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54 results
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Thalidomide-induced limb defects: resolving a 50-year-old puzzle.
Vargesson N. Vargesson N. Bioessays. 2009 Dec;31(12):1327-36. doi: 10.1002/bies.200900103. Bioessays. 2009. PMID: 19921660 Review.
Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation.
Therapontos C, Erskine L, Gardner ER, Figg WD, Vargesson N. Therapontos C, et al. Among authors: vargesson n. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8573-8. doi: 10.1073/pnas.0901505106. Epub 2009 May 11. Proc Natl Acad Sci U S A. 2009. PMID: 19433787 Free PMC article.
Molecular analysis of regulative events in the developing chick limb.
Mahony C, Vargesson N. Mahony C, et al. Among authors: vargesson n. J Anat. 2013 Jul;223(1):1-13. doi: 10.1111/joa.12060. Epub 2013 May 16. J Anat. 2013. PMID: 23678942 Free PMC article.
Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro.
Mahony C, Erskine L, Niven J, Greig NH, Figg WD, Vargesson N. Mahony C, et al. Among authors: vargesson n. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12703-8. doi: 10.1073/pnas.1307684110. Epub 2013 Jul 15. Proc Natl Acad Sci U S A. 2013. PMID: 23858438 Free PMC article.
Thalidomide-induced teratogenesis: history and mechanisms.
Vargesson N. Vargesson N. Birth Defects Res C Embryo Today. 2015 Jun;105(2):140-56. doi: 10.1002/bdrc.21096. Epub 2015 Jun 4. Birth Defects Res C Embryo Today. 2015. PMID: 26043938 Free PMC article. Review.
Anticancer Properties of a Novel Class of Tetrafluorinated Thalidomide Analogues.
Beedie SL, Peer CJ, Pisle S, Gardner ER, Mahony C, Barnett S, Ambrozak A, G├╝tschow M, Chau CH, Vargesson N, Figg WD. Beedie SL, et al. Among authors: vargesson n. Mol Cancer Ther. 2015 Oct;14(10):2228-37. doi: 10.1158/1535-7163.MCT-15-0320. Epub 2015 Aug 12. Mol Cancer Ther. 2015. PMID: 26269604 Free PMC article.
In vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems.
Beedie SL, Rore HM, Barnett S, Chau CH, Luo W, Greig NH, Figg WD, Vargesson N. Beedie SL, et al. Among authors: vargesson n. Oncotarget. 2016 May 31;7(22):33237-45. doi: 10.18632/oncotarget.8909. Oncotarget. 2016. PMID: 27120781 Free PMC article.
Shared mechanism of teratogenicity of anti-angiogenic drugs identified in the chicken embryo model.
Beedie SL, Mahony C, Walker HM, Chau CH, Figg WD, Vargesson N. Beedie SL, et al. Among authors: vargesson n. Sci Rep. 2016 Jul 22;6:30038. doi: 10.1038/srep30038. Sci Rep. 2016. PMID: 27443489 Free PMC article.
Arterial dysgenesis and limb defects: Clinical and experimental examples.
Vargesson N, Hootnick DR. Vargesson N, et al. Reprod Toxicol. 2017 Jun;70:21-29. doi: 10.1016/j.reprotox.2016.10.005. Epub 2016 Oct 20. Reprod Toxicol. 2017. PMID: 27773741 Review.
A new mammalian model system for thalidomide teratogenesis: Monodelphis domestica.
Sorensen D, Sackett A, Urban DJ, Maier J, Vargesson N, Sears KE. Sorensen D, et al. Among authors: vargesson n. Reprod Toxicol. 2017 Jun;70:126-132. doi: 10.1016/j.reprotox.2017.01.010. Epub 2017 Jan 24. Reprod Toxicol. 2017. PMID: 28130151
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