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BRCA1 and BRCA2 heterozygosity and repair of X-ray-induced DNA damage.
Nieuwenhuis B, Van Assen-Bolt AJ, Van Waarde-Verhagen MA, Sijmons RH, Van der Hout AH, Bauch T, Streffer C, Kampinga HH. Nieuwenhuis B, et al. Among authors: van waarde verhagen ma. Int J Radiat Biol. 2002 Apr;78(4):285-95. doi: 10.1080/09553000110097974. Int J Radiat Biol. 2002. PMID: 12020440
Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome.
Huiting W, Dekker SL, van der Lienden JCJ, Mergener R, Musskopf MK, Furtado GV, Gerrits E, Coit D, Oghbaie M, Di Stefano LH, Schepers H, van Waarde-Verhagen MAWH, Couzijn S, Barazzuol L, LaCava J, Kampinga HH, Bergink S. Huiting W, et al. Among authors: van waarde verhagen mawh. Elife. 2022 Feb 24;11:e70726. doi: 10.7554/eLife.70726. Elife. 2022. PMID: 35200138 Free PMC article.
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers.
Mannini B, Cascella R, Zampagni M, van Waarde-Verhagen M, Meehan S, Roodveldt C, Campioni S, Boninsegna M, Penco A, Relini A, Kampinga HH, Dobson CM, Wilson MR, Cecchi C, Chiti F. Mannini B, et al. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12479-84. doi: 10.1073/pnas.1117799109. Epub 2012 Jul 16. Proc Natl Acad Sci U S A. 2012. PMID: 22802614 Free PMC article.