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The degradation signal in a short-lived protein.
Bachmair A, Varshavsky A. Bachmair A, et al. Among authors: varshavsky a. Cell. 1989 Mar 24;56(6):1019-32. doi: 10.1016/0092-8674(89)90635-1. Cell. 1989. PMID: 2538246
Our previous work has shown that the amino-terminal residue of a short-lived protein is a distinct component of the protein's degradation signal. ...The mechanistic significance of the second determinant is illuminated by the finding that in a targeted, short …
Our previous work has shown that the amino-terminal residue of a short-lived protein is a distinct component of the protein's …
Ubiquitin as a degradation signal.
Johnson ES, Bartel B, Seufert W, Varshavsky A. Johnson ES, et al. Among authors: varshavsky a. EMBO J. 1992 Feb;11(2):497-505. EMBO J. 1992. PMID: 1311250 Free PMC article.
For many short-lived eukaryotic proteins, conjugation to ubiquitin, yielding a multiubiquitin chain, is an obligatory pre-degradation step. The conjugated ubiquitin moieties function as a 'secondary' signal for degradation, in that their posttranslational coupling t …
For many short-lived eukaryotic proteins, conjugation to ubiquitin, yielding a multiubiquitin chain, is an obligatory pre-degradation …
The N-end rule.
Varshavsky A. Varshavsky A. Cell. 1992 May 29;69(5):725-35. doi: 10.1016/0092-8674(92)90285-k. Cell. 1992. PMID: 1317266 Review. No abstract available.
Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP gene family.
Baker RT, Tobias JW, Varshavsky A. Baker RT, et al. Among authors: varshavsky a. J Biol Chem. 1992 Nov 15;267(32):23364-75. J Biol Chem. 1992. PMID: 1429680
A gene encoding a putative tyrosine phosphatase suppresses lethality of an N-end rule-dependent mutant.
Ota IM, Varshavsky A. Ota IM, et al. Among authors: varshavsky a. Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2355-9. doi: 10.1073/pnas.89.6.2355. Proc Natl Acad Sci U S A. 1992. PMID: 1549598 Free PMC article.
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. In the yeast Saccharomyces cerevisiae, mutational inactivation of the N-end rule pathway is neither lethal nor phenotypically conspicuous. We have used a "synthetic …
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. In the yeast Saccharomyces cerev …
The short-lived MAT alpha 2 transcriptional regulator is ubiquitinated in vivo.
Hochstrasser M, Ellison MJ, Chau V, Varshavsky A. Hochstrasser M, et al. Among authors: varshavsky a. Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4606-10. doi: 10.1073/pnas.88.11.4606. Proc Natl Acad Sci U S A. 1991. PMID: 1647011 Free PMC article.
More than one lysine residue of alpha 2 can be joined to ubiquitin, and some of the ubiquitin moieties form a Lys48-linked multiubiquitin chain. Overexpression of degradation-impaired ubiquitin variants was used to show that at least a significant fraction of alpha …
More than one lysine residue of alpha 2 can be joined to ubiquitin, and some of the ubiquitin moieties form a Lys48-linked multiubiqu …
The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme.
Dohmen RJ, Madura K, Bartel B, Varshavsky A. Dohmen RJ, et al. Among authors: varshavsky a. Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7351-5. doi: 10.1073/pnas.88.16.7351. Proc Natl Acad Sci U S A. 1991. PMID: 1651502 Free PMC article.
The N-end rule relates the in vivo half-life of a protein to the identity of its amino-terminal residue. Distinct versions of the N-end rule operate in all organisms examined, from mammals to bacteria. ...
The N-end rule relates the in vivo half-life of a protein to the identity of its amino-terminal residue. Distinct versions of the N-e …
Inhibition of the N-end rule pathway in living cells.
Baker RT, Varshavsky A. Baker RT, et al. Among authors: varshavsky a. Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1090-4. doi: 10.1073/pnas.88.4.1090. Proc Natl Acad Sci U S A. 1991. PMID: 1899923 Free PMC article.
The N-end rule relates the metabolic stability of a protein to the identify of its amino-terminal residue. Previous work, using amino acid derivatives such as dipeptides to inhibit N-end rule-mediated protein degradation in an extract from mammalian reticulocytes, has demo …
The N-end rule relates the metabolic stability of a protein to the identify of its amino-terminal residue. Previous work, using amino …
The N-end rule in bacteria.
Tobias JW, Shrader TE, Rocap G, Varshavsky A. Tobias JW, et al. Among authors: varshavsky a. Science. 1991 Nov 29;254(5036):1374-7. doi: 10.1126/science.1962196. Science. 1991. PMID: 1962196
The N-end rule relates the in vivo half-life of a protein to the identity of its amino-terminal residue. Distinct versions of the N-end rule operate in all eukaryotes examined. ...Amino-terminal arginine, lysine, leucine, phenylalanine, tyrosine, and tryptophan confer 2-mi …
The N-end rule relates the in vivo half-life of a protein to the identity of its amino-terminal residue. Distinct versions of the N-e …
Naming a targeting signal.
Varshavsky A. Varshavsky A. Cell. 1991 Jan 11;64(1):13-5. doi: 10.1016/0092-8674(91)90202-a. Cell. 1991. PMID: 1986863 No abstract available.
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