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Role of glucocorticoids and the glucocorticoid receptor in metabolism: insights from genetic manipulations.
Rose AJ, Vegiopoulos A, Herzig S. Rose AJ, et al. Among authors: vegiopoulos a. J Steroid Biochem Mol Biol. 2010 Oct;122(1-3):10-20. doi: 10.1016/j.jsbmb.2010.02.010. Epub 2010 Feb 17. J Steroid Biochem Mol Biol. 2010. PMID: 20170729 Review.
Whereas physiological levels of glucocorticoids are required for proper metabolic control, aberrant glucocorticoid action has been linked to a variety of pandemic metabolic diseases, such as type II diabetes and obesity. Based on its importance for human health, studies of …
Whereas physiological levels of glucocorticoids are required for proper metabolic control, aberrant glucocorticoid action has been linked to …
Diet-dependent function of the extracellular matrix proteoglycan Lumican in obesity and glucose homeostasis.
Wolff G, Taranko AE, Meln I, Weinmann J, Sijmonsma T, Lerch S, Heide D, Billeter AT, Tews D, Krunic D, Fischer-Posovszky P, Müller-Stich BP, Herzig S, Grimm D, Heikenwälder M, Kao WW, Vegiopoulos A. Wolff G, et al. Among authors: vegiopoulos a. Mol Metab. 2019 Jan;19:97-106. doi: 10.1016/j.molmet.2018.10.007. Epub 2018 Oct 23. Mol Metab. 2019. PMID: 30409703 Free PMC article.
Transcriptional cofactor TBLR1 controls lipid mobilization in white adipose tissue.
Rohm M, Sommerfeld A, Strzoda D, Jones A, Sijmonsma TP, Rudofsky G, Wolfrum C, Sticht C, Gretz N, Zeyda M, Leitner L, Nawroth PP, Stulnig TM, Berriel Diaz M, Vegiopoulos A, Herzig S. Rohm M, et al. Among authors: vegiopoulos a. Cell Metab. 2013 Apr 2;17(4):575-85. doi: 10.1016/j.cmet.2013.02.010. Epub 2013 Mar 14. Cell Metab. 2013. PMID: 23499424
Indeed, mice lacking TBLR1 in adipocytes are defective in fasting-induced lipid mobilization and, when placed on a high-fat-diet, show aggravated adiposity, glucose intolerance, and insulin resistance. ...As a critical regulator of WAT cAMP signaling and lipid mobil …
Indeed, mice lacking TBLR1 in adipocytes are defective in fasting-induced lipid mobilization and, when placed on a high-fat-diet, sho …
Molecular control of systemic bile acid homeostasis by the liver glucocorticoid receptor.
Rose AJ, Berriel Díaz M, Reimann A, Klement J, Walcher T, Krones-Herzig A, Strobel O, Werner J, Peters A, Kleyman A, Tuckermann JP, Vegiopoulos A, Herzig S. Rose AJ, et al. Among authors: vegiopoulos a. Cell Metab. 2011 Jul 6;14(1):123-30. doi: 10.1016/j.cmet.2011.04.010. Cell Metab. 2011. PMID: 21723510
Systemic bile acid (BA) homeostasis is a critical determinant of dietary fat digestion, enterohepatic function, and postprandial thermogenesis. ...Our results demonstrate a role of the HPA axis in the endocrine regulation of BA homeostasis through the liver GR contr …
Systemic bile acid (BA) homeostasis is a critical determinant of dietary fat digestion, enterohepatic function, and postprandial ther …
Control of adipose tissue inflammation through TRB1.
Ostertag A, Jones A, Rose AJ, Liebert M, Kleinsorg S, Reimann A, Vegiopoulos A, Berriel Diaz M, Strzoda D, Yamamoto M, Satoh T, Akira S, Herzig S. Ostertag A, et al. Among authors: vegiopoulos a. Diabetes. 2010 Aug;59(8):1991-2000. doi: 10.2337/db09-1537. Epub 2010 Jun 3. Diabetes. 2010. PMID: 20522600 Free PMC article.
The pseudokinase tribbles (TRB) 3 has been identified by us and others as a critical regulator of hepatic glucose homeostasis in type 2 diabetes and WAT lipid homeostasis. ...CONCLUSIONS: As inflammation is typically seen in sepsis, insulin resistance, and obesity-related …
The pseudokinase tribbles (TRB) 3 has been identified by us and others as a critical regulator of hepatic glucose homeostasis in type …
Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes.
Vegiopoulos A, Müller-Decker K, Strzoda D, Schmitt I, Chichelnitskiy E, Ostertag A, Berriel Diaz M, Rozman J, Hrabe de Angelis M, Nüsing RM, Meyer CW, Wahli W, Klingenspor M, Herzig S. Vegiopoulos A, et al. Science. 2010 May 28;328(5982):1158-61. doi: 10.1126/science.1186034. Epub 2010 May 6. Science. 2010. PMID: 20448152
Studying mouse models, we show that cyclooxygenase (COX)-2, a rate-limiting enzyme in prostaglandin (PG) synthesis, is a downstream effector of beta-adrenergic signaling in WAT and is required for the induction of BAT in WAT depots. PG shifted the differentiation of …
Studying mouse models, we show that cyclooxygenase (COX)-2, a rate-limiting enzyme in prostaglandin (PG) synthesis, is a downs …
In vivo phosphoenolpyruvate carboxykinase promoter mapping identifies disrupted hormonal synergism as a target of inflammation during sepsis in mice.
Chichelnitskiy E, Vegiopoulos A, Berriel Diaz M, Ziegler A, Kleiman A, Rauch A, Tuckermann J, Herzig S. Chichelnitskiy E, et al. Among authors: vegiopoulos a. Hepatology. 2009 Dec;50(6):1963-71. doi: 10.1002/hep.23194. Hepatology. 2009. PMID: 19821526
Although the liver plays a crucial role in the control of systemic glucose homeostasis, the molecular mechanisms of aberrant hepatic glucose regulation under metabolic stress conditions remain largely unknown. Here we report the development of a liver-specific adeno …
Although the liver plays a crucial role in the control of systemic glucose homeostasis, the molecular mechanisms of aberrant hepatic …
The glucocorticoid receptor controls hepatic dyslipidemia through Hes1.
Lemke U, Krones-Herzig A, Berriel Diaz M, Narvekar P, Ziegler A, Vegiopoulos A, Cato AC, Bohl S, Klingmüller U, Screaton RA, Müller-Decker K, Kersten S, Herzig S. Lemke U, et al. Among authors: vegiopoulos a. Cell Metab. 2008 Sep;8(3):212-23. doi: 10.1016/j.cmet.2008.08.001. Cell Metab. 2008. PMID: 18762022
Aberrant accumulation of lipids in the liver ("fatty liver" or hepatic steatosis) represents a hallmark of the metabolic syndrome and is tightly associated with obesity, type II diabetes, starvation, or glucocorticoid (GC) therapy. ...
Aberrant accumulation of lipids in the liver ("fatty liver" or hepatic steatosis) represents a hallmark of the metabolic syndrome and …
Glucocorticoids, metabolism and metabolic diseases.
Vegiopoulos A, Herzig S. Vegiopoulos A, et al. Mol Cell Endocrinol. 2007 Sep 15;275(1-2):43-61. doi: 10.1016/j.mce.2007.05.015. Epub 2007 Jun 2. Mol Cell Endocrinol. 2007. PMID: 17624658 Review.
Whereas physiological levels of GCs are required for proper metabolic control, excessive GC action has been tied to a variety of pandemic metabolic diseases, such as type II diabetes and obesity. Highlighted by its importance for human health, the investigation of molecula …
Whereas physiological levels of GCs are required for proper metabolic control, excessive GC action has been tied to a variety of pand …
Nuclear receptor cofactor receptor interacting protein 140 controls hepatic triglyceride metabolism during wasting in mice.
Berriel Diaz M, Krones-Herzig A, Metzger D, Ziegler A, Vegiopoulos A, Klingenspor M, Müller-Decker K, Herzig S. Berriel Diaz M, et al. Among authors: vegiopoulos a. Hepatology. 2008 Sep;48(3):782-91. doi: 10.1002/hep.22383. Hepatology. 2008. PMID: 18712775
CONCLUSION: By preventing the mobilization of hepatic TG stores, the induction of RIP140 in liver provides a molecular rationale for hepatic steatosis in starvation, sepsis, or cancer cachexia. ...
CONCLUSION: By preventing the mobilization of hepatic TG stores, the induction of RIP140 in liver provides a molecular rationale for …
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