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Sequencing the chimpanzee genome: insights into human evolution and disease.
Olson MV, Varki A. Olson MV, et al. Among authors: varki a. Nat Rev Genet. 2003 Jan;4(1):20-8. doi: 10.1038/nrg981. Nat Rev Genet. 2003. PMID: 12509750 Review.
First, the discovery of functionally important mutations that are specific to the human lineage offers a new path towards medical benefits. ...
First, the discovery of functionally important mutations that are specific to the human lineage offers a new path towards medical ben …
A chimpanzee genome project is a biomedical imperative.
Varki A. Varki A. Genome Res. 2000 Aug;10(8):1065-70. doi: 10.1101/gr.10.8.1065. Genome Res. 2000. PMID: 10958623 Review. No abstract available.
Fixation of the human-specific CMP-N-acetylneuraminic acid hydroxylase pseudogene and implications of haplotype diversity for human evolution.
Hayakawa T, Aki I, Varki A, Satta Y, Takahata N. Hayakawa T, et al. Among authors: varki a. Genetics. 2006 Feb;172(2):1139-46. doi: 10.1534/genetics.105.046995. Epub 2005 Nov 4. Genetics. 2006. PMID: 16272417 Free PMC article.
We analyzed a 7.3-kb intronic region of 132 CMAH genes to explore the fixation process of this pseudogene and the demographic implication of its haplotype diversity. ...Although population structure within Africa complicates the interpretation of phylogeographic informatio …
We analyzed a 7.3-kb intronic region of 132 CMAH genes to explore the fixation process of this pseudogene and the demographic implica …
Evolution of human-chimpanzee differences in malaria susceptibility: relationship to human genetic loss of N-glycolylneuraminic acid.
Martin MJ, Rayner JC, Gagneux P, Barnwell JW, Varki A. Martin MJ, et al. Among authors: varki a. Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12819-24. doi: 10.1073/pnas.0503819102. Epub 2005 Aug 26. Proc Natl Acad Sci U S A. 2005. PMID: 16126901 Free PMC article.
Plasmodium reichenowi, a morphologically identical and genetically very similar parasite, infects chimpanzees but not humans. ...These results also have implications for the prehistory of hominids and for the genetic origins and recent emergence of P. falciparum as a
Plasmodium reichenowi, a morphologically identical and genetically very similar parasite, infects chimpanzees but not humans. ...Thes …
Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution.
Chou HH, Hayakawa T, Diaz S, Krings M, Indriati E, Leakey M, Paabo S, Satta Y, Takahata N, Varki A. Chou HH, et al. Among authors: varki a. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11736-41. doi: 10.1073/pnas.182257399. Epub 2002 Aug 21. Proc Natl Acad Sci U S A. 2002. PMID: 12192086 Free PMC article.
First, we have developed a method to extract and identify sialic acids from bones and bony fossils. Two Neanderthal fossils studied had clearly detectable Neu5Ac but no Neu5Gc, indicating that the CMAH mutation predated the common ancestor of humans and the Neanderthal, ap …
First, we have developed a method to extract and identify sialic acids from bones and bony fossils. Two Neanderthal fossils studied h …
Comparing the human and chimpanzee genomes: searching for needles in a haystack.
Varki A, Altheide TK. Varki A, et al. Genome Res. 2005 Dec;15(12):1746-58. doi: 10.1101/gr.3737405. Genome Res. 2005. PMID: 16339373 Review.
The chimpanzee genome sequence is a long-awaited milestone, providing opportunities to explore primate evolution and genetic contributions to human physiology and disease. Humans and chimpanzees shared a common ancestor approximately 5-7 million years ago (Mya). The …
The chimpanzee genome sequence is a long-awaited milestone, providing opportunities to explore primate evolution and genetic contribu …
Genomics. The chimpanzee genome--a bittersweet celebration.
Olson MV, Varki A. Olson MV, et al. Among authors: varki a. Science. 2004 Jul 9;305(5681):191-2. doi: 10.1126/science.1100975. Science. 2004. PMID: 15247465 No abstract available.
Evolution of genetic and genomic features unique to the human lineage.
O'Bleness M, Searles VB, Varki A, Gagneux P, Sikela JM. O'Bleness M, et al. Among authors: varki a. Nat Rev Genet. 2012 Dec;13(12):853-66. doi: 10.1038/nrg3336. Nat Rev Genet. 2012. PMID: 23154808 Free PMC article. Review.
Given the unprecedented tools that are now available for rapidly comparing genomes, the identification and study of genetic and genomic changes that are unique to our species have accelerated, and we are entering a golden age of human evolutionary genomics. ...
Given the unprecedented tools that are now available for rapidly comparing genomes, the identification and study of genetic and genomic chan …
Explaining human uniqueness: genome interactions with environment, behaviour and culture.
Varki A, Geschwind DH, Eichler EE. Varki A, et al. Nat Rev Genet. 2008 Oct;9(10):749-63. doi: 10.1038/nrg2428. Nat Rev Genet. 2008. PMID: 18802414 Free PMC article. Review.
In fact, 'anthropogeny' (explaining the origin of humans) requires a transdisciplinary approach that eschews such barriers. Here we take a genomic and genetic perspective towards molecular variation, explore systems analysis of gene expression and discuss an organ-s …
In fact, 'anthropogeny' (explaining the origin of humans) requires a transdisciplinary approach that eschews such barriers. Here we t …
How to make an ape brain.
Varki A. Varki A. Nat Genet. 2004 Oct;36(10):1034-6. doi: 10.1038/ng1004-1034. Nat Genet. 2004. PMID: 15454937 No abstract available.
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