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Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues.
Lisco A, Vanpouille C, Tchesnokov EP, Grivel JC, Biancotto A, Brichacek B, Elliott J, Fromentin E, Shattock R, Anton P, Gorelick R, Balzarini J, McGuigan C, Derudas M, Götte M, Schinazi RF, Margolis L. Lisco A, et al. Among authors: vanpouille c. Cell Host Microbe. 2008 Sep 11;4(3):260-270. doi: 10.1016/j.chom.2008.07.008. Cell Host Microbe. 2008. PMID: 18779052 Free PMC article.
Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides.
McGuigan C, Bourdin C, Derudas M, Hamon N, Hinsinger K, Kandil S, Madela K, Meneghesso S, Pertusati F, Serpi M, Slusarczyk M, Chamberlain S, Kolykhalov A, Vernachio J, Vanpouille C, Introini A, Margolis L, Balzarini J. McGuigan C, et al. Among authors: vanpouille c. Eur J Med Chem. 2013;70:326-40. doi: 10.1016/j.ejmech.2013.09.047. Epub 2013 Oct 9. Eur J Med Chem. 2013. PMID: 24177359 Free PMC article.
Virtual Screening of Acyclovir Derivatives as Potential Antiviral Agents: Design, Synthesis, and Biological Evaluation of New Acyclic Nucleoside ProTides.
Derudas M, Vanpouille C, Carta D, Zicari S, Andrei G, Snoeck R, Brancale A, Margolis L, Balzarini J, McGuigan C. Derudas M, et al. Among authors: vanpouille c. J Med Chem. 2017 Sep 28;60(18):7876-7896. doi: 10.1021/acs.jmedchem.7b01009. Epub 2017 Sep 19. J Med Chem. 2017. PMID: 28829913 Free PMC article.
Acyclovir: a new use for an old drug.
Vanpouille C, Lisco A, Margolis L. Vanpouille C, et al. Curr Opin Infect Dis. 2009 Dec;22(6):583-7. doi: 10.1097/QCO.0b013e32833229b8. Curr Opin Infect Dis. 2009. PMID: 19726982 Review.
Exploiting the anti-HIV-1 activity of acyclovir: suppression of primary and drug-resistant HIV isolates and potentiation of the activity by ribavirin.
Vanpouille C, Lisco A, Introini A, Grivel JC, Munawwar A, Merbah M, Schinazi RF, Derudas M, McGuigan C, Balzarini J, Margolis L. Vanpouille C, et al. Antimicrob Agents Chemother. 2012 May;56(5):2604-11. doi: 10.1128/AAC.05986-11. Epub 2012 Feb 6. Antimicrob Agents Chemother. 2012. PMID: 22314523 Free PMC article.
HSV-2 suppression and the incidence of HIV.
Lisco A, Vanpouille C. Lisco A, et al. Among authors: vanpouille c. N Engl J Med. 2008 Jul 31;359(5):535; author reply 535. doi: 10.1056/NEJMc081075. N Engl J Med. 2008. PMID: 18669436 No abstract available.
Coinfecting viruses as determinants of HIV disease.
Lisco A, Vanpouille C, Margolis L. Lisco A, et al. Among authors: vanpouille c. Curr HIV/AIDS Rep. 2009 Feb;6(1):5-12. doi: 10.1007/s11904-009-0002-3. Curr HIV/AIDS Rep. 2009. PMID: 19149991 Free PMC article. Review.
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