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Bax suppresses tumorigenesis and stimulates apoptosis in vivo.
Yin C, Knudson CM, Korsmeyer SJ, Van Dyke T. Yin C, et al. Among authors: van dyke t. Nature. 1997 Feb 13;385(6617):637-40. doi: 10.1038/385637a0. Nature. 1997. PMID: 9024662
Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals.
Pérez de Castro I, Aguirre-Portolés C, Fernández-Miranda G, Cañamero M, Cowley DO, Van Dyke T, Malumbres M. Pérez de Castro I, et al. Among authors: van dyke t. Cancer Res. 2013 Nov 15;73(22):6804-15. doi: 10.1158/0008-5472.CAN-13-0586. Cancer Res. 2013. PMID: 24242071
Selective inactivation of p53 facilitates mouse epithelial tumor progression without chromosomal instability.
Lu X, Magrane G, Yin C, Louis DN, Gray J, Van Dyke T. Lu X, et al. Among authors: van dyke t. Mol Cell Biol. 2001 Sep;21(17):6017-30. doi: 10.1128/mcb.21.17.6017-6030.2001. Mol Cell Biol. 2001. PMID: 11486039 Free PMC article.
Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma.
Liao MJ, Van Dyke T. Liao MJ, et al. Among authors: van dyke t. Genes Dev. 1999 May 15;13(10):1246-50. doi: 10.1101/gad.13.10.1246. Genes Dev. 1999. PMID: 10346813 Free PMC article.
Chromosome translocations involving T cell receptor (TCR) loci have been found in tumors from Ataxia telangiectasia (AT) patients and in mouse Atm-/- thymoma, suggesting the involvement of V(D)J recombination in these malignancies. ...
Chromosome translocations involving T cell receptor (TCR) loci have been found in tumors from Ataxia telangiectasia (AT) patients and …
Atm is dispensable for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction.
Liao MJ, Yin C, Barlow C, Wynshaw-Boris A, van Dyke T. Liao MJ, et al. Among authors: van dyke t. Mol Cell Biol. 1999 Apr;19(4):3095-102. doi: 10.1128/mcb.19.4.3095. Mol Cell Biol. 1999. PMID: 10082576 Free PMC article.
These p53-mediated activities are induced by tissue-specific inactivation of pRb family proteins by a truncated simian virus 40 large T antigen in brain epithelium. ...
These p53-mediated activities are induced by tissue-specific inactivation of pRb family proteins by a truncated simian virus 40 large T
Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors.
Pan H, Yin C, Dyson NJ, Harlow E, Yamasaki L, Van Dyke T. Pan H, et al. Among authors: van dyke t. Mol Cell. 1998 Sep;2(3):283-92. doi: 10.1016/s1097-2765(00)80273-7. Mol Cell. 1998. PMID: 9774967
No requirement for V(D)J recombination in p53-deficient thymic lymphoma.
Liao MJ, Zhang XX, Hill R, Gao J, Qumsiyeh MB, Nichols W, Van Dyke T. Liao MJ, et al. Among authors: van dyke t. Mol Cell Biol. 1998 Jun;18(6):3495-501. doi: 10.1128/mcb.18.6.3495. Mol Cell Biol. 1998. PMID: 9584189 Free PMC article.
In mouse thymocytes, where p53 inactivation leads to tumorigenesis, several observations suggest that V(D)J recombination of T-cell receptor (TCR) loci could provide a DNA damage signal triggering p53-dependent apoptosis and tumor suppression. ...Recombination-activating g …
In mouse thymocytes, where p53 inactivation leads to tumorigenesis, several observations suggest that V(D)J recombination of T-cell r …
Apoptosis and cancer mechanisms.
Pan H, Yin C, Van Dyke T. Pan H, et al. Among authors: van dyke t. Cancer Surv. 1997;29:305-27. Cancer Surv. 1997. PMID: 9338106 Review.
Tissue-specific inactivation of p53 tumor suppression in the mouse.
Bowman T, Symonds H, Gu L, Yin C, Oren M, Van Dyke T. Bowman T, et al. Among authors: van dyke t. Genes Dev. 1996 Apr 1;10(7):826-35. doi: 10.1101/gad.10.7.826. Genes Dev. 1996. PMID: 8846919
Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration.
Wu H, Wade M, Krall L, Grisham J, Xiong Y, Van Dyke T. Wu H, et al. Among authors: van dyke t. Genes Dev. 1996 Feb 1;10(3):245-60. doi: 10.1101/gad.10.3.245. Genes Dev. 1996. PMID: 8595876
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