van der poll t. Am J Respir Crit Care Med. 2023 Apr 1;207(7):853-854. doi: 10.1164/rccm.202212-2284VP. Am J Respir Crit Care Med. 2023. PMID: 36724366 Free PMC article. No abstract available.

157

ImmunoSep (Personalised Immunotherapy in Sepsis) international double-blind, double-dummy, placebo-controlled randomised clinical trial: study protocol.

Kotsaki A, Pickkers P, Bauer M, Calandra T, Lupse M, Wiersinga WJ, Meylan S, Bloos F, van der Poll T, Slim MA, van Mourik N, Müller MCA, van Vught L, Vlaar APJ, de Nooijer A, Bakkerus L, Weis S, Antonakos N, Netea MG, Giamarellos-Bourboulis EJ. Kotsaki A, et al. Among authors: wiersinga wj, van der poll t. BMJ Open. 2022 Dec 20;12(12):e067251. doi: 10.1136/bmjopen-2022-067251. BMJ Open. 2022. PMID: 36600424 Free PMC article.

158

Digital disparities among healthcare workers in typing speed between generations, genders, and medical specialties: cross sectional study.

Schuurman AR, Baarsma ME, Wiersinga WJ, Hovius JW. Schuurman AR, et al. Among authors: wiersinga wj. BMJ. 2022 Dec 19;379:e072784. doi: 10.1136/bmj-2022-072784. BMJ. 2022. PMID: 36535672 Free PMC article.

159

Role of Hypoxia-inducible factor 1α in host defense during pneumococcal pneumonia.

Pereverzeva L, Otto NA, Peters-Sengers H, Roelofs JJTH, de Vos AF, van der Poll T. Pereverzeva L, et al. Among authors: van der poll t, de vos af. Pathog Dis. 2023 Jan 17;81:ftac047. doi: 10.1093/femspd/ftac047. Pathog Dis. 2023. PMID: 36535641

160

The usefulness of implementing minimum retest intervals in reducing inappropriate laboratory test requests in a Dutch hospital.

Boerman AW, Al-Dulaimy M, Bandt YC, Nanayakkara PWB, de Jonge R. Boerman AW, et al. Among authors: nanayakkara pwb. Clin Chem Lab Med. 2022 Dec 19;61(3):412-418. doi: 10.1515/cclm-2022-0946. Print 2023 Feb 23. Clin Chem Lab Med. 2022. PMID: 36525643 Free article.

161

Real-world Evidence of the Effects of Novel Treatments for COVID-19 on Mortality: A Nationwide Comparative Cohort Study of Hospitalized Patients in the First, Second, Third, and Fourth Waves in the Netherlands.

Slim MA, Appelman B, Peters-Sengers H, Dongelmans DA, de Keizer NF, Schade RP, de Boer MGJ, Müller MCA, Vlaar APJ, Wiersinga WJ, van Vught LA; NICE COVID-19 Research Consortium and the COVIDPredict study group. Slim MA, et al. Among authors: wiersinga wj. Open Forum Infect Dis. 2022 Nov 22;9(12):ofac632. doi: 10.1093/ofid/ofac632. eCollection 2022 Dec. Open Forum Infect Dis. 2022. PMID: 36519114 Free PMC article.

162

Association between age and the host response in critically ill patients with sepsis.

Michels EHA, Butler JM, Reijnders TDY, Cremer OL, Scicluna BP, Uhel F, Peters-Sengers H, Schultz MJ, Knight JC, van Vught LA, van der Poll T; MARS consortium. Michels EHA, et al. Among authors: scicluna bp, van der poll t. Crit Care. 2022 Dec 13;26(1):385. doi: 10.1186/s13054-022-04266-9. Crit Care. 2022. PMID: 36514130 Free PMC article.

163

Immunopathophysiology of human sepsis.

Wiersinga WJ, van der Poll T. Wiersinga WJ, et al. Among authors: van der poll t. EBioMedicine. 2022 Dec;86:104363. doi: 10.1016/j.ebiom.2022.104363. Epub 2022 Dec 2. EBioMedicine. 2022. PMID: 36470832 Free PMC article. Review.

164

Good Bug, Bad Bug: What Is Influencing the Fever Response during Infection?

Kullberg RFJ, Wiersinga WJ. Kullberg RFJ, et al. Among authors: wiersinga wj. Am J Respir Crit Care Med. 2023 Apr 15;207(8):967-969. doi: 10.1164/rccm.202211-2170ED. Am J Respir Crit Care Med. 2023. PMID: 36470241 Free PMC article. No abstract available.

165

SEVERE CORONAVIRUS DISEASE 2019: FROM PATHOGENESIS TO THERAPY.

Cavaillon JM, Artigas A, Barratt-Due A, Giamarellos-Bourboulis EJ, Gómez H, Hayem G, Vlaar APJ, Wiersinga WJ. Cavaillon JM, et al. Among authors: wiersinga wj. Shock. 2023 Mar 1;59(3S Suppl 1):10-15. doi: 10.1097/SHK.0000000000001956. Epub 2022 Jul 24. Shock. 2023. PMID: 36469709

166

Glucose metabolism is upregulated in the mononuclear cell proteome during sepsis and supports endotoxin-tolerant cell function.

Ferreira BL, Sousa MB, Leite GGF, Brunialti MKC, Nishiduka ES, Tashima AK, van der Poll T, Salomão R. Ferreira BL, et al. Among authors: van der poll t. Front Immunol. 2022 Nov 18;13:1051514. doi: 10.3389/fimmu.2022.1051514. eCollection 2022. Front Immunol. 2022. PMID: 36466921 Free PMC article.

167

Significant impact of vaccination on length of hospital stay and survival in hospitalized patients with COVID-19.

Leuning DG, Groeneveld GH, Appelman B, Wiersinga WJ, de Boer MGJ. Leuning DG, et al. Among authors: wiersinga wj. New Microbes New Infect. 2022 Nov-Dec;49:101047. doi: 10.1016/j.nmni.2022.101047. Epub 2022 Nov 21. New Microbes New Infect. 2022. PMID: 36440092 Free PMC article. No abstract available.

168

Sleep in hospitalized pediatric and adult patients - A systematic review and meta-analysis.

Burger P, Van den Ende ES, Lukman W, Burchell GL, Steur LMH, Merten H, Nanayakkara PWB, Gemke RJBJ. Burger P, et al. Among authors: nanayakkara pwb. Sleep Med X. 2022 Nov 5;4:100059. doi: 10.1016/j.sleepx.2022.100059. eCollection 2022 Dec. Sleep Med X. 2022. PMID: 36406659 Free PMC article.

169

In reply to: 'Use TRIPOD when validating clinical prediction models'.

Schinkel M, Holleman F. Schinkel M, et al. Among authors: holleman f. Emerg Med J. 2023 Jan;40(1):81-82. doi: 10.1136/emermed-2022-212701. Epub 2022 Nov 17. Emerg Med J. 2023. PMID: 36396346 No abstract available.

170

The impact of a sepsis performance improvement program in the emergency department: a before-after intervention study.

Schinkel M, Holleman F, Vleghels R, Brugman K, Ridderikhof ML, Dzelili M, Nanayakkara PWB, Wiersinga WJ. Schinkel M, et al. Among authors: nanayakkara pwb, wiersinga wj, holleman f. Infection. 2023 Aug;51(4):945-954. doi: 10.1007/s15010-022-01957-x. Epub 2022 Nov 17. Infection. 2023. PMID: 36394818 Free PMC article.

171

Use of the National Early Warning Score for predicting deterioration of patients with acute pulmonary embolism: a post-hoc analysis of the YEARS Study.

Bavalia R, Stals MAM, Mulder FI, Bistervels IM, Coppens M, Faber LM, Hendriks SV, Hofstee HMA, Huisman MV, van der Hulle T, Mairuhu ATA, Kruip MJHA, Middeldorp S, Klok FA, Hutten BA, Holleman F. Bavalia R, et al. Among authors: holleman f. Emerg Med J. 2023 Jan;40(1):61-66. doi: 10.1136/emermed-2021-211506. Epub 2022 Nov 7. Emerg Med J. 2023. PMID: 36344240

172

An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression.

Cano-Gamez E, Burnham KL, Goh C, Allcock A, Malick ZH, Overend L, Kwok A, Smith DA, Peters-Sengers H, Antcliffe D; GAinS Investigators; McKechnie S, Scicluna BP, van der Poll T, Gordon AC, Hinds CJ, Davenport EE, Knight JC, Webster N, Galley H, Taylor J, Hall S, Addison J, Roughton S, Tennant H, Guleri A, Waddington N, Arawwawala D, Durcan J, Short A, Swan K, Williams S, Smolen S, Mitchell-Inwang C, Gordon T, Errington E, Templeton M, Venatesh P, Ward G, McCauley M, Baudouin S, Higham C, Soar J, Grier S, Hall E, Brett S, Kitson D, Wilson R, Mountford L, Moreno J, Hall P, Hewlett J, McKechnie S, Garrard C, Millo J, Young D, Hutton P, Parsons P, Smiths A, Faras-Arraya R, Soar J, Raymode P, Thompson J, Bowrey S, Kazembe S, Rich N, Andreou P, Hales D, Roberts E, Fletcher S, Rosbergen M, Glister G, Cuesta JM, Bion J, Millar J, Perry EJ, Willis H, Mitchell N, Ruel S, Carrera R, Wilde J, Nilson A, Lees S, Kapila A, Jacques N, Atkinson J, Brown A, Prowse H, Krige A, Bland M, Bullock L, Harrison D, Mills G, Humphreys J, Armitage K, Laha S, Baldwin J, Walsh A, Doherty N, Drage S, Ortiz-Ruiz de Gordoa L, Lowes S, Higham C, Walsh H, Calder V, Swan C, Payne H, Higgins D, Andrews … See abstract for full author list ➔ Cano-Gamez E, et al. Among authors: scicluna bp, van der poll t. Sci Transl Med. 2022 Nov 2;14(669):eabq4433. doi: 10.1126/scitranslmed.abq4433. Epub 2022 Nov 2. Sci Transl Med. 2022. PMID: 36322631 Free PMC article.

173

Recreational Drug Use During the Amsterdam Dance Event: Impact on Emergency Services.

Gresnigt FM, Ghaem Maghami P, van Exter P, Noordhoff A, van Dijk T, van Litsenburg R, Holleman F, Kramer MH, Nanayakkara PW. Gresnigt FM, et al. Among authors: nanayakkara pw, holleman f. Subst Abuse. 2022 Oct 19;16:11782218221114965. doi: 10.1177/11782218221114965. eCollection 2022. Subst Abuse. 2022. PMID: 36312590 Free PMC article.

174

Microglial response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice after systemic stimulation with Escherichia coli.

Hoogland ICM, Yik J, Westhoff D, Engelen-Lee JY, Valls Seron M, Man WK, Houben-Weerts JHPM, Tanck MW, van Westerloo DJ, van der Poll T, van Gool WA, van de Beek D. Hoogland ICM, et al. Among authors: van der poll t. Neurosci Lett. 2022 Nov 1;790:136894. doi: 10.1016/j.neulet.2022.136894. Epub 2022 Sep 29. Neurosci Lett. 2022. PMID: 36183964 Free article.

175

The End of "One Size Fits All" Sepsis Therapies: Toward an Individualized Approach.

Vincent JL, van der Poll T, Marshall JC. Vincent JL, et al. Among authors: van der poll t. Biomedicines. 2022 Sep 12;10(9):2260. doi: 10.3390/biomedicines10092260. Biomedicines. 2022. PMID: 36140361 Free PMC article. Review.

176

Evaluation of Nonpharmacologic Interventions and Sleep Outcomes in Hospitalized Medical and Surgical Patients: A Nonrandomized Controlled Trial.

van den Ende ES, Merten H, Van der Roest L, Toussaint B, van Rijn Q, Keesenberg M, Lodders AM, van Veldhuizen K, Vos IE, Hoekstra S, Nanayakkara PWB. van den Ende ES, et al. Among authors: nanayakkara pwb. JAMA Netw Open. 2022 Sep 1;5(9):e2232623. doi: 10.1001/jamanetworkopen.2022.32623. JAMA Netw Open. 2022. PMID: 36129708 Free PMC article. Clinical Trial.

177

Author Correction: Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment.

Mills JD, Iyer AM, van Scheppingen J, Bongaarts A, Anink JJ, Janssen B, Zimmer TS, Spliet WG, van Rijen PC, Jansen FE, Feucht M, Hainfellner JA, Krsek P, Zamecnik J, Kotulska K, Jozwiak S, Jansen A, Lagae L, Curatolo P, Kwiatkowski DJ, Pasterkamp RJ, Senthilkumar K, von Oerthel L, Hoekman MF, Gorter JA, Crino PB, Mühlebner A, Scicluna BP, Aronica E. Mills JD, et al. Among authors: scicluna bp. Sci Rep. 2022 Sep 14;12(1):15457. doi: 10.1038/s41598-022-20109-7. Sci Rep. 2022. PMID: 36104396 Free PMC article. No abstract available.

178

Myeloid liver kinase B1 contributes to lung inflammation induced by lipoteichoic acid but not by viable Streptococcus pneumoniae.

Pereverzeva L, Otto NA, Roelofs JJTH, de Vos AF, van der Poll T. Pereverzeva L, et al. Among authors: van der poll t, de vos af. Respir Res. 2022 Sep 12;23(1):241. doi: 10.1186/s12931-022-02168-6. Respir Res. 2022. PMID: 36096803 Free PMC article.

179

Artificial Intelligence for the Prediction of In-Hospital Clinical Deterioration: A Systematic Review.

Veldhuis LI, Woittiez NJC, Nanayakkara PWB, Ludikhuize J. Veldhuis LI, et al. Among authors: nanayakkara pwb. Crit Care Explor. 2022 Aug 26;4(9):e0744. doi: 10.1097/CCE.0000000000000744. eCollection 2022 Sep. Crit Care Explor. 2022. PMID: 36046062 Free PMC article. Review.

180

The Azithromycin Pro-Drug CSY5669 Boosts Bacterial Killing While Attenuating Lung Inflammation Associated with Pneumonia Caused by Methicillin-Resistant Staphylococcus aureus.

Saris A, Qin W, van Linge CCA, Reijnders TDY, Florquin S, Burnet M, Strass S, de Vos AF, van der Poll T. Saris A, et al. Among authors: van der poll t, de vos af. Antimicrob Agents Chemother. 2022 Sep 20;66(9):e0229821. doi: 10.1128/aac.02298-21. Epub 2022 Aug 16. Antimicrob Agents Chemother. 2022. PMID: 35972289 Free PMC article.

181

Intracellular pyruvate levels positively correlate with cytokine production capacity in tolerant monocytes from patients with pneumonia.

Otto NA, Butler JM, Schuurman AR, Brands X, Haak BW, Klarenbeek AM, van Weeghel M, Houtkooper RH, Jakobs ME, Faber DR, de Vos AF, Wiersinga WJ, Scicluna BP, van der Poll T. Otto NA, et al. Among authors: scicluna bp, wiersinga wj, van der poll t, de vos af. Biochim Biophys Acta Mol Basis Dis. 2022 Nov 1;1868(11):166519. doi: 10.1016/j.bbadis.2022.166519. Epub 2022 Aug 12. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35964875 Free article.

182

The 2021 Dutch Working Party on Antibiotic Policy (SWAB) guidelines for empirical antibacterial therapy of sepsis in adults.

Sieswerda E, Bax HI, Hoogerwerf JJ, de Boer MGJ, Boermeester M, Bonten MJM, Dekker D, van Wijk RG, Juffermans NP, Kuindersma M, van der Linden PD, Melles DC, Pickkers P, Schouten JA, Rebel JR, van Zanten ARH, Prins JM, Wiersinga WJ. Sieswerda E, et al. Among authors: wiersinga wj. BMC Infect Dis. 2022 Aug 11;22(1):687. doi: 10.1186/s12879-022-07653-3. BMC Infect Dis. 2022. PMID: 35953772 Free PMC article.

183

Performance of early warning and risk stratification scores versus clinical judgement in the acute setting: a systematic review.

Veldhuis LI, Ridderikhof ML, Bergsma L, Van Etten-Jamaludin F, Nanayakkara PW, Hollmann M. Veldhuis LI, et al. Among authors: nanayakkara pw. Emerg Med J. 2022 Dec;39(12):918-923. doi: 10.1136/emermed-2021-211524. Epub 2022 Aug 9. Emerg Med J. 2022. PMID: 35944968

184

Rectal microbiota are coupled with altered cytokine production capacity following community-acquired pneumonia hospitalization.

Kullberg RFJ, Brands X, Klarenbeek AM, Butler JM, Otto NA, Faber DR, Scicluna BP, van der Poll T, Wiersinga WJ, Haak BW. Kullberg RFJ, et al. Among authors: scicluna bp, wiersinga wj, van der poll t. iScience. 2022 Jul 14;25(8):104740. doi: 10.1016/j.isci.2022.104740. eCollection 2022 Aug 19. iScience. 2022. PMID: 35938048 Free PMC article.

185

Patients with hypothermic sepsis have a unique gene expression profile compared to patients with fever and sepsis.

Harmon MBA, Scicluna BP, Wiewel MA, Schultz MJ, Horn J, Cremer OL, van der Poll T, Joost Wiersinga W, Juffermans NP; MARS consortium. Harmon MBA, et al. Among authors: scicluna bp, van der poll t. J Cell Mol Med. 2022 Apr;26(7):1896-1904. doi: 10.1111/jcmm.17156. Epub 2022 Mar 1. J Cell Mol Med. 2022. PMID: 35934940 Free PMC article.

186

Development of Resistance-Associated Mutations After Sotrovimab Administration in High-risk Individuals Infected With the SARS-CoV-2 Omicron Variant.

Birnie E, Biemond JJ, Appelman B, de Bree GJ, Jonges M, Welkers MRA, Wiersinga WJ. Birnie E, et al. Among authors: wiersinga wj. JAMA. 2022 Sep 20;328(11):1104-1107. doi: 10.1001/jama.2022.13854. JAMA. 2022. PMID: 35913747 Free PMC article.

187

The Long Non-Coding Antisense RNA JHDM1D-AS1 Regulates Inflammatory Responses in Human Monocytes.

Malmström E, Khan HN, Veer CV', Stunnenberg M, Meijer MT, Matsumoto H, Otto NA, Geijtenbeek TBH, de Vos AF, van der Poll T, Scicluna BP. Malmström E, et al. Among authors: scicluna bp, van der poll t, de vos af. Front Cell Infect Microbiol. 2022 Jul 12;12:934313. doi: 10.3389/fcimb.2022.934313. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35903199 Free PMC article.

188

Immunomodulation and endothelial barrier protection mediate the association between oral imatinib and mortality in hospitalised COVID-19 patients.

de Brabander J, Duijvelaar E, Schippers JR, Smeele PJ, Peters-Sengers H, Duitman JW, Aman J, Bogaard HJ, van der Poll T, Bos LDJ; CounterCOVID Study Group. de Brabander J, et al. Among authors: van der poll t. Eur Respir J. 2022 Dec 15;60(6):2200780. doi: 10.1183/13993003.00780-2022. Print 2022 Dec. Eur Respir J. 2022. PMID: 35896211 Free PMC article. Clinical Trial.

189

Immune suppression is associated with enhanced systemic inflammatory, endothelial and procoagulant responses in critically ill patients.

Brands X, Uhel F, van Vught LA, Wiewel MA, Hoogendijk AJ, Lutter R, Schultz MJ, Scicluna BP, van der Poll T. Brands X, et al. Among authors: scicluna bp, van der poll t. PLoS One. 2022 Jul 25;17(7):e0271637. doi: 10.1371/journal.pone.0271637. eCollection 2022. PLoS One. 2022. PMID: 35877767 Free PMC article.

190

Reply to: Microbial Burden-associated Cytokine Storm May Explain Non-Resolving ARDS in COVID-19 Patients.

Kullberg RFJ, de Brabander J, Boers LS, Bos LDJ, Wiersinga WJ. Kullberg RFJ, et al. Among authors: wiersinga wj. Am J Respir Crit Care Med. 2022 Nov 1;206(9):1183-1184. doi: 10.1164/rccm.202207-1346LE. Am J Respir Crit Care Med. 2022. PMID: 35867884 Free PMC article. No abstract available.

191

Diagnostic stewardship for blood cultures in the emergency department: A multicenter validation and prospective evaluation of a machine learning prediction tool.

Schinkel M, Boerman AW, Bennis FC, Minderhoud TC, Lie M, Peters-Sengers H, Holleman F, Schade RP, de Jonge R, Wiersinga WJ, Nanayakkara PWB. Schinkel M, et al. Among authors: nanayakkara pwb, wiersinga wj, holleman f. EBioMedicine. 2022 Aug;82:104176. doi: 10.1016/j.ebiom.2022.104176. Epub 2022 Jul 16. EBioMedicine. 2022. PMID: 35853298 Free PMC article.

192

The Platelet Lipidome Is Altered in Patients with COVID-19 and Correlates with Platelet Reactivity.

Schuurman AR, Léopold V, Pereverzeva L, Chouchane O, Reijnders TDY, Brabander J, Douma RA, Weeghel MV, Wever E, Schomaker BV, Vaz FM, Wiersinga WJ, Veer CV, Poll TV. Schuurman AR, et al. Among authors: wiersinga wj. Thromb Haemost. 2022 Oct;122(10):1683-1692. doi: 10.1055/s-0042-1749438. Epub 2022 Jul 18. Thromb Haemost. 2022. PMID: 35850149 Free PMC article.

193

Comparison of inhibitory effects of irreversible and reversible Btk inhibitors on platelet function.

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Human alveolar macrophages do not rely on glucose metabolism upon activation by lipopolysaccharide.

Pereverzeva L, van Linge CCA, Schuurman AR, Klarenbeek AM, Ramirez Moral I, Otto NA, Peters-Sengers H, Butler JM, Schomakers BV, van Weeghel M, Houtkooper RH, Wiersinga WJ, Bonta PI, Annema JT, de Vos AF, van der Poll T. Pereverzeva L, et al. Among authors: wiersinga wj, van der poll t, de vos af. Biochim Biophys Acta Mol Basis Dis. 2022 Oct 1;1868(10):166488. doi: 10.1016/j.bbadis.2022.166488. Epub 2022 Jul 11. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35835414 Free article.

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What is the cause of increased mortality in normothermic patients with suspected infection?

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Platelet dysfunction after trauma: From mechanisms to targeted treatment.

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Myeloid DNA methyltransferase3b deficiency aggravates pulmonary fibrosis by enhancing profibrotic macrophage activation.

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Polypharmacy, comorbidity and frailty: a complex interplay in older patients at the emergency department.

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Effect of intravenous clarithromycin in patients with sepsis, respiratory and multiple organ dysfunction syndrome: a randomized clinical trial.

Karakike E, Scicluna BP, Roumpoutsou M, Mitrou I, Karampela N, Karageorgos A, Psaroulis K, Massa E, Pitsoulis A, Chaloulis P, Pappa E, Schrijver IT, Frantzeskaki F, Lada M, Dauby N, De Bels D, Floros I, Anisoglou S, Antoniadou E, Patrani M, Vlachogianni G, Mouloudi E, Antoniadou A, Grimaldi D, Roger T, Wiersinga WJ, Tsangaris I, Giamarellos-Bourboulis EJ. Karakike E, et al. Among authors: scicluna bp, wiersinga wj. Crit Care. 2022 Jun 18;26(1):183. doi: 10.1186/s13054-022-04055-4. Crit Care. 2022. PMID: 35717241 Free PMC article. Clinical Trial.

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Redefining critical illness.

Maslove DM, Tang B, Shankar-Hari M, Lawler PR, Angus DC, Baillie JK, Baron RM, Bauer M, Buchman TG, Calfee CS, Dos Santos CC, Giamarellos-Bourboulis EJ, Gordon AC, Kellum JA, Knight JC, Leligdowicz A, McAuley DF, McLean AS, Menon DK, Meyer NJ, Moldawer LL, Reddy K, Reilly JP, Russell JA, Sevransky JE, Seymour CW, Shapiro NI, Singer M, Summers C, Sweeney TE, Thompson BT, van der Poll T, Venkatesh B, Walley KR, Walsh TS, Ware LB, Wong HR, Zador ZE, Marshall JC. Maslove DM, et al. Among authors: van der poll t. Nat Med. 2022 Jun;28(6):1141-1148. doi: 10.1038/s41591-022-01843-x. Epub 2022 Jun 17. Nat Med. 2022. PMID: 35715504 Review.

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