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The inhibitory receptor FcgammaRII reduces joint inflammation and destruction in experimental immune complex-mediated arthritides not only by inhibition of FcgammaRI/III but also by efficient clearance and endocytosis of immune complexes.
van Lent P, Nabbe KC, Boross P, Blom AB, Roth J, Holthuysen A, Sloetjes A, Verbeek S, van den Berg W. van Lent P, et al. Am J Pathol. 2003 Nov;163(5):1839-48. doi: 10.1016/s0002-9440(10)63543-2. Am J Pathol. 2003. PMID: 14578184 Free PMC article.
Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction.
Wehmeyer C, Frank S, Beckmann D, Böttcher M, Cromme C, König U, Fennen M, Held A, Paruzel P, Hartmann C, Stratis A, Korb-Pap A, Kamradt T, Kramer I, van den Berg W, Kneissel M, Pap T, Dankbar B. Wehmeyer C, et al. Sci Transl Med. 2016 Mar 16;8(330):330ra35. doi: 10.1126/scitranslmed.aac4351. Epub 2016 Mar 16. Sci Transl Med. 2016. PMID: 27089204
GM-CSF as a therapeutic target in inflammatory diseases.
van Nieuwenhuijze A, Koenders M, Roeleveld D, Sleeman MA, van den Berg W, Wicks IP. van Nieuwenhuijze A, et al. Mol Immunol. 2013 Dec;56(4):675-82. doi: 10.1016/j.molimm.2013.05.002. Epub 2013 Aug 8. Mol Immunol. 2013. PMID: 23933508 Review.
Monocytic cell differentiation from band-stage neutrophils under inflammatory conditions via MKK6 activation.
Köffel R, Meshcheryakova A, Warszawska J, Hennig A, Wagner K, Jörgl A, Gubi D, Moser D, Hladik A, Hoffmann U, Fischer MB, van den Berg W, Koenders M, Scheinecker C, Gesslbauer B, Knapp S, Strobl H. Köffel R, et al. Blood. 2014 Oct 23;124(17):2713-24. doi: 10.1182/blood-2014-07-588178. Epub 2014 Sep 11. Blood. 2014. PMID: 25214442 Free PMC article.
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