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Structure-activity relationships of natural quinone vegfrecine analogs with potent activity against VEGFR-1 and -2 tyrosine kinases.
Adachi H, Nosaka C, Atsumi S, Nakae K, Umezawa Y, Sawa R, Kubota Y, Nakane C, Shibuya M, Nishimura Y. Adachi H, et al. J Antibiot (Tokyo). 2021 Oct;74(10):734-742. doi: 10.1038/s41429-021-00445-y. Epub 2021 Jul 20. J Antibiot (Tokyo). 2021. PMID: 34282315
A series of analogs of vegfrecine, a natural quinone vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor, was synthesized via oxidative amination of 2,5-dihydroxybenzamide with functionalized arylamine followed by ammonolysis and substitution of t …
A series of analogs of vegfrecine, a natural quinone vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor, w …
Vegfrecine, an inhibitor of VEGF receptor tyrosine kinases isolated from the culture broth of Streptomyces sp.
Nosaka C, Adachi H, Sawa R, Nakae K, Atsumi S, Kinoshita N, Kubota Y, Igarashi M, Sei Y, Yamaguchi K, Shibuya M, Nishimura Y, Akamatsu Y. Nosaka C, et al. J Nat Prod. 2013 Apr 26;76(4):715-9. doi: 10.1021/np300535c. Epub 2013 Feb 15. J Nat Prod. 2013. PMID: 23414235
A new inhibitor of VEGF receptor tyrosine kinases, vegfrecine (1), was isolated from the culture broth of Streptomyces sp. MK931-CF8. The molecular structure of 1 was determined by NMR and MS analysis combined with synthesis. ...
A new inhibitor of VEGF receptor tyrosine kinases, vegfrecine (1), was isolated from the culture broth of Streptomyces sp. MK931-CF8. …