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Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85.
Ciechanover A, Finley D, Varshavsky A. Ciechanover A, et al. Among authors: varshavsky a. Cell. 1984 May;37(1):57-66. doi: 10.1016/0092-8674(84)90300-3. Cell. 1984. PMID: 6327060
We have shown that covalent conjugation of ubiquitin to proteins is temperature-sensitive in the mouse cell cycle mutant ts85 due to a specifically thermolabile ubiquitin-activating enzyme (accompanying paper). ...Immunochemical analysis shows a strong and specific …
We have shown that covalent conjugation of ubiquitin to proteins is temperature-sensitive in the mouse cell cycle mutant ts85 due to a
Nucleosomes and subnucleosomes: heterogeneity and composition.
Bakayev VV, Bakayeva TG, Varshavsky AJ. Bakayev VV, et al. Among authors: varshavsky aj. Cell. 1977 Jul;11(3):619-29. doi: 10.1016/0092-8674(77)90079-4. Cell. 1977. PMID: 884737 No abstract available.
Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85.
Finley D, Ciechanover A, Varshavsky A. Finley D, et al. Among authors: varshavsky a. Cell. 1984 May;37(1):43-55. doi: 10.1016/0092-8674(84)90299-x. Cell. 1984. PMID: 6327059
Ubiquitin, a 76 residue protein, occurs in eucaryotic cells either free or covalently joined to a variety of protein species. Previous work suggested that ubiquitin may function as a signal for attack by proteinases specific for ubiquitin-protein conjugates. …
Ubiquitin, a 76 residue protein, occurs in eucaryotic cells either free or covalently joined to a variety of protein species. …
In vivo degradation of a transcriptional regulator: the yeast alpha 2 repressor.
Hochstrasser M, Varshavsky A. Hochstrasser M, et al. Among authors: varshavsky a. Cell. 1990 May 18;61(4):697-708. doi: 10.1016/0092-8674(90)90481-s. Cell. 1990. PMID: 2111732
Each of the two structural domains of alpha 2 carries a sequence that can independently target a normally long-lived protein for rapid destruction. ...This subunit-specific degradation makes possible a novel type of posttranslational remodeling in which a
Each of the two structural domains of alpha 2 carries a sequence that can independently target a normally long-lived protein f …
A protein binds to a satellite DNA repeat at three specific sites that would be brought into mutual proximity by DNA folding in the nucleosome.
Strauss F, Varshavsky A. Strauss F, et al. Among authors: varshavsky a. Cell. 1984 Jul;37(3):889-901. doi: 10.1016/0092-8674(84)90424-0. Cell. 1984. PMID: 6540146
Using a generally applicable assay for specific DNA-binding proteins in crude extracts, we have detected and purified an HMG-like nuclear protein from African green monkey cells that preferentially binds to the 172 bp repeat of alpha-satellite DNA (alpha-DNA). ...Our resul …
Using a generally applicable assay for specific DNA-binding proteins in crude extracts, we have detected and purified an HMG-like nuc …
Selective arrangement of ubiquitinated and D1 protein-containing nucleosomes within the Drosophila genome.
Levinger L, Varshavsky A. Levinger L, et al. Among authors: varshavsky a. Cell. 1982 Feb;28(2):375-85. doi: 10.1016/0092-8674(82)90355-5. Cell. 1982. PMID: 6277512
We have a new approach, two-dimensional hybridization mapping of nucleosomes, to compare the structures of mononucleosomes from different regions of the Drosophila melanogaster genome. Approximately one in two nucleosomes of the transcribed copia and heat-shock 70 (hsp 70) …
We have a new approach, two-dimensional hybridization mapping of nucleosomes, to compare the structures of mononucleosomes from diffe …
Mammalian cell cycle mutant defective in intracellular protein degradation and ubiquitin-protein conjugation.
Ciechanover A, Finley D, Varshavsky A. Ciechanover A, et al. Among authors: varshavsky a. Prog Clin Biol Res. 1985;180:17-31. Prog Clin Biol Res. 1985. PMID: 2994083
Ubiquitin, a 76 residue protein, occurs in eukaryotic cells either free or covalently joined via its carboxyl terminus to epsilon-amino groups of lysine residues in a wide variety of protein species. Previous work has shown that ubiquitin-protein conjugates are pref …
Ubiquitin, a 76 residue protein, occurs in eukaryotic cells either free or covalently joined via its carboxyl terminus to epsilon-ami …
The ubiquitin-mediated proteolytic pathway and mechanisms of energy-dependent intracellular protein degradation.
Ciechanover A, Finley D, Varshavsky A. Ciechanover A, et al. Among authors: varshavsky a. J Cell Biochem. 1984;24(1):27-53. doi: 10.1002/jcb.240240104. J Cell Biochem. 1984. PMID: 6327743 Review.
The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses.
Finley D, Ozkaynak E, Varshavsky A. Finley D, et al. Among authors: varshavsky a. Cell. 1987 Mar 27;48(6):1035-46. doi: 10.1016/0092-8674(87)90711-2. Cell. 1987. PMID: 3030556
The fourth gene, UBI4, contains five ubiquitin-coding elements in a head-to-tail arrangement, and thus encodes a polyubiquitin precursor protein. ...However, although ubi4/UBI4 diploids can form four initially viable spores, the two ubi4 spores within the ascus lose …
The fourth gene, UBI4, contains five ubiquitin-coding elements in a head-to-tail arrangement, and thus encodes a polyubiquitin …
The degradation signal in a short-lived protein.
Bachmair A, Varshavsky A. Bachmair A, et al. Among authors: varshavsky a. Cell. 1989 Mar 24;56(6):1019-32. doi: 10.1016/0092-8674(89)90635-1. Cell. 1989. PMID: 2538246
Our previous work has shown that the amino-terminal residue of a short-lived protein is a distinct component of the protein's degradation signal. ...The mechanistic significance of the second determinant is illuminated by the finding that in a targeted, short …
Our previous work has shown that the amino-terminal residue of a short-lived protein is a distinct component of the protein's …
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