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Optimization and in Vivo Validation of Peptide Vectors Targeting the LDL Receptor.
Jacquot G, Lécorché P, Malcor JD, Laurencin M, Smirnova M, Varini K, Malicet C, Gassiot F, Abouzid K, Faucon A, David M, Gaudin N, Masse M, Ferracci G, Dive V, Cisternino S, Khrestchatisky M. Jacquot G, et al. Among authors: varini k. Mol Pharm. 2016 Dec 5;13(12):4094-4105. doi: 10.1021/acs.molpharmaceut.6b00687. Epub 2016 Oct 11. Mol Pharm. 2016. PMID: 27656777
Identification and characterization of highly versatile peptide-vectors that bind non-competitively to the low-density lipoprotein receptor for in vivo targeting and delivery of small molecules and protein cargos.
David M, Lécorché P, Masse M, Faucon A, Abouzid K, Gaudin N, Varini K, Gassiot F, Ferracci G, Jacquot G, Vlieghe P, Khrestchatisky M. David M, et al. Among authors: varini k. PLoS One. 2018 Feb 27;13(2):e0191052. doi: 10.1371/journal.pone.0191052. eCollection 2018. PLoS One. 2018. PMID: 29485998 Free PMC article.
Target engagement and intracellular delivery of mono- and bivalent LDL receptor-binding peptide-cargo conjugates: Implications for the rational design of new targeted drug therapies.
Varini K, Lécorché P, Sonnette R, Gassiot F, Broc B, Godard M, David M, Faucon A, Abouzid K, Ferracci G, Temsamani J, Khrestchatisky M, Jacquot G. Varini K, et al. J Control Release. 2019 Nov 28;314:141-161. doi: 10.1016/j.jconrel.2019.10.033. Epub 2019 Oct 20. J Control Release. 2019. PMID: 31644939
The food-associated fungal neurotoxin ochratoxin A inhibits the absorption of glutamate by astrocytes through a decrease in cell surface expression of the excitatory amino-acid transporters GLAST and GLT-1.
Razafimanjato H, Garmy N, Guo XJ, Varini K, Di Scala C, Di Pasquale E, Taïeb N, Maresca M. Razafimanjato H, et al. Among authors: varini k. Neurotoxicology. 2010 Sep;31(5):475-84. doi: 10.1016/j.neuro.2010.06.003. Epub 2010 Jun 15. Neurotoxicology. 2010. PMID: 20558201