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Aerobic glycolysis: meeting the metabolic requirements of cell proliferation.
Lunt SY, Vander Heiden MG. Lunt SY, et al. Among authors: vander heiden mg. Annu Rev Cell Dev Biol. 2011;27:441-64. doi: 10.1146/annurev-cellbio-092910-154237. Annu Rev Cell Dev Biol. 2011. PMID: 21985671 Review.
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability.
Rathmell JC, Vander Heiden MG, Harris MH, Frauwirth KA, Thompson CB. Rathmell JC, et al. Among authors: vander heiden mg. Mol Cell. 2000 Sep;6(3):683-92. doi: 10.1016/s1097-2765(00)00066-6. Mol Cell. 2000. PMID: 11030347
Growth factors can influence cell growth and survival through effects on glucose metabolism.
Vander Heiden MG, Plas DR, Rathmell JC, Fox CJ, Harris MH, Thompson CB. Vander Heiden MG, et al. Mol Cell Biol. 2001 Sep;21(17):5899-912. doi: 10.1128/mcb.21.17.5899-5912.2001. Mol Cell Biol. 2001. PMID: 11486029 Free PMC article.
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC. Christofk HR, et al. Among authors: vander heiden mg. Nature. 2008 Mar 13;452(7184):230-3. doi: 10.1038/nature06734. Nature. 2008. PMID: 18337823
Understanding the Warburg effect: the metabolic requirements of cell proliferation.
Vander Heiden MG, Cantley LC, Thompson CB. Vander Heiden MG, et al. Science. 2009 May 22;324(5930):1029-33. doi: 10.1126/science.1160809. Science. 2009. PMID: 19460998 Free PMC article. Review.
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.
Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ, Xie J, Gu TL, Polakiewicz RD, Roesel JL, Boggon TJ, Khuri FR, Gilliland DG, Cantley LC, Kaufman J, Chen J. Hitosugi T, et al. Among authors: vander heiden mg. Sci Signal. 2009 Nov 17;2(97):ra73. doi: 10.1126/scisignal.2000431. Sci Signal. 2009. PMID: 19920251 Free PMC article.
Identification of small molecule inhibitors of pyruvate kinase M2.
Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC. Vander Heiden MG, et al. Biochem Pharmacol. 2010 Apr 15;79(8):1118-24. doi: 10.1016/j.bcp.2009.12.003. Epub 2009 Dec 11. Biochem Pharmacol. 2010. PMID: 20005212 Free PMC article.
Evidence for an alternative glycolytic pathway in rapidly proliferating cells.
Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC. Vander Heiden MG, et al. Science. 2010 Sep 17;329(5998):1492-9. doi: 10.1126/science.1188015. Science. 2010. PMID: 20847263 Free PMC article.
Rewiring of glycolysis in cancer cell metabolism.
Locasale JW, Vander Heiden MG, Cantley LC. Locasale JW, et al. Among authors: vander heiden mg. Cell Cycle. 2010 Nov 1;9(21):4253. doi: 10.4161/cc.9.21.13925. Epub 2010 Nov 7. Cell Cycle. 2010. PMID: 21045562 No abstract available.
ATP consumption promotes cancer metabolism.
Israelsen WJ, Vander Heiden MG. Israelsen WJ, et al. Among authors: vander heiden mg. Cell. 2010 Nov 24;143(5):669-71. doi: 10.1016/j.cell.2010.11.010. Cell. 2010. PMID: 21111226
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