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Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV.
Balzarini J, Camarasa MJ, Pérez-Pérez MJ, San-Félix A, Velázquez S, Perno CF, De Clercq E, Anderson JN, Karlsson A. Balzarini J, et al. Among authors: velazquez s. J Virol. 2001 Jul;75(13):5772-7. doi: 10.1128/JVI.75.13.5772-5777.2001. J Virol. 2001. PMID: 11390579 Free PMC article.
[2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 1.
Balzarini J, Pérez-Pérez MJ, San-Félix A, Velazquez S, Camarasa MJ, De Clercq E. Balzarini J, et al. Among authors: velazquez s. Antimicrob Agents Chemother. 1992 May;36(5):1073-80. doi: 10.1128/AAC.36.5.1073. Antimicrob Agents Chemother. 1992. PMID: 1510396 Free PMC article.
Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit.
Jonckheere H, Taymans JM, Balzarini J, Velázquez S, Camarasa MJ, Desmyter J, De Clercq E, Anné J. Jonckheere H, et al. Among authors: velazquez s. J Biol Chem. 1994 Oct 14;269(41):25255-8. J Biol Chem. 1994. PMID: 7523383 Free article.
Suppression of the breakthrough of human immunodeficiency virus type 1 (HIV-1) in cell culture by thiocarboxanilide derivatives when used individually or in combination with other HIV-1-specific inhibitors (i.e., TSAO derivatives).
Balzarini J, Pérez-Pérez MJ, Vélazquez S, San-Félix A, Camarasa MJ, De Clercq E, Karlsson A. Balzarini J, et al. Among authors: velazquez s. Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5470-4. doi: 10.1073/pnas.92.12.5470. Proc Natl Acad Sci U S A. 1995. PMID: 7539917 Free PMC article.
Human immunodeficiency virus type 1-specific [2',5'-bis-O-(tert- butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"- oxathiole-2",2"-dioxide)-purine analogues show a resistance spectrum that is different from that of the human immunodeficiency virus type 1-specific non-nucleoside analogues.
Balzarini J, Velazquez S, San-Felix A, Karlsson A, Perez-Perez MJ, Camarasa MJ, De Clercq E. Balzarini J, et al. Among authors: velazquez s. Mol Pharmacol. 1993 Jan;43(1):109-14. Mol Pharmacol. 1993. PMID: 7678689
143 results