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1925 3
1926 1
1928 2
1929 2
1930 3
1931 3
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1933 1
1934 3
1935 3
1936 2
1938 2
1939 2
1940 3
1941 2
1942 1
1943 4
1944 2
1945 7
1946 25
1947 20
1948 16
1949 21
1950 28
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1952 43
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1954 83
1955 43
1956 74
1957 56
1958 70
1959 37
1960 80
1961 97
1962 100
1963 179
1964 240
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1968 457
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1972 563
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1974 413
1975 454
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1981 705
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1983 1011
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1987 2250
1988 2489
1989 3020
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2000 7288
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2004 9610
2005 10292
2006 10521
2007 10543
2008 11138
2009 11491
2010 12069
2011 13154
2012 13575
2013 14083
2014 14645
2015 14902
2016 15382
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2019 16927
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2023 19905
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409,941 results

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Page 1
Developing the next-generation of adenoviral vector vaccines.
Sampson AT, Hlaváč M, Gillman ACT, Douradinha B, Gilbert SC. Sampson AT, et al. Hum Vaccin Immunother. 2025 Dec;21(1):2514356. doi: 10.1080/21645515.2025.2514356. Epub 2025 Jul 1. Hum Vaccin Immunother. 2025. PMID: 40590260 Free PMC article. Review.
The COVID-19 pandemic saw the first extensive use of adenoviral vector vaccines, with over 3 billion doses produced during the first year of the pandemic alone and an estimated 6 million lives saved. ...Despite their successful deployment against SARS-CoV-2, their impact h …
The COVID-19 pandemic saw the first extensive use of adenoviral vector vaccines, with over 3 billion doses produced during the first …
Viral vector-based influenza vaccines.
de Vries RD, Rimmelzwaan GF. de Vries RD, et al. Hum Vaccin Immunother. 2016 Nov;12(11):2881-2901. doi: 10.1080/21645515.2016.1210729. Epub 2016 Jul 25. Hum Vaccin Immunother. 2016. PMID: 27455345 Free PMC article.
The development of game-changing vaccines that induce broadly protective immunity against a wide variety of influenza viruses is an unmet need, in which recombinant viral vectors may provide. Use of viral vectors allows the delivery of any influenza virus antigen, o …
The development of game-changing vaccines that induce broadly protective immunity against a wide variety of influenza viruses is an unmet ne …
Vector-based genetically modified vaccines: Exploiting Jenner's legacy.
Ramezanpour B, Haan I, Osterhaus A, Claassen E. Ramezanpour B, et al. Vaccine. 2016 Dec 7;34(50):6436-6448. doi: 10.1016/j.vaccine.2016.06.059. Epub 2016 Oct 28. Vaccine. 2016. PMID: 28029542 Free PMC article. Review.
Results of this study revealed that vector-based vaccines comprise a significant part of all GM vaccines in the pipeline. This study further highlights that poxviruses and adenoviruses are among the most prominent vectors in GM vaccine development. After the approva …
Results of this study revealed that vector-based vaccines comprise a significant part of all GM vaccines in the pipeline. This study …
The Adenovirus Vector Platform: Novel Insights into Rational Vector Design and Lessons Learned from the COVID-19 Vaccine.
Sallard E, Zhang W, Aydin M, Schröer K, Ehrhardt A. Sallard E, et al. Viruses. 2023 Jan 11;15(1):204. doi: 10.3390/v15010204. Viruses. 2023. PMID: 36680244 Free PMC article. Review.
Over recent years, the adenovirus vector platform has been in the center of attention for vaccine development against the ongoing coronavirus SARS-CoV-2/COVID-19 pandemic. ...This review covers the full spectrum of state-of-the-art strategies to avoid vector-induced …
Over recent years, the adenovirus vector platform has been in the center of attention for vaccine development against the ongoing cor …
Adenoviral vector immunity: its implications and circumvention strategies.
Ahi YS, Bangari DS, Mittal SK. Ahi YS, et al. Curr Gene Ther. 2011 Aug;11(4):307-20. doi: 10.2174/156652311796150372. Curr Gene Ther. 2011. PMID: 21453277 Free PMC article. Review.
However, the presence of preexisting Ad immunity and the rapid development of Ad vector immunity still pose significant challenges to the clinical use of these vectors. ...This review provides an update on our current understanding of immune responses to Ad vecto …
However, the presence of preexisting Ad immunity and the rapid development of Ad vector immunity still pose significant challenges to …
Adeno-associated virus vector integration.
Deyle DR, Russell DW. Deyle DR, et al. Curr Opin Mol Ther. 2009 Aug;11(4):442-7. Curr Opin Mol Ther. 2009. PMID: 19649989 Free PMC article. Review.
Adeno-associated virus (AAV) vectors efficiently transduce various cell types and can produce long-term expression of transgenes in vivo. Although AAV vector genomes can persist within cells as episomes, vector integration has been observed in various experim …
Adeno-associated virus (AAV) vectors efficiently transduce various cell types and can produce long-term expression of transgenes in v …
Managing microRNAs with vector-encoded decoy-type inhibitors.
Bak RO, Hollensen AK, Mikkelsen JG. Bak RO, et al. Mol Ther. 2013 Aug;21(8):1478-85. doi: 10.1038/mt.2013.113. Epub 2013 Jun 11. Mol Ther. 2013. PMID: 23752312 Free PMC article. Review.
Here, we provide an overview of the strategies that have been used to adapt vector-encoded inhibitors for miRNA suppression and discuss advantages related to spatiotemporal and long-term miRNA attenuation. ...The community will aspire to combine circles with high-affinity …
Here, we provide an overview of the strategies that have been used to adapt vector-encoded inhibitors for miRNA suppression and discu …
Adenovirus vector production and purification.
Silva AC, Peixoto C, Lucas T, Küppers C, Cruz PE, Alves PM, Kochanek S. Silva AC, et al. Curr Gene Ther. 2010 Dec;10(6):437-55. doi: 10.2174/156652310793797694. Curr Gene Ther. 2010. PMID: 21054247 Review.
Replication deficient adenovirus vectors are frequently used tools for the delivery of transgenes in vitro and in vivo. In addition, several therapeutic products based on adenovirus are under clinical development. This review outlines adenovirus vector production di …
Replication deficient adenovirus vectors are frequently used tools for the delivery of transgenes in vitro and in vivo. In addition, …
Nonintegrating Gene Therapy Vectors.
Athanasopoulos T, Munye MM, Yáñez-Muñoz RJ. Athanasopoulos T, et al. Hematol Oncol Clin North Am. 2017 Oct;31(5):753-770. doi: 10.1016/j.hoc.2017.06.007. Hematol Oncol Clin North Am. 2017. PMID: 28895845 Free article. Review.
However, unless engineered for replication and segregation, nonintegrating vectors will dilute progressively in proliferating cells, and are not exempt of epigenetic effects. This article provides an overview of the main nonintegrating viral (adenoviral, adeno-associated v …
However, unless engineered for replication and segregation, nonintegrating vectors will dilute progressively in proliferating cells, …
Integrase deficient lentiviral vector: prospects for safe clinical applications.
Yew CT, Gurumoorthy N, Nordin F, Tye GJ, Wan Kamarul Zaman WS, Tan JJ, Ng MH. Yew CT, et al. PeerJ. 2022 Aug 12;10:e13704. doi: 10.7717/peerj.13704. eCollection 2022. PeerJ. 2022. PMID: 35979475 Free PMC article.
HIV-1 derived lentiviral vector is an efficient transporter for delivering desired genetic materials into the targeted cells among many viral vectors. ...Various measures have been administered in different generations of lentiviral vector systems to r …
HIV-1 derived lentiviral vector is an efficient transporter for delivering desired genetic materials into the targeted cells a …
409,941 results
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