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A flexible, image-based, high-throughput platform encompassing in-depth cell profiling to identify broad-spectrum coronavirus antivirals with limited off-target effects.
Doijen J, Heo I, Temmerman K, Vermeulen P, Diels A, Jaensch S, Burcin M, Van den Broeck N, Raeymaekers V, Peremans J, Konings K, Clement M, Peeters D, Van Loock M, Koul A, Buyck C, Van Gool M, Van Damme E. Doijen J, et al. Among authors: van loock m. Antiviral Res. 2024 Feb;222:105789. doi: 10.1016/j.antiviral.2023.105789. Epub 2023 Dec 27. Antiviral Res. 2024. PMID: 38158129 Free article.
Could prophylactic antivirals reduce dengue incidence in a high-prevalence endemic area?
Jafari Y, Brady OJ, Biggs JR, Lien LT, Mai HK, Nguyen HAT, Van Loock M, Herrera-Taracena G, Menten J, Iwasaki C, Takegata M, Kitamura N, Do Thai H, Minh BX, Morita K, Anh DD, Clifford S, Prem K, Hafalla J, Edmunds WJ, Yoshida LM, Hibberd ML, Hué S. Jafari Y, et al. Among authors: van loock m. PLoS Negl Trop Dis. 2024 Jul 29;18(7):e0012334. doi: 10.1371/journal.pntd.0012334. eCollection 2024 Jul. PLoS Negl Trop Dis. 2024. PMID: 39074158 Free PMC article.
Antiviral target compound profile for pandemic preparedness.
Demarest JF, Draghia-Akli R, Cihlar T, Bradley K, Young JAT, Chandra R, Vaidyanathan S, Chu-Moyer M, Lynch CL, Campbell A, Saikatendu KS, Bilello JP, Murata Y, van Loock M, Hurt AC, Tellinghuisen T, Ruggiero L, Mackman R, Hill NM, Pottage JC Jr; INTREPID Alliance. Demarest JF, et al. Among authors: van loock m. Nat Rev Drug Discov. 2025 Feb;24(2):151-152. doi: 10.1038/s41573-024-01102-3. Nat Rev Drug Discov. 2025. PMID: 39622985 No abstract available.
Quantifying temporal differences in the induction of interferon-mediated signalling observed in a dengue virus 1 human infection model: insights from longitudinal proteome analysis.
Struyfs C, Van den Heede K, Van Wesenbeeck L, Waickman AT, Rasschaert F, Herrera-Taracena G, Thomas SJ, Van Loock M, Lagatie O. Struyfs C, et al. Among authors: van loock m. EBioMedicine. 2025 May;115:105728. doi: 10.1016/j.ebiom.2025.105728. Epub 2025 Apr 26. EBioMedicine. 2025. PMID: 40288237 Free PMC article.
Daily Mosnodenvir as Dengue Prophylaxis in a Controlled Human Infection Model.
Durbin AP, Van Wesenbeeck L, Pierce KK, Herrera-Taracena G, Ebone L, Buelens A, Lutton P, Sabundayo BP, Van Eygen V, De Clerck K, Fetter I, Voge NV, Fang X, Goeyvaerts N, Vandendijck Y, Mayfield J, Lenz O, De Meyer S, Kakuda TN, He H, Amaro-Carambot E, Akli RD, Carmolli M, De Marez T, Whitehead SS, Van Loock M, Rasschaert F. Durbin AP, et al. Among authors: van loock m. N Engl J Med. 2025 Nov 27;393(21):2107-2118. doi: 10.1056/NEJMoa2500179. N Engl J Med. 2025. PMID: 41297006 Free PMC article. Clinical Trial.
A New Fragment-Based Pharmacophore Virtual Screening Workflow Identifies Potent Inhibitors of SARS-CoV-2 NSP13 Helicase.
Doijen J, Xie J, Marsili S, Bains T, Mann MK, Abeywickrema P, Van den Broeck N, Permann C, Langer T, Ibis G, Mattelaer CA, Harvey J, van Raalte S, Fino R, Pande V, Peeters D, Patrick A, Van Damme E, van Vlijmen H, Van Loock M, Jacoby E. Doijen J, et al. Among authors: van loock m. J Comput Chem. 2025 Sep 5;46(23):e70201. doi: 10.1002/jcc.70201. J Comput Chem. 2025. PMID: 40910569 Free PMC article.
A Prospective Cohort Study of Primary Dengue Virus Infection in Medellín, Colombia.
Trujillo A, Van Wesenbeeck L, Salazar L, López L, Tambuyzer L, Buelens A, Clerck K, Lenz O, Vijgen L, Van Loock M, Herrera-Taracena G, Vélez ID, Rasschaert F. Trujillo A, et al. Among authors: van loock m. Vaccines (Basel). 2025 Jul 12;13(7):748. doi: 10.3390/vaccines13070748. Vaccines (Basel). 2025. PMID: 40733724 Free PMC article.
A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein.
Van Damme E, Abeywickrema P, Yin Y, Xie J, Jacobs S, Mann MK, Doijen J, Miller R, Piassek M, Marsili S, Subramanian M, Gottlieb L, Abdelnabi R, Van Gool M, Van den Broeck N, De Pauw I, Diels A, Vermeulen P, Temmerman K, Scobey T, Mattocks M, Schäfer A, Jochmans D, De Jonghe S, Leyssen P, Chiu W, Diosa Toro M, Zwaagstra M, Leijs AA, De Gruyter HLM, Buyck C, Van Den Heede K, Jacobs F, Van den Eynde C, Thijs L, Raeymaekers V, Miller S, Del Rosario A, Neyts J, Peeters D, Baric RS, van Kuppeveld FJM, Snijder EJ, van Hemert MJ, Monshouwer M, Sharma S, Draghia-Akli R, Koul A, Van Loock M. Van Damme E, et al. Among authors: van loock m. Nature. 2025 Apr;640(8058):506-513. doi: 10.1038/s41586-025-08651-6. Epub 2025 Mar 26. Nature. 2025. PMID: 40140563 Free PMC article.
Pan-serotype dengue virus inhibitor JNJ-A07 targets NS4A-2K-NS4B interaction with NS2B/NS3 and blocks replication organelle formation.
Kiemel D, Kroell AH, Denolly S, Haselmann U, Bonfanti JF, Andres JI, Ghosh B, Geluykens P, Kaptein SJF, Wilken L, Scaturro P, Neyts J, Van Loock M, Goethals O, Bartenschlager R. Kiemel D, et al. Among authors: van loock m. Nat Commun. 2024 Jul 19;15(1):6080. doi: 10.1038/s41467-024-50437-3. Nat Commun. 2024. PMID: 39030239 Free PMC article.
79 results