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The fecal metabolome and microbiome are altered in dogs with idiopathic epilepsy compared to healthy dogs.
Verdoodt F, Hesta M, Goossens E, Van Immerseel F, Molina J, Van Ham L, Vanhaecke L, Hemeryck LY, Bhatti SFM. Verdoodt F, et al. Among authors: van ham l. Sci Rep. 2025 Jul 25;15(1):27024. doi: 10.1038/s41598-025-09919-7. Sci Rep. 2025. PMID: 40707505 Free PMC article.
Idiopathic epilepsy (IE) is the most common chronic neurological disease in dogs, and a natural animal model for human epilepsy types with genetic and unknown etiology. The microbiota-gut-brain axis (MGBA) is a promising target for improving brain health in individu …
Idiopathic epilepsy (IE) is the most common chronic neurological disease in dogs, and a natural animal model for human epilepsy …
The influence of sex hormones on seizures in dogs and humans.
Van Meervenne SA, Volk HA, Matiasek K, Van Ham LM. Van Meervenne SA, et al. Among authors: van ham lm. Vet J. 2014 Jul;201(1):15-20. doi: 10.1016/j.tvjl.2014.05.008. Epub 2014 May 9. Vet J. 2014. PMID: 24878266 Review.
Catamenial epilepsy is defined as an increase in frequency and severity of seizures during certain periods of the menstrual cycle. ...The role of androgens is controversial and there is a lack of research focusing on androgens and epilepsy. Indeed, little is known a …
Catamenial epilepsy is defined as an increase in frequency and severity of seizures during certain periods of the menstrual cycle. .. …
The role of nutrition in canine idiopathic epilepsy management: Fact or fiction?
Verdoodt F, Watanangura A, Bhatti SFM, Schmidt T, Suchodolski JS, Van Ham L, Meller S, Volk HA, Hesta M. Verdoodt F, et al. Among authors: van ham l. Vet J. 2022 Dec;290:105917. doi: 10.1016/j.tvjl.2022.105917. Epub 2022 Oct 28. Vet J. 2022. PMID: 36341888 Review.
In the last decade, nutrition has gained interest in the management of canine idiopathic epilepsy (IE) based on growing scientific evidence. Diets can serve their functions through many pathways. ...
In the last decade, nutrition has gained interest in the management of canine idiopathic epilepsy (IE) based on growing scientific ev …
Associations between neutering and idiopathic epilepsy in Labrador retrievers and Border collies under primary veterinary care in the UK.
Van Meervenne S, Volk HA, Verhoeven PS, Van Ham L, O'Neill DG. Van Meervenne S, et al. Among authors: van ham l. Vet J. 2019 Oct;252:105354. doi: 10.1016/j.tvjl.2019.105354. Epub 2019 Aug 13. Vet J. 2019. PMID: 31554590
There are sparse published scientific data on associations between neutering and the severity and survival of dogs with idiopathic epilepsy. This study aimed to explore the timing of neutering with respect to onset of seizures in dogs with idiopathic epilepsy. ...Th …
There are sparse published scientific data on associations between neutering and the severity and survival of dogs with idiopathic epilep …
Association between estrus and onset of seizures in dogs with idiopathic epilepsy.
Van Meervenne SA, Volk HA, Van Ham LM. Van Meervenne SA, et al. Among authors: van ham lm. J Vet Intern Med. 2015 Jan;29(1):251-3. doi: 10.1111/jvim.12505. Epub 2014 Nov 19. J Vet Intern Med. 2015. PMID: 25408276 Free PMC article.
BACKGROUND: Catamenial epilepsy in humans is defined as changes in seizure frequency over the course of the menstrual cycle. ...RESULTS: Of the 45 dogs with idiopathic epilepsy, 17 (38%) had their first seizure when in heat and six dogs (13%) had their first seizure …
BACKGROUND: Catamenial epilepsy in humans is defined as changes in seizure frequency over the course of the menstrual cycle. ...RESUL …
Identification of a Novel Idiopathic Epilepsy Risk Locus and a Variant in the CCDC85A Gene in the Dutch Partridge Dog.
Beckers E, Bhatti SFM, Van Poucke M, Polis I, Farnir F, Van Nieuwerburgh F, Mandigers P, Van Ham L, Peelman L, Broeckx BJG. Beckers E, et al. Among authors: van ham l. Animals (Basel). 2023 Feb 23;13(5):810. doi: 10.3390/ani13050810. Animals (Basel). 2023. PMID: 36899667 Free PMC article.
(1) Idiopathic epilepsy (IE) is thought to have a genetic cause in several dog breeds. However, only two causal variants have been identified to date, and few risk loci are known. ...
(1) Idiopathic epilepsy (IE) is thought to have a genetic cause in several dog breeds. However, only two causal variants have been id …
Non-pharmacological treatment options for refractory epilepsy: an overview of human treatment modalities and their potential utility in dogs.
Martlé V, Van Ham L, Raedt R, Vonck K, Boon P, Bhatti S. Martlé V, et al. Among authors: van ham l. Vet J. 2014 Mar;199(3):332-9. doi: 10.1016/j.tvjl.2013.09.055. Epub 2013 Oct 30. Vet J. 2014. PMID: 24309438 Review.
Refractory epilepsy is a common disorder both in humans and dogs and treatment protocols are difficult to optimise. ...The ketogenic diet is indicated in severe childhood epilepsies, but efficacy is limited and long-term compliance can be problematic. In the past de …
Refractory epilepsy is a common disorder both in humans and dogs and treatment protocols are difficult to optimise. ...The ketogenic …
Towards a better understanding of idiopathic epilepsy through metabolic fingerprinting of cerebrospinal fluid in dogs.
Verdoodt F, Bhatti SFM, Kragic K, Van Ham L, Vanhaecke L, Hesta M, Hemeryck LY. Verdoodt F, et al. Among authors: van ham l. Sci Rep. 2024 Jun 26;14(1):14750. doi: 10.1038/s41598-024-64777-z. Sci Rep. 2024. PMID: 38926488 Free PMC article.
Consequently, metabolic alterations in CSF of dogs with idiopathic epilepsy (IE) were studied by comparing CSF of dogs diagnosed with IE (Tier II) to dogs with non-brain related disease. ...
Consequently, metabolic alterations in CSF of dogs with idiopathic epilepsy (IE) were studied by comparing CSF of dogs diagnosed with …
Plasma metabolome reveals altered oxidative stress, inflammation, and amino acid metabolism in dogs with idiopathic epilepsy.
Verdoodt F, Bhatti SFM, Molina J, Van Ham L, Vanhaecke L, Junius G, Hemeryck LY, Hesta M. Verdoodt F, et al. Among authors: van ham l. Epilepsia. 2025 Apr;66(4):1315-1328. doi: 10.1111/epi.18256. Epub 2025 Jan 13. Epilepsia. 2025. PMID: 39804158 Free PMC article.
OBJECTIVE: Idiopathic epilepsy (IE) is the most common chronic neurological disease in dogs and an established natural animal model for human epilepsy types with genetic and unknown etiology. ...SIGNIFICANCE: Our data provide new insights into the metabolic pathways …
OBJECTIVE: Idiopathic epilepsy (IE) is the most common chronic neurological disease in dogs and an established natural animal model f …
Imepitoin withdrawal in dogs with idiopathic epilepsy well-controlled with imepitoin and phenobarbital and/or potassium bromide does not increase seizure frequency.
Stee K, Martlé V, Broeckx BJG, Royaux E, Van Ham L, Bhatti SFM. Stee K, et al. Among authors: van ham l. Vet J. 2017 Dec;230:1-5. doi: 10.1016/j.tvjl.2017.10.003. Epub 2017 Oct 12. Vet J. 2017. PMID: 29208209
Phenobarbital or potassium bromide (KBr) add-on treatment decreases the average monthly seizure frequency in dogs with idiopathic epilepsy resistant to a maximum dose of imepitoin. The importance of continued administration of imepitoin in these dogs is currently unknown. …
Phenobarbital or potassium bromide (KBr) add-on treatment decreases the average monthly seizure frequency in dogs with idiopathic epileps …
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