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Siglecs and their roles in the immune system.
Crocker PR, Paulson JC, Varki A. Crocker PR, et al. Among authors: varki a. Nat Rev Immunol. 2007 Apr;7(4):255-66. doi: 10.1038/nri2056. Nat Rev Immunol. 2007. PMID: 17380156 Review.
Cell surfaces in the immune system are richly equipped with a complex mixture of glycans, which can be recognized by diverse glycan-binding proteins. The Siglecs are a family of sialic-acid-binding immunoglobulin-like lectins that are thought to promote cell-cell in …
Cell surfaces in the immune system are richly equipped with a complex mixture of glycans, which can be recognized by diverse glycan-b …
Siglecs, sialic acids and innate immunity.
Crocker PR, Varki A. Crocker PR, et al. Among authors: varki a. Trends Immunol. 2001 Jun;22(6):337-42. doi: 10.1016/s1471-4906(01)01930-5. Trends Immunol. 2001. PMID: 11377294 Review.
Since then, a further six human CD33-related Siglecs with features of inhibitory receptors have been identified and shown to be expressed by discrete subsets of leukocytes. Recognition of Sia by these Siglecs could play a role in the regulation of the innate immune …
Since then, a further six human CD33-related Siglecs with features of inhibitory receptors have been identified and shown to be expre …
Siglecs in the immune system.
Crocker PR, Varki A. Crocker PR, et al. Among authors: varki a. Immunology. 2001 Jun;103(2):137-45. doi: 10.1046/j.0019-2805.2001.01241.x. Immunology. 2001. PMID: 11412300 Free PMC article. Review. No abstract available.
Tamm-Horsfall glycoprotein engages human Siglec-9 to modulate neutrophil activation in the urinary tract.
Patras KA, Coady A, Olson J, Ali SR, RamachandraRao SP, Kumar S, Varki A, Nizet V. Patras KA, et al. Among authors: varki a. Immunol Cell Biol. 2017 Nov;95(10):960-965. doi: 10.1038/icb.2017.63. Epub 2017 Aug 22. Immunol Cell Biol. 2017. PMID: 28829050 Free PMC article.
Urinary tract infections are a major problem in human medicine for which better understanding of native immune defenses may reveal new pathways for therapeutic intervention. ...In addition to its well-studied functions to antagonize bacterial colonization, we hypothesize t …
Urinary tract infections are a major problem in human medicine for which better understanding of native immune defenses may reveal ne …
Relative over-reactivity of human versus chimpanzee lymphocytes: implications for the human diseases associated with immune activation.
Soto PC, Stein LL, Hurtado-Ziola N, Hedrick SM, Varki A. Soto PC, et al. Among authors: varki a. J Immunol. 2010 Apr 15;184(8):4185-95. doi: 10.4049/jimmunol.0903420. Epub 2010 Mar 15. J Immunol. 2010. PMID: 20231688 Free PMC article.
In this study, we show that human T cells are more reactive than chimpanzee T cells to a wide variety of stimuli, including anti-TCR Abs of multiple isotypes, l-phytohemagglutin, Staphylococcus aureus superantigen, a superagonist anti-CD28 Ab, and in MLRs. ...Thus, …
In this study, we show that human T cells are more reactive than chimpanzee T cells to a wide variety of stimuli, including anti-TCR …
Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer.
Läubli H, Pearce OM, Schwarz F, Siddiqui SS, Deng L, Stanczak MA, Deng L, Verhagen A, Secrest P, Lusk C, Schwartz AG, Varki NM, Bui JD, Varki A. Läubli H, et al. Among authors: varki nm, varki a. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14211-6. doi: 10.1073/pnas.1409580111. Epub 2014 Sep 15. Proc Natl Acad Sci U S A. 2014. PMID: 25225409 Free PMC article.
Supporting this hypothesis, Siglec-9-expressing myelomonocytic cells found in human tumor samples were accompanied by a strong up-regulation of Siglec-9 ligands. ...In keeping with this, Siglec-E-deficient macrophages showed a propensity toward a tumor-promot …
Supporting this hypothesis, Siglec-9-expressing myelomonocytic cells found in human tumor samples were accompanied by a strong up-reg …
Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils.
Zhang M, Angata T, Cho JY, Miller M, Broide DH, Varki A. Zhang M, et al. Among authors: varki a. Blood. 2007 May 15;109(10):4280-7. doi: 10.1182/blood-2006-08-039255. Epub 2007 Feb 1. Blood. 2007. PMID: 17272508 Free PMC article.
CD33-related Siglecs (CD33rSiglecs) are a family of sialic acid-recognizing lectins on immune cells whose biologic functions are unknown. ...Taken together with the tyrosine-based inhibitory motif in the cytosolic tail of Siglec-F, the data suggested a negative feed …
CD33-related Siglecs (CD33rSiglecs) are a family of sialic acid-recognizing lectins on immune cells whose biologic functions are unkn …
Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes.
Carlin AF, Lewis AL, Varki A, Nizet V. Carlin AF, et al. Among authors: varki a. J Bacteriol. 2007 Feb;189(4):1231-7. doi: 10.1128/JB.01155-06. Epub 2006 Sep 22. J Bacteriol. 2007. PMID: 16997964 Free PMC article.
We hypothesized that GBS evolved to display CPS Sia as a form of molecular mimicry limiting the activation of an effective innate immune response. In this study, we applied a panel of immunologic and cell-based assays to demonstrate that GBS of several serotypes int …
We hypothesized that GBS evolved to display CPS Sia as a form of molecular mimicry limiting the activation of an effective innate imm …
System-wide genomic and biochemical comparisons of sialic acid biology among primates and rodents: Evidence for two modes of rapid evolution.
Altheide TK, Hayakawa T, Mikkelsen TS, Diaz S, Varki N, Varki A. Altheide TK, et al. Among authors: varki n, varki a. J Biol Chem. 2006 Sep 1;281(35):25689-702. doi: 10.1074/jbc.M604221200. Epub 2006 Jun 12. J Biol Chem. 2006. PMID: 16769723
However, they should be evaluated together from functional and evolutionary perspectives in a "biochemical systems" approach, considering each monosaccharide unit's biosynthesis, activation, transport, modification, transfer, recycling, degradation, and recognition. ...The …
However, they should be evaluated together from functional and evolutionary perspectives in a "biochemical systems" approach, conside …
Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates.
Padler-Karavani V, Hurtado-Ziola N, Chang YC, Sonnenburg JL, Ronaghy A, Yu H, Verhagen A, Nizet V, Chen X, Varki N, Varki A, Angata T. Padler-Karavani V, et al. Among authors: varki n, varki a. FASEB J. 2014 Mar;28(3):1280-93. doi: 10.1096/fj.13-241497. Epub 2013 Dec 5. FASEB J. 2014. PMID: 24308974 Free PMC article.
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