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A safe and highly efficient tumor-targeted type I interferon immunotherapy depends on the tumor microenvironment.
Cauwels A, Van Lint S, Garcin G, Bultinck J, Paul F, Gerlo S, Van der Heyden J, Bordat Y, Catteeuw D, De Cauwer L, Rogge E, Verhee A, Uzé G, Tavernier J. Cauwels A, et al. Among authors: Van Lint S, Van der Heyden J. Oncoimmunology. 2017 Nov 27;7(3):e1398876. doi: 10.1080/2162402X.2017.1398876. eCollection 2018. Oncoimmunology. 2017. PMID: 29399401 Free PMC article.
High efficiency cell-specific targeting of cytokine activity.
Garcin G, Paul F, Staufenbiel M, Bordat Y, Van der Heyden J, Wilmes S, Cartron G, Apparailly F, De Koker S, Piehler J, Tavernier J, Uzé G. Garcin G, et al. Among authors: Van der Heyden J. Nat Commun. 2014;5:3016. doi: 10.1038/ncomms4016. Nat Commun. 2014. PMID: 24398568
Delivering Type I Interferon to Dendritic Cells Empowers Tumor Eradication and Immune Combination Treatments.
Cauwels A, Van Lint S, Paul F, Garcin G, De Koker S, Van Parys A, Wueest T, Gerlo S, Van der Heyden J, Bordat Y, Catteeuw D, Rogge E, Verhee A, Vandekerckhove B, Kley N, Uzé G, Tavernier J. Cauwels A, et al. Among authors: Van Lint S, Van Parys A, Van der Heyden J. Cancer Res. 2018 Jan 15;78(2):463-474. doi: 10.1158/0008-5472.CAN-17-1980. Epub 2017 Nov 29. Cancer Res. 2018. PMID: 29187401
Theranostic Radiolabeled Anti-CD20 sdAb for Targeted Radionuclide Therapy of Non-Hodgkin Lymphoma.
Krasniqi A, D'Huyvetter M, Xavier C, Van der Jeught K, Muyldermans S, Van Der Heyden J, Lahoutte T, Tavernier J, Devoogdt N. Krasniqi A, et al. Among authors: Van der Jeught K, Van Der Heyden J. Mol Cancer Ther. 2017 Dec;16(12):2828-2839. doi: 10.1158/1535-7163.MCT-17-0554. Epub 2017 Oct 20. Mol Cancer Ther. 2017. PMID: 29054987
MAPPIT as a high-throughput screening assay for modulators of protein-protein interactions in HIV and HCV.
Van Schoubroeck B, Van Acker K, Dams G, Jochmans D, Clayton R, Berke JM, Lievens S, Van der Heyden J, Tavernier J. Van Schoubroeck B, et al. Among authors: Van Acker K, Van der Heyden J. Methods Mol Biol. 2012;812:295-307. doi: 10.1007/978-1-61779-455-1_18. Methods Mol Biol. 2012. PMID: 22218868
Neutralizing monoclonal antibodies can potentiate IL-5 signaling.
Zabeau L, Van der Heyden J, Broekaert D, Verhee A, Vandekerckhove J, Wu SJ, Chaiken I, Heinrich P, Behrmann I, Tavernier J. Zabeau L, et al. Among authors: Van der Heyden J. Eur J Immunol. 2001 Apr;31(4):1087-97. doi: 10.1002/1521-4141(200104)31:4<1087::aid-immu1087>3.0.co;2-q. Eur J Immunol. 2001. PMID: 11298333
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