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Structure and function of the small heat shock protein/alpha-crystallin family of molecular chaperones.
Van Montfort R, Slingsby C, Vierling E. Van Montfort R, et al. Adv Protein Chem. 2001;59:105-56. doi: 10.1016/s0065-3233(01)59004-x. Adv Protein Chem. 2001. PMID: 11868270 Review. No abstract available.
Crystal structure of eta-crystallin: adaptation of a class 1 aldehyde dehydrogenase for a new role in the eye lens.
Bateman OA, Purkiss AG, van Montfort R, Slingsby C, Graham C, Wistow G. Bateman OA, et al. Among authors: van montfort r. Biochemistry. 2003 Apr 22;42(15):4349-56. doi: 10.1021/bi027367w. Biochemistry. 2003. PMID: 12693930
Crystal structure of truncated human betaB1-crystallin.
Van Montfort RL, Bateman OA, Lubsen NH, Slingsby C. Van Montfort RL, et al. Protein Sci. 2003 Nov;12(11):2606-12. doi: 10.1110/ps.03265903. Protein Sci. 2003. PMID: 14573871 Free PMC article.
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen.
Cheeseman MD, Chessum NE, Rye CS, Pasqua AE, Tucker MJ, Wilding B, Evans LE, Lepri S, Richards M, Sharp SY, Ali S, Rowlands M, O'Fee L, Miah A, Hayes A, Henley AT, Powers M, Te Poele R, De Billy E, Pellegrino L, Raynaud F, Burke R, van Montfort RL, Eccles SA, Workman P, Jones K. Cheeseman MD, et al. Among authors: van montfort rl. J Med Chem. 2017 Jan 12;60(1):180-201. doi: 10.1021/acs.jmedchem.6b01055. Epub 2016 Dec 22. J Med Chem. 2017. PMID: 28004573 Free PMC article.
A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Jones AM, Westwood IM, Osborne JD, Matthews TP, Cheeseman MD, Rowlands MG, Jeganathan F, Burke R, Lee D, Kadi N, Liu M, Richards M, McAndrew C, Yahya N, Dobson SE, Jones K, Workman P, Collins I, van Montfort RL. Jones AM, et al. Among authors: van montfort rl. Sci Rep. 2016 Oct 6;6:34701. doi: 10.1038/srep34701. Sci Rep. 2016. PMID: 27708405 Free PMC article.
Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1).
Naud S, Westwood IM, Faisal A, Sheldrake P, Bavetsias V, Atrash B, Cheung KM, Liu M, Hayes A, Schmitt J, Wood A, Choi V, Boxall K, Mak G, Gurden M, Valenti M, de Haven Brandon A, Henley A, Baker R, McAndrew C, Matijssen B, Burke R, Hoelder S, Eccles SA, Raynaud FI, Linardopoulos S, van Montfort RL, Blagg J. Naud S, et al. Among authors: van montfort rl. J Med Chem. 2013 Dec 27;56(24):10045-65. doi: 10.1021/jm401395s. Epub 2013 Dec 2. J Med Chem. 2013. PMID: 24256217 Free PMC article.
Crystal structure and assembly of a eukaryotic small heat shock protein.
van Montfort RL, Basha E, Friedrich KL, Slingsby C, Vierling E. van Montfort RL, et al. Nat Struct Biol. 2001 Dec;8(12):1025-30. doi: 10.1038/nsb722. Nat Struct Biol. 2001. PMID: 11702068
Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70.
Cheeseman MD, Westwood IM, Barbeau O, Rowlands M, Dobson S, Jones AM, Jeganathan F, Burke R, Kadi N, Workman P, Collins I, van Montfort RL, Jones K. Cheeseman MD, et al. Among authors: van montfort rl. J Med Chem. 2016 May 26;59(10):4625-36. doi: 10.1021/acs.jmedchem.5b02001. Epub 2016 May 11. J Med Chem. 2016. PMID: 27119979 Free PMC article.
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach.
Innocenti P, Woodward HL, Solanki S, Naud S, Westwood IM, Cronin N, Hayes A, Roberts J, Henley AT, Baker R, Faisal A, Mak GW, Box G, Valenti M, De Haven Brandon A, O'Fee L, Saville H, Schmitt J, Matijssen B, Burke R, van Montfort RL, Raynaud FI, Eccles SA, Linardopoulos S, Blagg J, Hoelder S. Innocenti P, et al. Among authors: van montfort rl. J Med Chem. 2016 Apr 28;59(8):3671-88. doi: 10.1021/acs.jmedchem.5b01811. Epub 2016 Apr 7. J Med Chem. 2016. PMID: 27055065
Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors.
Howard N, Abell C, Blakemore W, Chessari G, Congreve M, Howard S, Jhoti H, Murray CW, Seavers LC, van Montfort RL. Howard N, et al. J Med Chem. 2006 Feb 23;49(4):1346-55. doi: 10.1021/jm050850v. J Med Chem. 2006. PMID: 16480269
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