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Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk.
Chow LM, Fournel M, Davidson D, Veillette A. Chow LM, et al. Nature. 1993 Sep 9;365(6442):156-60. doi: 10.1038/365156a0. Nature. 1993. PMID: 8371758
The activity of these two enzymes is repressed by phosphorylation of a conserved carboxy-terminal tyrosine residue. Recent studies suggest that this inhibitory phosphorylation may be caused by p50csk (for C-terminal Src kinase), a tyrosine protein kinase which accum …
The activity of these two enzymes is repressed by phosphorylation of a conserved carboxy-terminal tyrosine residue. Recent studies su …
Association of tyrosine kinase p56lck with CD4 inhibits the induction of growth through the alpha beta T-cell receptor.
Haughn L, Gratton S, Caron L, Sékaly RP, Veillette A, Julius M. Haughn L, et al. Nature. 1992 Jul 23;358(6384):328-31. doi: 10.1038/358328a0. Nature. 1992. PMID: 1322497
Rather, the results demonstrate that the CD4-p56lck complex provides prerequisite signals for antigen-receptor-induced T-cell growth and thus characterize a molecular mechanism for functional constraints imposed on T-cell activation by the MHC....
Rather, the results demonstrate that the CD4-p56lck complex provides prerequisite signals for antigen-receptor-induced T-cell growth and thu …
Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn.
Davidson D, Chow LM, Fournel M, Veillette A. Davidson D, et al. J Exp Med. 1992 Jun 1;175(6):1483-92. doi: 10.1084/jem.175.6.1483. J Exp Med. 1992. PMID: 1375262 Free PMC article.
As a result of alternative splicing, p59fyn exists as two isoforms that differ exclusively within a short sequence spanning the end of the Src Homology 2 (SH2) region and the beginning of the tyrosine protein kinase domain. ...To further understand the role of p59fy …
As a result of alternative splicing, p59fyn exists as two isoforms that differ exclusively within a short sequence spanning th …
Structural requirements for enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.
Caron L, Abraham N, Pawson T, Veillette A. Caron L, et al. Mol Cell Biol. 1992 Jun;12(6):2720-9. doi: 10.1128/mcb.12.6.2720. Mol Cell Biol. 1992. PMID: 1375326 Free PMC article.
Such a finding is consistent with the previous demonstration that this site is required for full activation of p56lck by mutation of tyrosine 505. ...Our results indicate that p56lck regulates T-cell antigen receptor signalling through a complex process requiring mu …
Such a finding is consistent with the previous demonstration that this site is required for full activation of p56lck by mutation of …
tkl is the avian homolog of the mammalian lck tyrosine protein kinase gene.
Chow LM, Ratcliffe MJ, Veillette A. Chow LM, et al. Mol Cell Biol. 1992 Mar;12(3):1226-33. doi: 10.1128/mcb.12.3.1226. Mol Cell Biol. 1992. PMID: 1545804 Free PMC article.
We have tested the possibility that tkl, a partially characterized avian tyrosine protein kinase gene, is the chicken homolog of lck, a lymphocyte-specific mammalian gene. ...A specific RNase protection assay revealed that, in contrast to a previous re …
We have tested the possibility that tkl, a partially characterized avian tyrosine protein kinase gene, is the chicken homolog of lck, …
Src-related protein tyrosine kinases and T-cell receptor signalling.
Veillette A, Davidson D. Veillette A, et al. Trends Genet. 1992 Feb;8(2):61-6. doi: 10.1016/0168-9525(92)90351-4. Trends Genet. 1992. PMID: 1566373 Review.
Regulation of the enzymatic function of the lymphocyte-specific tyrosine protein kinase p56lck by the non-catalytic SH2 and SH3 domains.
Veillette A, Caron L, Fournel M, Pawson T. Veillette A, et al. Oncogene. 1992 May;7(5):971-80. Oncogene. 1992. PMID: 1570157
Indeed, substitution of this tyrosine residue by a non-phosphorylatable phenylalanine results in a constitutively activated version of p56lck that can transform rodent fibroblasts. ...Moreover, they indicate that the SH2 domain also plays a positive role in t …
Indeed, substitution of this tyrosine residue by a non-phosphorylatable phenylalanine results in a constitutively activated ve …
Profound block in thymocyte development in mice lacking p56lck.
Molina TJ, Kishihara K, Siderovski DP, van Ewijk W, Narendran A, Timms E, Wakeham A, Paige CJ, Hartmann KU, Veillette A, et al. Molina TJ, et al. Nature. 1992 May 14;357(6374):161-4. doi: 10.1038/357161a0. Nature. 1992. PMID: 1579166
The protein Lck (p56lck) has a relative molecular mass of 56,000 and belongs to the Src family of tyrosine kinases. It is expressed exclusively in lymphoid cells, predominantly in thymocytes and peripheral T cells. ...Lck-deficient mice show a pronounced thymic atro …
The protein Lck (p56lck) has a relative molecular mass of 56,000 and belongs to the Src family of tyrosine kinases. It is expressed e …
Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation.
Abraham N, Veillette A. Abraham N, et al. Mol Cell Biol. 1990 Oct;10(10):5197-206. doi: 10.1128/mcb.10.10.5197. Mol Cell Biol. 1990. PMID: 1697929 Free PMC article.
Mutation of the major site of in vivo tyrosine phosphorylation of p56lck (tyrosine 505) to a phenylalanine constitutively enhances the p56lck-associated tyrosine-specific protein kinase activity. ...The results indicated that activation of p56lck by mutation of Tyr-505 was …
Mutation of the major site of in vivo tyrosine phosphorylation of p56lck (tyrosine 505) to a phenylalanine constitutively enhances th …
Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.
Abraham N, Miceli MC, Parnes JR, Veillette A. Abraham N, et al. Nature. 1991 Mar 7;350(6313):62-6. doi: 10.1038/350062a0. Nature. 1991. PMID: 1706070
Genetic analyses suggest that the interaction of CD4/CD8 with p56lck results in a positive signal during antigen-induced T-cell activation. To evaluate directly the role of p56lck in T-cell activation, we introduced a constitutively activated form of Lck protein (ty …
Genetic analyses suggest that the interaction of CD4/CD8 with p56lck results in a positive signal during antigen-induced T-cell activ …
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