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Modulation of the Substitution Pattern of 5-Aryl-2-Aminoimidazoles Allows Fine-Tuning of Their Antibiofilm Activity Spectrum and Toxicity.
Peeters E, Hooyberghs G, Robijns S, Waldrant K, De Weerdt A, Delattin N, Liebens V, Kucharíková S, Tournu H, Verstraeten N, Dovgan B, Girandon L, Fröhlich M, De Brucker K, Van Dijck P, Michiels J, Cammue BP, Thevissen K, Vanderleyden J, Van der Eycken E, Steenackers HP. Peeters E, et al. Among authors: vanderleyden j. Antimicrob Agents Chemother. 2016 Oct 21;60(11):6483-6497. doi: 10.1128/AAC.00035-16. Print 2016 Nov. Antimicrob Agents Chemother. 2016. PMID: 27550355 Free PMC article.
Structure-activity relationship of 4(5)-aryl-2-amino-1H-imidazoles, N1-substituted 2-aminoimidazoles and imidazo[1,2-a]pyrimidinium salts as inhibitors of biofilm formation by Salmonella typhimurium and Pseudomonas aeruginosa.
Steenackers HP, Ermolat'ev DS, Savaliya B, De Weerdt A, De Coster D, Shah A, Van der Eycken EV, De Vos DE, Vanderleyden J, De Keersmaecker SC. Steenackers HP, et al. Among authors: vanderleyden j. J Med Chem. 2011 Jan 27;54(2):472-84. doi: 10.1021/jm1011148. Epub 2010 Dec 20. J Med Chem. 2011. PMID: 21174477
Evaluation of the toxicity of 5-aryl-2-aminoimidazole-based biofilm inhibitors against eukaryotic cell lines, bone cells and the nematode Caenorhabditis elegans.
Steenackers H, Dubey A, Robijns S, Ermolat'ev D, Delattin N, Dovgan B, Girandon L, Fröhlich M, De Brucker K, Cammue BP, Thevissen K, Balzarini J, Van der Eycken EV, Vanderleyden J. Steenackers H, et al. Among authors: vanderleyden j. Molecules. 2014 Oct 16;19(10):16707-23. doi: 10.3390/molecules191016707. Molecules. 2014. PMID: 25325155 Free PMC article.
Antibacterial activity of a new broad-spectrum antibiotic covalently bound to titanium surfaces.
Gerits E, Kucharíková S, Van Dijck P, Erdtmann M, Krona A, Lövenklev M, Fröhlich M, Dovgan B, Impellizzeri F, Braem A, Vleugels J, Robijns SC, Steenackers HP, Vanderleyden J, De Brucker K, Thevissen K, Cammue BP, Fauvart M, Verstraeten N, Michiels J. Gerits E, et al. Among authors: vanderleyden j. J Orthop Res. 2016 Dec;34(12):2191-2198. doi: 10.1002/jor.23238. Epub 2016 Apr 6. J Orthop Res. 2016. PMID: 27003909 Free article.
An antibiofilm coating of 5-aryl-2-aminoimidazole covalently attached to a titanium surface.
Peeters E, Hooyberghs G, Robijns S, De Weerdt A, Kucharíková S, Tournu H, Braem A, Čeh K, Majdič G, Španič T, Pogorevc E, Claes B, Dovgan B, Girandon L, Impellizzeri F, Erdtmann M, Krona A, Vleugels J, Fröhlich M, Garcia-Forgas J, De Brucker K, Cammue BPA, Thevissen K, Van Dijck P, Vanderleyden J, Van der Eycken E, Steenackers HP. Peeters E, et al. Among authors: vanderleyden j. J Biomed Mater Res B Appl Biomater. 2019 Aug;107(6):1908-1919. doi: 10.1002/jbm.b.34283. Epub 2018 Dec 13. J Biomed Mater Res B Appl Biomater. 2019. PMID: 30549192
Structure-activity relationship of 2-hydroxy-2-aryl-2,3-dihydro-imidazo[1,2-a]pyrimidinium salts and 2N-substituted 4(5)-aryl-2-amino-1H-imidazoles as inhibitors of biofilm formation by Salmonella Typhimurium and Pseudomonas aeruginosa.
Steenackers HP, Ermolat'ev DS, Savaliya B, Weerdt AD, Coster DD, Shah A, Van der Eycken EV, De Vos DE, Vanderleyden J, De Keersmaecker SC. Steenackers HP, et al. Among authors: vanderleyden j. Bioorg Med Chem. 2011 Jun 1;19(11):3462-73. doi: 10.1016/j.bmc.2011.04.026. Epub 2011 Apr 19. Bioorg Med Chem. 2011. PMID: 21550812
Smart Metal-Organic Framework Coatings: Triggered Antibiofilm Compound Release.
Claes B, Boudewijns T, Muchez L, Hooyberghs G, Van der Eycken EV, Vanderleyden J, Steenackers HP, De Vos DE. Claes B, et al. Among authors: vanderleyden j. ACS Appl Mater Interfaces. 2017 Feb 8;9(5):4440-4449. doi: 10.1021/acsami.6b14152. Epub 2017 Jan 24. ACS Appl Mater Interfaces. 2017. PMID: 28081368
Experimental evolution in biofilm populations.
Steenackers HP, Parijs I, Dubey A, Foster KR, Vanderleyden J. Steenackers HP, et al. Among authors: vanderleyden j. FEMS Microbiol Rev. 2016 May;40(3):373-97. doi: 10.1093/femsre/fuw002. Epub 2016 Feb 18. FEMS Microbiol Rev. 2016. PMID: 26895713 Free PMC article. Review.
306 results