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Structural insights into the nirmatrelvir-resistant SARS-CoV-2 Mpro L50F/E166A/L167F triple mutant-inhibitor-complex reveal strategies for next generation coronaviral inhibitor design.
Fischer C, Lu J, van Belkum MJ, Demmon S, Chen P, Wang C, Van Oers TJ, Lamer T, Lemieux MJ, Vederas JC. Fischer C, et al. Among authors: van oers tj. RSC Med Chem. 2025 Aug 15;16(10):5032-5040. doi: 10.1039/d5md00356c. eCollection 2025 Oct 15. RSC Med Chem. 2025. PMID: 40823489 Free PMC article.