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Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding.
Trapasso F, Krakowiak A, Cesari R, Arkles J, Yendamuri S, Ishii H, Vecchione A, Kuroki T, Bieganowski P, Pace HC, Huebner K, Croce CM, Brenner C. Trapasso F, et al. Among authors: vecchione a. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1592-7. doi: 10.1073/pnas.0437915100. Epub 2003 Feb 6. Proc Natl Acad Sci U S A. 2003. PMID: 12574506 Free PMC article.
Inactivation of the FHIT gene favors bladder cancer development.
Vecchione A, Sevignani C, Giarnieri E, Zanesi N, Ishii H, Cesari R, Fong LY, Gomella LG, Croce CM, Baffa R. Vecchione A, et al. Clin Cancer Res. 2004 Nov 15;10(22):7607-12. doi: 10.1158/1078-0432.CCR-04-0341. Clin Cancer Res. 2004. PMID: 15569992
403 results