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Human osteosarcoma expresses specific ephrin profiles: implications for tumorigenicity and prognosis.
Varelias A, Koblar SA, Cowled PA, Carter CD, Clayer M. Varelias A, et al. Cancer. 2002 Aug 15;95(4):862-9. doi: 10.1002/cncr.10749. Cancer. 2002. PMID: 12209731
A second mRNA profile that included ephrin-A3, ephrin-A5, and ephrin-B1 was expressed by a subset of tumors. The expression of ephrin-B1 was correlated with a poorer clinical prognosis. ...CONCLUSIONS: The results of this study suggest that ephrin-B1 expresse
A second mRNA profile that included ephrin-A3, ephrin-A5, and ephrin-B1 was expressed by a subset of tumors. The expression of
Up-regulation of MMP-2 and MMP-9 leads to degradation of type IV collagen during skeletal muscle reperfusion injury; protection by the MMP inhibitor, doxycycline.
Roach DM, Fitridge RA, Laws PE, Millard SH, Varelias A, Cowled PA. Roach DM, et al. Eur J Vasc Endovasc Surg. 2002 Mar;23(3):260-9. doi: 10.1053/ejvs.2002.1598. Eur J Vasc Endovasc Surg. 2002. PMID: 11914015
METHODS: rats were anaesthetised and a tourniquet applied to the proximal thigh to occlude blood flow. Four hours of ischaemia was followed by reperfusion for 0, 4, 24 or 72 h. ...Doxycycline-treated rats showed significant preservation of type IV collagen in skeletal musc …
METHODS: rats were anaesthetised and a tourniquet applied to the proximal thigh to occlude blood flow. Four hours of ischaemia was fo …
Regulation of MAPK activation, AP-1 transcription factor expression and keratinocyte differentiation in wounded fetal skin.
Gangnuss S, Cowin AJ, Daehn IS, Hatzirodos N, Rothnagel JA, Varelias A, Rayner TE. Gangnuss S, et al. J Invest Dermatol. 2004 Mar;122(3):791-804. doi: 10.1111/j.0022-202X.2004.22319.x. J Invest Dermatol. 2004. PMID: 15086567
Fetal epithelium retains the ability to re-epithelialize a wound in organotypic culture in a manner not dependent on the presence of underlying dermal substrata. ...Moreover, wounds created in E(17) fetuses in utero heal in a regenerative, scar-free fashion. …
Fetal epithelium retains the ability to re-epithelialize a wound in organotypic culture in a manner not dependent on the prese …
Mitogenic bovine whey extract modulates matrix metalloproteinase-2, -9, and tissue inhibitor of matrix metalloproteinase-2 levels in chronic leg ulcers.
Varelias A, Cowin AJ, Adams D, Harries RH, Cooter RD, Belford DA, Fitridge RA, Rayner TE. Varelias A, et al. Wound Repair Regen. 2006 Jan-Feb;14(1):28-37. doi: 10.1111/j.1743-6109.2005.00085.x. Wound Repair Regen. 2006. PMID: 16476069 Clinical Trial.
We investigated whether a mitogenic bovine whey extract enriched with growth factors modulated the expression and activity of MMP-2 and -9, and the tissue inhibitor of MMP-2 (TIMP-2) in chronic leg ulcers. ...In contrast, a transient increase in the number of MMP-9- …
We investigated whether a mitogenic bovine whey extract enriched with growth factors modulated the expression and activity of MMP-2 a …
Sodium butyrate induced keratinocyte apoptosis.
Daehn IS, Varelias A, Rayner TE. Daehn IS, et al. Apoptosis. 2006 Aug;11(8):1379-90. doi: 10.1007/s10495-006-7960-3. Apoptosis. 2006. PMID: 16761108
In the present study, the effect of sodium butyrate, a histone deacetylase inhibitor, on keratinocyte apoptosis was investigated using the HaCaT human keratinocyte cell line. ...Annexin V staining demonstrated that sodium butyrate induced apoptosis in a dose and tim …
In the present study, the effect of sodium butyrate, a histone deacetylase inhibitor, on keratinocyte apoptosis was investigated usin …
Statins inhibit neutrophil infiltration in skeletal muscle reperfusion injury.
Cowled PA, Khanna A, Laws PE, Field JB, Varelias A, Fitridge RA. Cowled PA, et al. J Surg Res. 2007 Aug;141(2):267-76. doi: 10.1016/j.jss.2006.11.021. Epub 2007 Jun 7. J Surg Res. 2007. PMID: 17559881
Although statins are protective against myocardial IRI and stroke, a role for statins in ameliorating skeletal muscle IRI has not yet been confirmed. ...Nitric oxide also plays a cytotoxic, rather than protective, role in mediating IRI in this model....
Although statins are protective against myocardial IRI and stroke, a role for statins in ameliorating skeletal muscle IRI has not yet …
T-lymphocyte-induced, Fas-mediated apoptosis is associated with early keratinocyte differentiation.
Daehn IS, Varelias A, Rayner TE. Daehn IS, et al. Exp Dermatol. 2010 Apr;19(4):372-80. doi: 10.1111/j.1600-0625.2009.00917.x. Epub 2009 Jul 23. Exp Dermatol. 2010. PMID: 19645855
The development of eczematous lesions is thought to be due in part to a breakdown in skin barrier function as a result of T lymphocytes (T cells) invading the skin causing epidermal keratinocyte apoptosis. ...This observation was accompanied by a marked incre …
The development of eczematous lesions is thought to be due in part to a breakdown in skin barrier function as a result of T ly …
Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease.
Koyama M, Cheong M, Markey KA, Gartlan KH, Kuns RD, Locke KR, Lineburg KE, Teal BE, Leveque-El Mouttie L, Bunting MD, Vuckovic S, Zhang P, Teng MW, Varelias A, Tey SK, Wockner LF, Engwerda CR, Smyth MJ, Belz GT, McColl SR, MacDonald KP, Hill GR. Koyama M, et al. J Exp Med. 2015 Jul 27;212(8):1303-21. doi: 10.1084/jem.20150329. Epub 2015 Jul 13. J Exp Med. 2015. PMID: 26169940 Free PMC article.
These data identify a critical, anatomically distinct, donor DC subset that amplifies GVHD. We thus highlight multiple therapeutic targets and the ability of GVHD, once initiated by recipient antigen-presenting cells, to generate a profound, localized, and lethal fe …
These data identify a critical, anatomically distinct, donor DC subset that amplifies GVHD. We thus highlight multiple therapeutic ta …
Donor treatment with a multipegylated G-CSF maximizes graft-versus-leukemia effects.
Banovic T, MacDonald KP, Markey KA, Morris ES, Kuns RD, Varelias A, Hill GR. Banovic T, et al. Biol Blood Marrow Transplant. 2009 Jan;15(1):126-30. doi: 10.1016/j.bbmt.2008.11.019. Biol Blood Marrow Transplant. 2009. PMID: 19135951
We have compared G-CSF bound to a single PEG molecule (monopeg-G-CSF) as used clinically to a G-CSF molecule bound to multiple PEG molecules (multipeg-G-CSF) in major histocompatibility complex (MHC) disparate and matched models of graft-versus-host disease (GVHD) a …
We have compared G-CSF bound to a single PEG molecule (monopeg-G-CSF) as used clinically to a G-CSF molecule bound to multiple …
Type I-IFNs control GVHD and GVL responses after transplantation.
Robb RJ, Kreijveld E, Kuns RD, Wilson YA, Olver SD, Don AL, Raffelt NC, De Weerd NA, Lineburg KE, Varelias A, Markey KA, Koyama M, Clouston AD, Hertzog PJ, Macdonald KP, Hill GR. Robb RJ, et al. Blood. 2011 Sep 22;118(12):3399-409. doi: 10.1182/blood-2010-12-325746. Epub 2011 Jun 30. Blood. 2011. PMID: 21719602
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