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Therapeutic Mechanisms of Glucocorticoids.
Vandewalle J, Luypaert A, De Bosscher K, Libert C. Vandewalle J, et al. Trends Endocrinol Metab. 2018 Jan;29(1):42-54. doi: 10.1016/j.tem.2017.10.010. Epub 2017 Nov 20. Trends Endocrinol Metab. 2018. PMID: 29162310 Review.
Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1.
Puimège L, Van Hauwermeiren F, Steeland S, Van Ryckeghem S, Vandewalle J, Lodens S, Dejager L, Vandevyver S, Staelens J, Timmermans S, Vandenbroucke RE, Libert C. Puimège L, et al. Among authors: vandewalle j. EMBO Mol Med. 2015 Aug;7(8):1004-17. doi: 10.15252/emmm.201405010. EMBO Mol Med. 2015. PMID: 25995337 Free PMC article.
Glucocorticoid Receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor.
Petta I, Bougarne N, Vandewalle J, Dejager L, Vandevyver S, Ballegeer M, Desmet S, Thommis J, De Cauwer L, Lievens S, Libert C, Tavernier J, De Bosscher K. Petta I, et al. Among authors: vandewalle j. Sci Rep. 2017 Aug 21;7(1):8941. doi: 10.1038/s41598-017-09246-6. Sci Rep. 2017. PMID: 28827617 Free PMC article.
Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis.
Steeland S, Van Ryckeghem S, Vandewalle J, Ballegeer M, Van Wonterghem E, Eggermont M, Decruyenaere J, De Bus L, Libert C, Vandenbroucke RE. Steeland S, et al. Among authors: vandewalle j. Crit Care Med. 2018 Jan;46(1):e67-e75. doi: 10.1097/CCM.0000000000002813. Crit Care Med. 2018. PMID: 29095202
Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice.
Ballegeer M, Van Looveren K, Timmermans S, Eggermont M, Vandevyver S, Thery F, Dendoncker K, Souffriau J, Vandewalle J, Van Wyngene L, De Rycke R, Takahashi N, Vandenabeele P, Tuckermann J, Reichardt HM, Impens F, Beyaert R, De Bosscher K, Vandenbroucke RE, Libert C. Ballegeer M, et al. Among authors: vandewalle j. J Clin Invest. 2018 Aug 1;128(8):3265-3279. doi: 10.1172/JCI96636. Epub 2018 Jun 25. J Clin Invest. 2018. PMID: 29746256 Free PMC article.
Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
Van Wyngene L, Vandewalle J, Libert C. Van Wyngene L, et al. Among authors: vandewalle j. EMBO Mol Med. 2018 Aug;10(8):e8712. doi: 10.15252/emmm.201708712. EMBO Mol Med. 2018. PMID: 29976786 Free PMC article. Review.
Overexpression of Gilz Protects Mice Against Lethal Septic Peritonitis.
Ballegeer M, Vandewalle J, Eggermont M, Van Isterdael G, Dejager L, De Bus L, Decruyenaere J, Vandenbroucke RE, Libert C. Ballegeer M, et al. Among authors: vandewalle j. Shock. 2019 Aug;52(2):208-214. doi: 10.1097/SHK.0000000000001252. Shock. 2019. PMID: 30124596
TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.
Dendoncker K, Timmermans S, Vandewalle J, Eggermont M, Lempiäinen J, Paakinaho V, Van Hamme E, Dewaele S, Vandevyver S, Ballegeer M, Souffriau J, Van Wyngene L, Van Looveren K, Vanderhaeghen T, Beyaert R, De Bosscher K, Palvimo JJ, Van Montagu M, Libert C. Dendoncker K, et al. Among authors: vandewalle j. Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12942-12951. doi: 10.1073/pnas.1821565116. Epub 2019 Jun 10. Proc Natl Acad Sci U S A. 2019. PMID: 31182584 Free PMC article.
GILZ in sepsis: "Poor is the pupil who does not surpass his master".
Vandewalle J, Libert C. Vandewalle J, et al. Eur J Immunol. 2020 Apr;50(4):490-493. doi: 10.1002/eji.202048582. Epub 2020 Mar 13. Eur J Immunol. 2020. PMID: 32103492
Taking the STING Out of Sepsis?
Vandewalle J, Vanderhaeghen T, Beyaert R, Libert C. Vandewalle J, et al. Cell Host Microbe. 2020 Apr 8;27(4):491-493. doi: 10.1016/j.chom.2020.03.016. Cell Host Microbe. 2020. PMID: 32272071
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